The invention relates to a cigarette nicotine reducing preparation formula, a preparation method of a cigarette nicotine reducing preparation and a blended tobacco shred preparation method. The formula comprises heat clearing and toxicity removing components such as cortex phellodendri, root of chinese barberry, hedyotis diffusa, honeysuckle stem, mesona chinensis, portulaca oleracea, schizonepeta and wikstroemia indica, addable lung moistening and phlegm removing components such as inula flower, cicada slough, momordica grosvenori, flos farfarae, sea clam shell, radix platycod and scaphium scaphigerum, heart-fire clearing and blood cooling components such as lophatherum gracile, salvia miltiorrhiza, jequirity, tabasheer, albizia odoratissima and aegilops tauschii, liver-fire clearing components such as mulberry leaves, polygonum cuspidatum, milk vetch, buddleja officinalis, seed of feather cockscomb and verbena officinalis, as well as stomach moistening and spleen tonifying components such as microcos paniculata, aristolochia kwangsiensis and ophiopogon japonicas, wherein all the components are 1-5 parts. The preparation method of the preparation includes the steps of medicinal material preparation, cleaning, drying, smashing, water addition and grinding, fermenting and the like. The tobacco shred preparation method includes tobacco smashing, water adding and grinding, fermenting, mixing with the preparation, filtering, pressing, drying, shredding, tobacco shred preparing and the like. Tobacco nicotine is lowered, the effect of expelling phlegm to stop cough is achieved, and diseases are prevented.