The invention discloses a safe guarding device for a power relaying protection field work and a use method thereof. The safe guarding device comprises a guarding device and an isolating device, wherein the guarding device is used for maintaining the work, and the isolating device is used for operating the work. The guarding device for maintaining the work comprises a secondary cable core guardingcap, a guarding cap, a terminal block guarding fence and a protection work voice prompter, which are used for protecting a cable core, a pressing plate and a terminal block. The isolating device for operating the work comprises a protecting screen safety isolating guardrail, a protecting device isolating cover, a protecting pressing plate isolating cover, a terminal block isolating cover, a secondary security isolating cover, a CT externally attached terminal isolating cover, a security temporary storage box, a working signboard and an operation handle isolating cover, which are used for isolating and protecting equipment. Each guarding device is adhered with a marking note corresponding to the work state. The safe guarding device has the advantages of fixation, reliability, obvious mark,simple operation, norm and cleanness, and no influence to operation of the equipment by a magnetic field of a magnet, and is suitable for isolating and protecting various kinds of relay protection equipment and devices.