53results about How to "Low-density lipoprotein" patented technology

The present invention provides a sensor that electrochemically determines cholesterol in low density lipoprotein by only one feed of a sample. The sensor has: an electrode system that is mounted on an electrically insulating base plate and includes at least a working electrode and a counter electrode; an enzyme layer formed on the base plate with the electrode system; and a reagent layer that is arranged before the enzyme layer in a sample solution supply path to the electrode system. The enzyme layer includes at least an oxidoreductase and an electron mediator. The reagent layer includes a reagent that depresses reactivity of cholesterol in lipoproteins other than the low density lipoprotein with the oxidoreductase, for example, a reagent that attaches to lipoproteins other than the low density lipoprotein to form a water-soluble complex.

The invention discloses a compound shown as a formula I or pharmaceutically acceptable salt thereof. In the formula I, R1, R2, R3, R4, R5 and n are defined as the specification. The invention also discloses a preparation method for the compound of the formula I, a composition containing the compound and application of the compound. The compound of the formula I is stable in vitro, has good dissolubility in a pharmaceutically applied organic solvent, and has good bioavailability in the body of an animal. Meanwhile, the invention discloses the preparation method for the compound of the formula I and the application of the compound of the formula I in preparation of medicaments for regulating blood fat and preventing and treating biliary calculus.

The invention provides a light fasting full nutrition formula brewing instant bar and a preparation method thereof. The formula can brew various components of instant nutrient nutrients according to the suggested configuration of the 'Chinese Dietary Guidelines', foods are diverse, and no preservatives, no sweeteners and no artificial pigments are added; the bar is prepared from, by weight, oil, aquatic eggs, dairy products, soybeans, nuts, cereal potatoes, dietary fibers, fruits and vegetables, nutritional strengthening components and the like, is convenient to eat, and is especially suitablefor meeting the full nutritional needs of a body during light fasting and fat reduction.

The invention relates to a pravastatin transdermal administration preparation and a preparation method thereof. In the invention, pravastatin or a pharmaceutically acceptable salt of the pravastatin serves as a medicament active ingredient, and the medicament active ingredient is a filling closed transdermal preparation which consists of a protective layer, an adhesive layer, a controlled-release membrane layer, a medicament reservoir and a backing layer; the medicament reservoir comprises 1 to 20 percent of pravastatin, and the balance of reservoir substrate; the adhesive layer comprises 0 to 10 percent of pravastatin, and the balance of pressure-sensitive adhesive; the reservoir substrate comprises 5 to 50 percent of transdermal enhancer, while the adhesive layer comprises 0 to 20 percent of transdermal enhancer; and the medicament release area of the preparation is 1 to 100 cm<2>. The pravastatin transdermal administration preparation is convenient to use and carry; the first pass effect of a liver and a gastrointestinal tract is avoided; and an in-vivo experiment of an animal proves that the preparation has no irritation or sensitization to skin. The pravastatin transdermal administration preparation can keep stable and persistent blood concentration, the continuous medicament releasing time is 1 to 7 days, so that the preparation provides the more convenient and safer treatment method for a patient.

The invention provides a carboxylic acid derivative compound. The compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof provided by the invention not only can reduce the level of triglyceride in high fat model animal blood, but also has the good function of reducing cholesterol and low-density lipoprotein and the effects of promoting biliation, reducing content of cholesterol in bile and increasing the content of bile acid, and also has the effect of preventing and treating gallstone when being applied to a golden gopher gallstone model. The particular importance is that the compound or the pharmaceutically acceptable salt thereof provided by the invention is low in toxicity.

Compounds represented by the general formula [I]: wherein R1 and R2 are each hydrogen, halogen, an optionally substituted linear hydrocarbon group, or hydroxyl which may be substituted with an optionally substituted liner hydrocarbon group, or R1 and R2 together with the carbon atoms adjacent thereto may form an optionally substituted cyclic hydrocarbon or a dihydrofuran ring which may have an oxo group; ring A is a benzene ring which may be further substituted; ring B is an aromatic ring which may be substituted; X is a bond or a spacer whose main chain has 1 to 6 atoms; Y is carboxyl which may be esterified, carbamoyl which may be substituted, cyano, or an optionally substituted heterocyclic group bearing a hydrogen atom capable of being deprotonated, or salts thereof, which are useful as lipid-rich plaque regressing agents and / or ACAT inhibitors.

