The invention relates to a compound sweetener with mogroside as the primary component, and a preparation method and a use thereof. The invention provides a compound and natural compound sweetener, which can be transformed by mogroside, a traditional sweetener and an edible spice, in betel nut industry, extrusion pastry (commonly known as spicy gluten) industry and fruit and preserved fruit industry, and a preparation method thereof. The compound sweetener including mogroside at least includes mogroside, a natural high-efficiency sweetener, at least one sweet-improving composition, at least onespice and at least one filler. The formula aims at the areca industry, the extrusion pastry (commonly known as spicy gluten) industry and the preserved fruit industry, and the products of the industries need the sweetness several times much higher than saccharose sweetness to mask, neutralize and improve the peculiar smell, astringency, saltiness and bitterness of the products, so conventional common condiments difficultly meet the standards of ensuring the taste, flavor, and no heat and even zero heat. At the same time, the compound sweetener not only ensures the demand of sweetness and efficacy, but also has good economy and effectiveness, and obtains the best taste experience.