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Blood fat reducing composition containing avatatin and its use

A technology of atorvastatin and blood lipid-lowering drugs, which is applied in the field of lipid-improving agent compositions in blood, and can solve the problems that there are no similar composition drugs on the market.

Inactive Publication Date: 2005-08-10
HANGZHOU XINFU TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no similar composition drug on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 tablet

[0020] (1) Ingredients

[0021] Soy Isoflavones Total Ginkgo Flavonoids

[0022] 4 tablets (1400mg) 4 tablets 1400mg)

[0023] Atorvastatin 20mg 20mg

[0024] Pantethine 500mg 500mg

[0025] Soy Isoflavones 225mg -

[0026] Ginkgo Flavonoids - 225mg

[0027] Crystalline Cellulose 120mg 120mg

[0028] Magnesium aluminum metasilicate - -

[0029] Sucrose fatty acid ester 140mg 140mg

[0030] Hydroxypropyl Cellulose 48mg 48mg

[0031] Magnesium Stearate 24mg 24mg

[0032] Crospovidone 48mg 48mg

[0033] Lactose appropriate amount

[0034] (2) Method

[0035] According to the amount of the above-mentioned components, the above-mentioned components are measured, and the granules are prepared according to the item "Granules" of the General Provisions of the Chinese Pharmacopoeia.

Embodiment 2

[0036] Embodiment 2 Granules

[0037] (1) Ingredients

[0038] Soy Isoflavones Total Ginkgo Flavonoids

[0039] 4 packs (5g) 4 packs (5g)

[0040] Atorvastatin 20mg 20mg

[0041] Pantethine 1000mg 1000mg

[0042] Soy Isoflavones 300mg -

[0043] Ginkgo biloba total flavonoids - 300mg

[0044] Refined sucrose 1600mg 1600mg

[0045] Starch 1200mg 1200mg

[0046] Polysorbate 80 48mg 48mg

[0047] Magnesium aluminum metasilicate - -

[0048] Magnesium Stearate 24mg 24mg

[0049] Lactose appropriate amount

[0050] (2) Preparation method: Measure the above-mentioned ingredients according to the amount of each of the above-mentioned ingredients, and prepare granules according to the item "Granules" in the general provisions of the Chinese Pharmacopoeia.

Embodiment 3

[0051] Embodiment 3 capsules

[0052] (1) Ingredients

[0053] Soy Isoflavones Total Ginkgo Flavonoids

[0054] 4 capsules in 4 capsules

[0055]Atorvastatin 20mg 20mg

[0056] Pantethine 500mg 500mg

[0057] Soy Isoflavones 300 -

[0058] Total Ginkgo Flavonoids - 300

[0059] Starch 960mg 960mg

[0060] Polysorbate 80 48mg 48mg

[0061] Magnesium aluminum metasilicate - -

[0062] Magnesium Stearate 24mg 24mg

[0063] Lactose appropriate amount

[0064] (2) Preparation method: Measure the above-mentioned ingredients according to the amounts of the above-mentioned ingredients, and prepare granules according to the item "Capsules" in the general provisions of the Chinese Pharmacopoeia.

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Abstract

A hypolipemic copmosition contains acrivatatine, pantethine and flavone, and can be used to prepare the medicines for decreasing the cholesterol in blood or improving the lipid in blood, so it can be used for treating hyperlipemia.

Description

technical field [0001] The invention relates to a blood lipid improving agent composition, in particular to a composition containing atorvastatin, pantethine and flavonoids, which is used in the preparation of blood lipid-regulating medicines such as improving blood cholesterol content. Background technique [0002] Hyperlipidemia characterized by elevated low-density lipoprotein and very low-density lipoprotein can cause atherosclerotic endothelial cell dysfunction, hyperplatelet aggregation, foam cell formation, etc., and is a major risk factor for premature coronary heart disease in humans One, so the blood lipid improving agent has a broad market prospect. [0003] Atorvastatin is a fully synthetic novel hydroxymethylglutaryl-CoA reductase inhibitor. It is one of the most effective lipid-lowering drugs at present. Its half-life in vivo (t 1 / 2 ) time is longer, the original drug is about 4 hours, and the active metabolite has an inhibitory effect on reductase t 1 / 2 As...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61P3/06
Inventor 过鑫富楼宜嘉
Owner HANGZHOU XINFU TECH CO LTD
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