36results about How to "Significant retention" patented technology

The present invention provides a flowable composition suitable for use as a controlled release implant. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a cell-cycle dependent biological agent, a schedule-dependent biological agent, a metabolite thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides a method of treating cancer in a mammal. The present invention also provides a method of blocking, impeding, or otherwise interfering with cell cycle progression at the G1-phase, G1 / S interphase, S-phase, G2 / M interface or M-phase of the cell cycle in a mammal. The methods includes administering to a mammal an effective amount of a flowable composition of the present invention.

In an embodiment of the invention, a frictional tissue sampling device with an expandable balloon and associated abrasive material can be used to obtain tissue biopsy samples. A frictional tissue sampling device with expandable abrasive material can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device can be passes through a catheter into a body canal to sample epithelial tissue.

The invention provides methods for treating methylated nucleic acids. In one embodiment, the method can include the steps of (a) providing an alkali environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as to form a treated nucleic acid sample where methylated nucleotides in the nucleic acid sample remain unchanged while unmethylated nucleotides are converted to another form; (c) diluting the treated nucleic acid sample so as to reduce salt concentration to a level which will not substantially interfere with a nucleic acid precipitating step; (d) precipitating the diluted treated nucleic acid to substantially remove any unwanted reagents or diluents from treated nucleic acid; and (e) carrying out de-sulphonation of the precipitated treated nucleic acid so as to remove sulphonate groups present on the treated nucleic acid so as to obtain a nucleic acid sample substantially free of sulphonate groups.

A modular assembly for detachable securing an accessory component to a garment or the like, comprises a meshed fabric, with an array of first openings forming an integral part of the garment. A base plate and a locking plate are provided, the former being secured to the accessory component. A plurality of studs are provided on one of the plates, and a plurality of second openings are provided on the other of the plates. The plates are adapted to be positioned on opposite sides of the meshed fabric, with the studs on the one plate projecting through respective first openings in the meshed fabric and into interlocked engagement within the second openings of the other plate.

Embodiments of the subject invention pertain to a method and apparatus for vibrational energy harvesting via electromagnetic induction using a magnet array. Specific embodiments of the subject invention incorporate at least one conductive coil and at least one magnet array. Magnets used in such magnet arrays can be permanent magnets of various shapes, such as arc-shaped, square, rectangular, wedge, or trapezoidal. These magnet arrays can then be, for example, circular, hexagonal, rectangular, or square in external shape and create various types of internal magnetic fields, such as dipole, quadrupole, hexapole, or octapole magnetic fields. Through use of a magnet array, embodiments of the invention can increase the strength of magnetic fields by approximately 10 times compared to typical vibrational energy harvesters. The 10 time increase in the strength of the magnetic fields can result in up to a 100-fold increase in power. Preferably, the magnetic fields created by the subject device are substantially, if not completely, enclosed within the device.

The invention provides methods for treating methylated nucleic acids. In one embodiment, the method can include the steps of (a) providing an alkali environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as to form a treated nucleic acid sample where methylated nucleotides in the nucleic acid sample remain unchanged while unmethylated nucleotides are converted to another form; (c) diluting the treated nucleic acid sample so as to reduce salt concentration to a level which will not substantially interfere with a nucleic acid precipitating step; (d) precipitating the diluted treated nucleic acid to substantially remove any unwanted reagents or diluents from treated nucleic acid; and (e) carrying out de-sulphonation of the precipitated treated nucleic acid so as to remove sulphonate groups present on the treated nucleic acid so as to obtain a nucleic acid sample substantially free of sulphonate groups.

The invention provides methods for treating nucleic acid, particularly nucleic acid that is methylated. In one embodiment, the method can include the steps of (a) providing a denaturing environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as to form a treated nucleic acid sample where methylated nucleotides in the nucleic acid sample remain unchanged while unmethylated nucleotides are converted to another form; (c) diluting the treated nucleic acid sample so as to reduce salt concentration to a level which will not substantially interfere with a nucleic acid precipitating step; (d) precipitating the diluted treated nucleic acid to substantially remove any unwanted reagents or diluents from treated nucleic acid; and (e) carrying out de-sulphonation of the precipitated treated nucleic acid so as to remove sulphonate groups present on the treated nucleic acid so as to obtain a nucleic acid sample substantially free of sulphonate groups.

