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Enrofloxacin effervescent dispersible tablets special for animals and preparation method of same

A technology of enrofloxacin and enrofloxacin hydrochloride, which is applied in the field of enrofloxacin effervescent dispersible tablets for livestock and poultry and its preparation, can solve the problems that farmers are not easy to accept and dissolve for a long time, and achieve drug onset Speed, carrying and transportation, astringency improvement effect

Inactive Publication Date: 2012-10-03
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that the dissolving time of enrofloxacin tablets is too long in the clinical use of livestock and poultry and it is difficult for farmers to accept it, the purpose of the present invention is to provide a special tablet for livestock and poultry that is easy to dissolve in water, convenient to transport, and has excellent palatability. New Enrofloxacin Effervescent Dispersible Tablets and Its Preparation Method

Method used

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  • Enrofloxacin effervescent dispersible tablets special for animals and preparation method of same

Examples

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Effect test

Embodiment 1

[0018] Example 1: First, add 1g of povidone to 10ml of absolute ethanol, fully stir it until it is completely dissolved, and then use it. Take 5g of enrofloxacin hydrochloride raw material, 10g of sodium bicarbonate, 5g of citric acid, 78.98g of soluble starch, 0.02g aspartame was passed through a 40-mesh sieve and mixed uniformly, then wetted with 10ml of 10% povidone ethanol solution to granulate, and the ethanol was volatilized by cold wind to make 100g granules, then sizing and pressing into 50 tablets , The tablet weighs 2g. Usage and dosage: poultry, drinking water, add 50 tablets per 100L, stir to dissolve, use for 3~5d.

Embodiment 2

[0019] Example 2: First, add 2g of povidone into 20ml of absolute ethanol, fully stir it until it is completely dissolved, and then use it. Take 10g of enrofloxacin hydrochloride raw material, 15g sodium bicarbonate, 15g citric acid, 109.95g soluble starch, 0.05g aspartame was passed through a 50-mesh sieve and mixed evenly, and then granulated with 20ml 10% povidone anhydrous ethanol solution. The ethanol was volatilized by cold wind to make 150g granules, then sizing and pressing into 50 tablets , The tablet weighs 3g. Usage and dosage: poultry, drinking water, add 25 tablets per 100L, stir to dissolve, use for 3~5d.

Embodiment 3

[0020] Example 3: First, add 3g of povidone to 30ml of absolute ethanol, stir thoroughly until it is completely dissolved, and then use it. Take 20g of enrofloxacin hydrochloride raw material, 35g sodium bicarbonate, 25g citric acid, 116.9g soluble starch, 0.1g aspartame was passed through a 60-mesh sieve and mixed evenly, and then granulated with 30ml 10% povidone anhydrous ethanol solution. The ethanol was volatilized by cold wind to make 200g granules, then sizing and pressing into 50 tablets , The tablet weighs 4g. Usage and dosage: poultry, drinking water, add 12.5 tablets per 100L, stir to dissolve, use for 3 to 5 days.

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Abstract

The invention belongs to the field of pharmaceutical preparation, and discloses enrofloxacin effervescent dispersible tablets special for animals and a preparation method of same. The enrofloxacin effervescent dispersible tablets are prepared from the following components in part by weight: 5 to 20 parts of enrofloxacin hydrochloride raw material, 10 to 35 parts of alkaline effervescing agent, 5 to 25 parts of acid effervescing agent, 1 to 3 parts of adhesive, 78.98 to 116.9 parts of filling agent, and 0.02 to 0.1 part of flavoring agent. The enrofloxacin effervescent dispersible tablets prepared by the method have the advantages of convenience in carrying and transportation and high biological availability, and can generate a large number of bubbles in water and also can be dissolved in a short time so as to achieve the characteristics of fast effect and high biological availability. Furthermore, the enrofloxacin effervescent dispersible tablets prepared by the method can generate a large amount of carbon dioxide when being fast dissolved in water, so that the solution becomes acid and can paralyze taste bud to achieve the flavoring effect, and the bitter and astringent taste of the medicament can be improved. Meanwhile, the effervescent dispersible tablets can be directly used without being weighed and are used for disease treatment for an individual farmer or group farmers.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an effervescent dispersible enrofloxacin tablet for livestock and poultry and a preparation method thereof. Background technique [0002] Enrofloxacin is also known as ethyl ciprofloxacin and enrofloxacin. Systematic name: 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. This product is currently designated as a special drug for animals by the state. It belongs to the chemically synthesized bacteriostatic agent of fluoroquinolones. It is a light yellow or light yellow crystalline powder, which is very slightly soluble in water. It can be dissolved in acetic acid, hydrochloric acid or sodium hydroxide solution. Soluble. Its hydrochloride and lactate are easily soluble in water, generally the acid salt is relatively stable, and the solubility of the sodium salt is relatively high. [0003] Enrofloxacin was successfully develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/496A61P31/04
Inventor 贺培益柴保国高义刘升陈圆圆
Owner HENAN SOAR VETERINARY PHARMA
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