32results about How to "Reduce bioburden" patented technology

An injection member penetrates an elastic septum of a device defining a sealed, empty, sterile chamber in fluid communication with the septum. During penetrating, an annular interface is formed between the septum and the injection member extending axially between a penetration point on an interior surface of the septum in fluid communication with the sterile chamber, and an exterior surface of the septum engaging the injection member. The injection member is de-contaminated by (i) friction between the septum and injection member at the annular interface, and (ii) elongation of the septum at the annular interface. A substance is introduced through the injection member and into the sterile chamber of the device, the injection member is then withdrawn from the septum, the septum reseals itself at the resulting penetration aperture, and the chamber is maintained sterile throughout the foregoing steps.

Cold plasma treatment may be used to sanitize the surface of porous foods. Surprisingly, such treatment may have little or no effect on the oxidative stability of sensitive surface coatings comprising, for example, fats, vitamins, or other compounds subject to degradation by heat, UV treatment, and / or oxidation.

A method for preparing a sterilized human acellular dermal allograft where the dermal allograft is sterilized by irradiation and has a greatly reduced bio-burden and enzymatic and antigenic activity. This product line of allografts can be easily used by surgeons in soft tissue replacement or repair and has an extended shelf life, of up to at least about three years.

Medical devices such as medical containers can be formed of glass and annealed which produces a clean device having a low bio-burden, or formed by plastic molding which produces a clean device. The clean devices are immediately transferred to a controlled environment such as a clean room or localized area to avoid the need to maintain cleanliness levels in an entire room. Syringe tip closures can be introduced into the housing assembly, where syringe barrels and tip closures are cleaned with filtered ionized air and the tip closures are coupled to the barrels. The syringe barrels can be filled with a substance and a closure member attached. While still in the housing assembly the syringe barrels can be formed into an array and placed in a clean outer container, which is then closed and sealed.

Methods for processing tissue are provided. In some embodiments, the methods comprise methods for decellularizing tissue samples by applying high hydrostatic pressure to the tissues samples. In some embodiments, the methods comprise methods for thawing tissue samples and / or reducing the bioburden in a sample by applying high hydrostatic pressure to the tissue samples.

The invention relates to a city watercourse drain outlet sewage treatment method. The method mainly comprise the steps of regulation, wherein sewage is introduced into a regulating reservoir for regulation; mixing with flocculant, wherein sewage in the regulating reservoir is led out to be mixed with flocculant; flocculent settling, wherein sewage mixed with flocculant is sequentially introduced into a baffle flocculation reaction tank and a settling tank for sewage flocculation and sludge precipitation separation; denitrification, wherein water discharged from the settling tank and part of water discharged from a nitration aerating filter are introduced into a denitrification filter for denitrification; aerobiotic nitration, wherein water discharged from the denitrification filter is introduced into a nitration aerating filter for nitration; filtration, wherein part of water discharged from the nitration aerating filter is introduced into a filtering device for filtration. The invention further provides a sewage treatment device adopting the method. The sewage treatment device comprises a regulating reservoir, a pipeline mixer, a baffle flocculation reaction tank, an oblique plate settling tank, a denitrification filter, a nitration aerating filter and a clear water pond which are connected in series, wherein a water outlet pipeline of the clear water pond is connected to a filter device.

The invention provides a diversion based biological film waste water integrated treatment process, which comprises the following steps of S1, building a diversion based biological film waste water treatment system which comprises a grid, a regulating tank, an anaerobic tank, a hydrolysis acidification tank, a secondary aerobic tank, a sedimentation tank, a rapid filter tank, an ozone tank, an ultraviolet disinfecting pipe and a clean water discharge pipe; S2, removing float in the waste water via the grid, performing primary sedimentation, separation and adjustment of water quality and water volume via the regulating tank, performing anaerobic treatment via the anaerobic tank, and carrying out hydrolysis acidification via the hydrolysis acidification tank; S3, performing aerobic treatmentvia the secondary aerobic tank, treating via the sedimentation tank, the rapid filter tank, the ozone tank and the ultraviolet disinfecting pipe, and discharging from the clean water discharge pipe, thereby completing the diversion based biological film waste water integrated treatment process. The treatment process completes the effective treatment of the waste water via the built diversion basedbiological film waste water treatment system., and has the advantages of wide application, operation convenience and high performance to cost.