An improved medical device tube is disclosed for use in a percutaneous procedure. An improved medical procedure is also disclosed to insert a cannulated screw across a fracture of a human bone using the improved tube.

Methods for treating nucleic acid including: (a) providing an alkali environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as to form a treated nucleic acid sample where methylated nucleotides in the nucleic acid sample remain unchanged while unmethylated nucleotides are converted to another form; (c) removing unwanted reagents or diluents from the treated nucleic acid sample; and (d) carrying out de-sulphonation of the precipitated treated nucleic acid at a temperature from 70° C. to 95° C. by adjusting the precipitated treated nucleic acid to a pH of between 10 and less than 12.5 to remove sulphonate groups present on the treated nucleic acid and obtain a nucleic acid sample substantially free of sulphonate groups.

A system for scheduling resources and rules for routing includes a server connected to a network, a scheduling application executable from the server, and at least one programmable software agent for scheduling routing rules. The scheduling application receives statistics about forecast arrival rates for incoming interactions and current resource availability data and schedules resources and routing rules according to the forecast requirements the software agent propagating the portion of scheduling relative to the routing rules.

The invention relates generally to lithographic patterning of very small features. In particular, the invention relates generally to patterning of semiconductor circuit features smaller than lithographically defined using either conventional optical lithography or next generation lithography techniques. The invention relates more particularly, but not by way of limitation, to lateral trimming of photoresist images.

A method for producing a hydrogel / fibre composite comprises: impregnating fibres of a fibrous material with a precursor solution comprising at least one polymerisable, and optionally also crosslinkable, monomer such that at least partial swelling of the fibres takes place; and polymerising, and optionally also crosslinking, the at least one monomer after impregnation and at least partial swelling of the fibres such that the integrity of the fibrous material is at least partially preserved in the resulting hydrogel / fibre composite, provided that the crosslinking is not initiated solely by cation release from the fibres of the fibrous material. The invention provides a hydrogel / fibre composite prepared or preparable by the said method. The hydrogel / fibre composite may be adhesive to human skin with good properties of performance and subsequent painless removal. The composite is found to maintain acceptable strength and structural integrity on hydration or across one or more hydration / dehydration cycle, and thus finds use in, for example, biomedical products where this property is required.

The present invention relates to a process for producing a paper or paperboard product which process comprises the steps of, providing a furnish comprising fibers, adding starch to the furnish, adding microfibrillated cellulose to the furnish, conducting the furnish to a wire in order to form a web, wherein the starch and microfibrillated cellulose is added separately to the furnish.

The invention discloses a method for simultaneously determining sweetening agents and preservatives in tobacco essence, and belongs to the technical field of chemical component detection of auxiliary materials for tobaccos. The method comprises the following steps that 1, a sample to be determined is diluted, the pH value of a solution is regulated to be 9-10, extraction is performed, extraction liquid is purified through an Oasis HLB column, and the purified extraction liquid is filtered for standby application; 2, filtrate is taken to be subjected to ion chromatographic analysis, and the content of the sweetening agents and the preservatives in the sample to be determined is calculated by contrasting a standard curve. According to the method, impurities disturbing determination in the essence are purified and removed in a classifying mode according to the physical and chemical properties of different types of the tobacco essence, one-time sample feeding is performed on the three sweetening agents (sodium cyclamate, acesulfame and saccharin sodium) and the two preservatives (sorbic acid and benzoic acid) through an AS17C analytical column and an electrical conductivity detector, and separation and determination are simultaneously performed. Compared with an industrially recommended determination method, the method has the advantages of being wide in linear range, low in quantitation limit, little in sampling quantity, high in determination efficiency and the like.

