The invention discloses a dealcoholic sobering-up pharmaceutical preparation and a preparing method thereof; the pharmaceutical preparation is prepared by poria, hawthorn, pueraria, ganoderma lucidum,and hoveniae semoveniae semen. Compared with the prior art, the pharmaceutical preparation has very significant dealcoholic sobering-up effect, protects gastric mucosa, does not hurt the gaster, adjusts gastric motility in two ways, inhibits vomiting, nausea and abdominal distention, directly decomposes alcohol and improves capacity for liquor, resists hypnosis and alleviates headache and head halo, speeds up the emptying time of alcohol in the intestine and gaster, reduces the metabolism burden of the liver and kidney, accelerates the alcohol metabolism in the blood, protects the liver, enhances the immunity and relieves the fatigue. The pharmaceutical preparation is prepared by pure natural plants, and has less medicinal odor, easy quality control, and excellent effects for protecting liver, nourishing gaster and strengthening spleen.