A multifunctional external blood therapeutic apparatus is composed of anticoagulating pump, full-blood air filter, centrifugal separator, plasma storage box, blood fat filter, air probe, control valves, blood taking and blood transfusion needles, connection tubes, DPM1, DPM2, waste liquid bag, etc.

The invention discloses a composition with the function of aiding to reduce blood fat, and a preparation method of the composition. The composition comprises the components in parts by weight: 1-12 parts of rhizoma curcumae longae, 1-9 parts of red yeast rice, 1-7 parts of longstamen onion bulb, 3-8 parts of lotus leaves, 2-7 parts of hawthorns, 2-10 parts of rhizoma alismatis, 1-12 parts of semen cassiae and 3-7 parts of polygonum multiflorum. The composition with the function of aiding to reduce blood fat has obvious pharmacologic action for the cardiovascular system, and is capable of well reducing cholesterol and comprehensively adjusting blood lipid metabolism.

The present invention pertains to a silkworm-type biotinylated CTLD14 or sRAGE and a method for manufacturing the same. One embodiment of the present invention provides a method for manufacturing biotinylated proteins, wherein the method includes A) a step for inserting a nucleic acid molecule for coding biotin ligase and protein in a coexpressable manner into a silkworm or a living organism that imparts sugar chains that are the same as the sugar chains of the silkworm, B) a step for causing the biotin ligase and protein to be expressed by disposing the silkworm or the living organism that imparts sugar chains that are the same as the sugar chains of the silkworm to conditions with which the nucleic acid molecule will carry out expression, and C) a step for administering biotin to the living organism and obtaining the biotinylated protein.

A composite medicine for regulating blood fat and treating hyperlipemia is prepared from simavastatin, pantethine, flavone, and pharmacologically acceptable additives. It can also be used to prepare the medicine for decreasing the content of cholesterol in blood.

The invention relates to a traditional Chinese medicinal composition for treating hyperlipidaemia. The traditional Chinese medicinal composition is an ointment which is made from goldthread, grifola umbellate, safflowers, the root of bidentate achyranthes, rhizoma alismatis, the root bark of the peony tree, winged euonymus twigs, poria cocos, cassia twigs, the root of red-rooted salvia, Chinese yams, the root of kudzu vine, dried tangerine or orange peels, fructus amomi, raw coix seeds, fructus aurantii, fructus psoraleae, lotus leaves, agastache rugosus, eupatorium fortune, corn stigmas, wax gourd peels, cattail pollen, fried hawthorn fruits and turtle shell gelatin according to a certain ratio. The traditional Chinese medicinal composition has the advantages that the medicinal composition has a multichannel multi-target-point lipid lowering effect and is used for adjusting blood lipid metabolism, reducing triglyceride and low-density lipoprotein and improving human immunity; the medicinal composition has long-lasting effect and small toxic and side effect, and a preparation method of the medicinal composition is controllable, so that the medicinal composition is suitable for industrial mass production.

A hypolipemic copmosition contains acrivatatine, pantethine and flavone, and can be used to prepare the medicines for decreasing the cholesterol in blood or improving the lipid in blood, so it can be used for treating hyperlipemia.

The invention relates to a traditional Chinese medicine composition for preventing and treating a heart-blood-stasis type coronary heart disease. The traditional Chinese medicine composition is prepared from the following bulk drugs: peach seed, safflower, red sage root, cassia twig, raw licorice root, santal and raw rehmannia root. The invention further provides application of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the advantage that all the traditional Chinese medicines of the composition follow the principles of monarch, minister, assistant and guide, complement each other and realize synthetic action, so the traditional Chinese medicine composition can effectively prevent and treat the heart-blood-stasis type coronary heart disease. Clinical testing results prove that the traditional Chinese medicine composition can substantially reduce the integration of TCM syndromes, lower total cholesterol and low-density lipoprotein, etc.