Included are food packaging materials and processes that are useful for commercial products to extend the freshness and preserve the integrity and shelf-life of packaged foods. Said food packaging materials utilize a low bioburden, biodegradable and / or compostable shock absorbing / cushioning nonwoven structure and some form or forms of an antimicrobial and / or antifungal agent consisting of silver or silver-based species that destroy microbes which would otherwise spoil the food. The shelf-life extension process involves silver-based antimicrobial agents that function to mitigate the spread of food spoilage pathogens when they come in contact with the said food packaging materials. Fluid absorbing or superabsorbent, capabilities may be incorporated in the structure to control excess fluids.

The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.

The present disclosure comprises antimicrobial compositions and devices comprising silver compounds that resist heat and light discoloration. In one aspect, the said compounds comprise silver and at least one s-triazine ring or moiety. In another aspect, the antimicrobial compositions are hydrogels that are effective against broad spectrum of common pathogens including MRSA and VRE and are suitable for treating human or animal wounds and burns. The methods of the present disclosure comprise treating medical and non-medical devices and articles with compositions comprising the silver compounds to impart antimicrobial property.

The present disclosure provides novel bone matrix (BM) materials, and methods for preparation and use of the demineralized bone matrix materials and compositions therefrom. The methods of preparation include the use of a closed-vessel demineralization system, as well as simple, easily reproducible process steps, and significantly shortened times for demineralization. These novel BM materials do not require the inclusion of carriers and / or delivery agents, or the addition of binders, and can be made in various forms, including a clay, putty, crush, powder, or gel. The novel BM compositions and methods disclosed herein may, illustratively, have applications in the medical field, such as in surgical bone graft applications, in the repair and / or regeneration of bone and bone-related tissue, and the like.

The present disclosure provides novel bone matrix (BM) materials, and methods for preparation and use of the demineralized bone matrix materials and compositions therefrom. The methods of preparation include the use of a closed-vessel demineralization system, as well as simple, easily reproducible process steps, and significantly shortened times for demineralization. These novel BM materials do not require the inclusion of carriers and / or delivery agents, or the addition of binders, and can be made in various forms, including a clay, putty, crush, powder, or gel. The novel BM compositions and methods disclosed herein may, illustratively, have applications in the medical field, such as in surgical bone graft applications, in the repair and / or regeneration of bone and bone-related tissue, and the like.

The invention discloses a preparation method of photothermal antibacterial near-infrared bimetallic nanoparticles. The preparation method comprises: adding chloroauric acid, copper chloride, long-chain organic amine and reducing agent into ultrapure water and stirring overnight, and Heating in an oil bath, cooling the reaction product, centrifuging it, dissolving the resulting precipitate in deionized water, washing with deionized water and ethanol three to four times, and drying in vacuum to obtain near-infrared bimetallic nanoparticles . The invention obtains near-infrared bimetallic nanoparticles. Compared with other nanoparticles, it has a certain antibacterial activity, and can also realize photothermal sterilization under near-infrared light irradiation. The combination of the two shows high-efficiency antibacterial activity. , can be widely used in biological materials, medical devices, wound antibacterial disinfection, etc., and reduces the risk of bacterial drug resistance, and has broad application prospects in the field of antibacterial materials in the future.

The present invention belongs to the field of pharmaceutical industry and relates to a solid pharmaceutical composition comprising androgen receptor antagonists, e.g. Enzalutamide or ARN-509, as well as to processes for preparing the same. The solid pharmaceutical compositions are useful in the treatment of prostate cancer.

