An insecticide composition, which uses 0.1-10% of acetamiprid and 5-80% of benzalkonium bromide as the main active ingredients, and is mixed with other auxiliary agents to prepare water emulsion. The present invention has a good curative effect on various diseases such as gill rot and bleeding caused by parasites, bacterial viruses, etc. of various fish, shrimp, crab, soft-shelled turtle, eel, etc., and can effectively kill all kinds of germs harmful to aquatic organisms, Viruses and germs, viruses, harmful bacterial spores, and algae spores that mutate due to environmental deterioration; have a good killing effect on all parasites that harm fish such as trichomonas and ringworms; can also be used for fish, shrimp, crabs, etc. in the mixed culture pond. The invention has wide insecticidal and bactericidal spectrum, safe and reliable use, stable performance and convenient use.