The invention discloses a use of a statin compound in the preparation of local drugs for improving lipid metabolism and treating obesity, hypertension, hyperlipidemia, fatty liver and hyperglycemia; and statin compound local compositions for improving lipid metabolism and treating obesity, hypertension, fatty liver, hyperlipidemia, atherosclerosis, coronary heart disease, apoplexy and other cardiovascular and cerebrovascular diseases, and drug formulation and preparation method thereof.

Provided is a method of preparing an orange peel ferment, an orange peel ferment obtained therefrom, and a method for reducing fat accumulation, sleep disturbance, and cancer risk. The orange peel ferment assists obese individuals to slim down via multiple mechanisms including reducing the fat content of adipocytes, promoting lysis of triglycerides in adipocytes, and enhancing the expression of genes involved in fat metabolism, and also reduces sleep disturbance through normalizing circadian rhythm and lowers cancer risk through suppressing expression of cancer risk genes.

The invention relates to an ablation and embolism extinguishing preparation of Chinese medicine which is designed aiming at the technical problems existing in the prior art that a plurality of medicaments have long taking time, large dosage, are slow in taking effect and do not have ideal clinical efficacy. The components of the preparation is as follows according to weight percentage: 10 to 30g of rhizoma gastrodiae, 50 to 70g of radix salviae miltiorrhizae, 60 to 80g of astragalus root, 20 to 40g of red peony root, 10 to 30g of dlbergia wood, 30 to 50g of turmeric, 20 to 30g of agkistrodon halys, 20 to 30g of earthworm and 30 to 50g of szechwan lovage rhizome. The preparation method comprises the steps of: putting the pure Chinese medicines of rhizoma gastrodiae, salviae miltiorrhizae, astragalus root, red peony root, dlbergia wood, turmeric and szechwan lovage rhizome in a container after classifying and purifying; drying the agkistrodon halys and earthworm by mild fire, and then preparing into grains and packing into capsule after being ground into powder, screened on 100 mesh sieve and being fully mixed and stirred with all the purified Chinese medicine; and irradiating conventionally by medical Co for later use. The preparation has the characteristics and beneficial effects that: after years of clinical observation, the preparation has reliable embolism resisting and ablation effects, effectively reduces the blood plasma and the whole blood contrast viscosity and reduces the cohesiveness of blood platelet, effectively recovers sequela caused by cardiovascular and cerebrovascular diseases, and especially has the double effects of stroke rehabilitation and preventing from second attack.

The invention relates to a health-care food containing black fungus polysaccharide and a preparation method thereof, and belongs to the technical field of health-care products. In order to solve the problem that black fungus lacks deeply-processed products, the invention provides the health-care food containing black fungus polysaccharide, which comprises the following components in parts by weight: 20-100 parts of black fungus polysaccharide, 10-30 parts of ganoderma lucidum polysaccharide, 10-30 parts of astragalus polysaccharide, 10-20 parts of mulberry freeze-dried powder and 10-20 parts of cranberry freeze-dried powder. The black fungus is deeply processed, and the extracted black fungus polysaccharide has the effect of reducing blood fat and can reduce cholesterol and low-density lipoprotein. The ganoderma lucidum polysaccharide and the astragalus polysaccharide can improve the immunity of a body; and the mulberry freeze-dried powder and the cranberry freeze-dried powder have the effects of supplementing vitamins and trace elements. The raw materials are homologous in medicine and food, safe to take, free of side effects and suitable for long-term taking. The preparation method is simple, high in efficiency and suitable for popularization.

Administration of a therapeutically effective amount of 3,5-diiodothyropropionic acid stimulates weight loss in patients, lowers triglyceride levels and reduces risk of death or progression of coronary heart disease in patients with metabolic syndrome.

The present invention relates to Chinese medicine or health food composition, and Chinese medicine or health food composition for preventing and treating hyperlipemia, hypertension and fatty liver and its application. The composition has material comprising red yeast 5-60 wt%, soybean isoflavone 0.3-50 wt% and oriental water plantain 10-75 wt% as well as haw and / or cassia seed. The composition of the present invention has no toxic side effect, and excellent fat regulating effect to reduce the content of cholesterol, triglyceride and low density lipoprotein in blood obviously. The composition is used in medicine and health food for preventing and treating hyperlipemia, hypertension and fatty liver.