Disclosed herein are devices, methods, systems and kits adapted for vitrification and / or reanimation of oocytes, embryos or blastocysts. The device includes a straw and a filter, wherein the straw comprises a lumen traversing through the straw and has a proximal section, a middle section and a distal section and wherein the filter is affixed in the straw and comprises a plurality of pores having a diameter smaller than the diameter of said oocytes, embryos or blastocysts but large enough to allow the passage of a fluid composition therethrough.

A device enables a patient to perform non-invasive punctal occlusion by applying firm pressure to the skin external to the lacrimal canaliculi during the administration of eyedrop medicine, for the purpose of prolonging the medicine retention time. The device of this invention may be adjusted to fit the nasal aspect of the orbital rims where the lacrimal canaliculi are located. The pressure to be applied on the lacrimal canaliculi is adjustable to meet the optimal pressure requirement. The device also has a visual reference attachment that provides visual referencing points for positioning the tip of the eyedrop bottle towards the eyes. This device enables a hands-free operation and does not interfere with the wearing of eyeglasses.

In an embodiment of the invention, a frictional tissue sampling device with an expandable balloon and associated abrasive material can be used to obtain tissue biopsy samples. A frictional tissue sampling device with expandable abrasive material can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device can be passes through a catheter into a body canal to sample epithelial tissue.

The current invention discloses a drug delivery system allowing monitoring of spatial position and drug release, as well as methods and uses thereof. More particularly, the drug delivery system comprises drug carrying particles comprising novel combinations of magnetic resonance imaging contrast agents.

A process for improving the color stability of colored fibers containing keratin, in particular human hair, during the permanent shaping of fibers containing keratin, compositions suitable for this purpose comprising at least one silk protein hydrolyzate derivatized with at least one fatty acid and at least one keratin-reducing compound, and also a process for the permanent shaping of colored fibers containing keratin using the compositions.

A wheelchair (1) is described. The chair comprises a seat (2) and a back (3) that are pivotally supported in two side members (4, 5) and are kinematically interconnected in such manner that an angle between the seat and the back will increase when the back is swivelled backwards about is pivotal support in the side members, which kinematic connection comprises a link connection between the seat and the back. The link connection is in the form of a link arm (12) arranged under the respective pivot supports of the seat and the back so that the distance between the back pivot support (15) and the back link arm connection (13) is less than the distance between the seat pivot support (16) and the seat link arm connection (14), and that the axis of rotation (20) of the seat through the seat's pivot support (16) in the side members passes essentially through or close to the user's centre of gravity (17).

The present invention relates to a polymer composition (C) comprising: —a polyphenylene sulfide (PPS), —at least 3 wt. % of polyamide 6 (PA6), —25 to 60 wt. % of reinforcing agents, —3 to 8 wt. % of a functionalized, non-aromatic elastomer, wherein the weight ratio PPS / PA6 is at least 4 and wherein wt. % are based on the total weight of the composition. The present invention also relates to articles incorporating the polymer composition and the use of polyamide 6 (PA6) as a heat-aging stabilizer in a polymer composition.

A method of transferring functionalized graphene comprising the steps of providing graphene on a first substrate, functionalizing the graphene and forming functionalized graphene on the first substrate, delaminating the functionalized graphene from the first substrate, and applying the functionalized graphene to a second substrate.

The present invention is directed to fibers comprising a copolymer of polyethylene terephthalate and poly(ethylene napthalate) (PETN). These fibers are used in polyester fiberfill batts, structures and articles made therefrom. Such articles provide superior bulk retention on exposure to high temperature.

The present invention relates to a method for extracting phenolic compounds with low molecular weights from olive fruit water; the invention also relates to compositions enriched with phenolic compounds including at least 40% of dry matter, said dry matter consisting of at least 30% hydroxytyrosol; the invention also relates to a method for drying said compositions by spraying using grape polyphenol extracts as a drying medium as well as to powders titrated with phenolic compounds of olives and grapes obtained after drying.