The invention relates to a glass processing device, in particular to a vertical clamping large-size tempered glass homogenization processing device. The technical problem to be solved by the present invention is to provide a vertically clamped large-size tempered glass homogenization processing device. A vertical clamping large-size tempered glass homogenization treatment device, including a quality treatment chamber, a vertical clamping device, an infrared thermometer, a waste removal control device, an eruption gas circulation pipe, a gas push device, an electric heating wire, a waste temporary Storage cabin, high-temperature blower and control panel; an infrared thermometer is installed on the top right side of the homogeneous treatment chamber; the bottom right side of the homogeneous treatment chamber is connected to the waste discharge control device; circulation tube. The invention achieves the effects of spraying hot air on the glass surface to directly heat, increasing the homogenization speed; increasing the glass surface temperature first, shortening the processing time, and reducing the probability of glass injury; and automatically processing glass fragments to prevent the effect of affecting the homogenization process.