An inactivation method of the pathogenic microorganisms of chitosan belongs to the technical field of the biological material processing. The method comprises the following steps: performing primary inactivation to the pathogenic microorganisms of chitosan with NaOH solution, then drying chitosan, introducing nitrogen, sealing, and performing 10-50kGy of gamma-ray irradiation at -20 to 30 DEG C to inactivate possible pathogenic microorganisms in chitosan and ensure the safety of chitosan used as the biological material. Compared with the existing inactivation method of the pathogenic microorganisms, by using the method of the invention, the pathogenic microorganisms such as bacteria and viruses can be effectively killed, the quality indexes of chitosan such as deacetylation degree and crystallization degree can not change and the reduction of the molecular weight is obviously lower than that of other inactivation methods. Therefore, the quality and function of the biological material can be maintained while the pathogenic microorganisms brought by the possible pollution can be effectively killed.

The invention relates to an urban sewage SDA+BAF treatment system. The system comprises a fine separation device, an adjusting buffer tank, a facultative tank, an ultrasonic vibration sedimentation tank, an SND reactor, an SAD reactor, a BAF reactor, a clean water tank, an ozone disinfection tank and a metering discharge channel which are connected in sequence, the fine separation device is a finesilk screen filtering mechanism and has a self-cleaning function; an ultrasonic vibration separation plate is arranged in the ultrasonic vibration sedimentation tank, the SND reactor, the SAD reactorand the BAF reactor are respectively of fluidized bed type structures, and a water distribution layer, a water distribution layer and a packing layer are specially designed, and packing with specificproportions and components is arranged in each reactor. The invention also discloses a treatment process for an urban sewage SDA+BAF treatment system. The Urban sewage SDA+BAF treatment system and the treatment process thereof have the beneficial effects that the power consumption is low, the effluent quality stability is high, the physical suspended matter removal and sludge generation amount issmall, an additional carbon source is not needed, and the medicament cost is saved.

The present disclosure provides novel bone matrix (BM) materials, and methods for preparation and use of the demineralized bone matrix materials and compositions therefrom. The methods of preparation include the use of a closed-vessel demineralization system, as well as simple, easily reproducible process steps, and significantly shortened times for demineralization. These novel BM materials do not require the inclusion of carriers and / or delivery agents, or the addition of binders, and can be made in various forms, including a clay, putty, crush, powder, or gel. The novel BM compositions and methods disclosed herein may, illustratively, have applications in the medical field, such as in surgical bone graft applications, in the repair and / or regeneration of bone and bone-related tissue, and the like.

The invention discloses a carbon and nitrogen removal device for waste water with high ammonia nitrogen and high organic matter, which comprises an anaerobic fermentation tank, a high DO decomposition tank, a medium DO nitrification tank, a denitrification filter tank, a sedimentation tank and a disinfection tank connected in sequence; The top of the oxygen fermentation tank communicates with the bottom of the denitrification filter; the bottoms of the anaerobic fermentation tank, high DO decomposition tank, medium DO nitrification tank and sedimentation tank are all equipped with mud discharge ports, and each mud discharge port is connected to the denitrification tank through the mud discharge pipe respectively. The mud storage tank is connected; the mud discharge port of the mud storage tank is connected with the sludge hydrolysis tank, and the sludge hydrolysis tank is connected with the denitrification filter tank. The beneficial effects of the present invention are: the use of anaerobic fermentation to treat the original wastewater not only improves the biodegradability of the wastewater, but also reduces the biological load of subsequent treatment; the process of removing COD and the nitrification process can be separated to avoid the excessive organic load on the nitrification reaction Inhibition; the methane produced by anaerobic fermentation and the hydrolyzate of excess sludge are used as denitrification carbon sources, which not only saves operating costs, but also contributes to energy conservation and emission reduction.