The present specification discloses compositions comprising a pharmaceutical composition to reduce or maintain LDL and / or cholesterol levels in an individual and a plurality of therapeutic compounds to increase or maintain HDL levels in an individual. The present specification also discloses a treatment protocol wherein a pharmaceutical composition is administered to an individual on a schedule wherein the pharmaceutical composition is provided for a period of time and then not provided to the individual and this treatment protocol is repeated for the term of the individual's treatment.

The invention relates to an oral liquid formula capable of regulating blood fat, a preparation method and application thereof. The oral liquid capable of regulating blood fat is prepared from the following components in parts by weight: 2 to 3 parts of inonotuso bliquus (Fr) Pilat, 1.2 to 2.8 parts of fructus crataegi and 16 to 58 parts of water. The preparation method comprises the following steps: weighing the dried raw materials in proportion, crushing, uniformly mixing, extracting with water for 2-6 hours, concentrating, adding 95% ethanol with the volume 3 times that of the dried raw materials for precipitation, standing at 0 DEG C overnight, filtering, drying the precipitate in a drying oven to obtain an inonotuso bliquus polysaccharide extract, adding distilled water for redissolving, and preparing the oral liquid with the volume of 20-30mL per day. The oral liquid capable of regulating the blood fat, provided by the invention, is convenient to take, can reduce total cholesterol, triglyceride and low-density lipoprotein, can increase high-density lipoprotein and regulate the blood fat, so that the oral liquid can be widely applied to the field of health-care foods.

The invention specifically relates to a ginkgo leaf feed and a preparation method thereof, and belongs to the technical field of food processing. The ginkgo leaf feed provided by the invention comprises the following components in percentage by mass: 44%-49% of corn, 34%-40% of soybean meal, 7.5%-15% of ginkgo leaves, 0%-5% of peanut vines, 5% of a premix and 1% of molasses. The feed is prepared through mixing the above components in percentage by mass. According to the feed disclosed by the invention, the ginkgo leaves are added to the feed, so that cholesterol and blood fat of sheep / goats are effectively reduced, fat in mutton is reduced, and the tenderness of the mutton is promoted.

The invention relates to a traditional Chinese medicinal composition for treating hyperlipidaemia. The traditional Chinese medicinal composition is an ointment which is made from goldthread, grifola umbellate, safflowers, the root of bidentate achyranthes, rhizoma alismatis, the root bark of the peony tree, winged euonymus twigs, poria cocos, cassia twigs, the root of red-rooted salvia, Chinese yams, the root of kudzu vine, dried tangerine or orange peels, fructus amomi, raw coix seeds, fructus aurantii, fructus psoraleae, lotus leaves, agastache rugosus, eupatorium fortune, corn stigmas, wax gourd peels, cattail pollen, fried hawthorn fruits and turtle shell gelatin according to a certain ratio. The traditional Chinese medicinal composition has the advantages that the medicinal composition has a multichannel multi-target-point lipid lowering effect and is used for adjusting blood lipid metabolism, reducing triglyceride and low-density lipoprotein and improving human immunity; the medicinal composition has long-lasting effect and small toxic and side effect, and a preparation method of the medicinal composition is controllable, so that the medicinal composition is suitable for industrial mass production.

The invention relates to a liquid oral solution for improving health of capillaries. The liquid oral solution is prepared from a wax gourd extract, a pomegranate extract, astragalus membranaceus, taurine, oligosaccharide, vitamin B, lygodium japonicum leaves, zinc lactate and asparaginic acid. The liquid oral solution has the effects of quickly washing human cells and blood vessel contamination, enhancing the activity of body cells, improving the immunity, and preventing and treating hypertension, heart disease, cerebral thrombosis, diabetes, liver ascites, hydrocephalus, hydrothorax, obesity, angiosclerosis, limb weakness, chronic hepatitis, nephritis, heatstroke and the like, is widely applied to four-season health maintenance and life prolonging drinking of 25 years old or above, and is scientific and reasonable in formula, simple to match and convenient to drink.