40results about How to "Consistent stability" patented technology

The invention provides siRNA for inhibiting COL1A1 gene expression. The siRNA comprises a positive-sense strand and an antisense strand, wherein the positive-sense strand comprises a nucleotide sequence I, the antisense strand comprises a nucleotide sequence II, the length of the nucleotide sequence I and the length of the nucleotide sequence II are both 19 nucleotides, and the nucleotide sequenceII is at least partially complementary with a sequence with the length of 19 continuous nucleotides in the region from the 800th locus to the 2200th locus of COL1A1 mRNA. According to the direction from a 5' end to a 3' end, the nucleotides at the 7th, 8th and 9th loci of the nucleotide sequence I are fluoro-modified nucleotides, and the nucleotides at the 2nd, 6th, 14th and 16th loci of the nucleotide sequence II are fluoro-modified nucleotides. The invention further provides a pharmaceutical composition containing the siRNA. The siRNA and the pharmaceutical composition containing the siRNAcan treat or improve diseases related to COL1A1 gene expression.

The invention discloses a method for grafting and fermenting of Pu'er tea. The method comprises the following steps: separately performing withering, enzyme deactivation and rolling treatment on big leaf type Pu'er crude tea of three major tea producing areas including Yunnan Menghai tea area, Pu'er tea area and Lincang tea area, drying, and uniformly mixing; watering the tea leaves mixed uniformly, and then carrying out pile-fermentation to prepare a mother pile of tea leaves; then, with the Yunnan big leaf type Pu'er crude tea as a raw material, preparing Pu'er tea according to a traditionalmethod, and in the fermentation process, turning the pile for 5 times, and from the 3rd to the 5th turning, adding the mother pile of tea leaves and mixing uniformly; and after the tea leaves are un-piled, deblocking and naturally cooling and drying the tea leaves, and further processing to obtain the Pu'er tea. The method is simple and easy to operate, ensures the stable quality of each batch ofproducts, avoids the problems such as acid, throat rubbing, stinging, stabbing, souring, etc., and is suitable for industrial production as well as marketing and application.

The invention relates to the field of production of clean energy, in particular to a plateau oxygen-containing multipurpose agent and plateau oxygen-containing clean diesel containing the plateau oxygen-containing multipurpose agent. The plateau oxygen-containing multipurpose agent consists of the following components in percentage by weight: 26-30% of polyoxymethylene dimethyl ether, 1-3% of ferrocene, 10-15% of xylene, 1-3% of isooctyl nitrate, 8-10% of oleic acid, 1-3% of a detergent, and 40-46% of fatty acid methyl ester. The plateau oxygen-containing clean diesel consists of the following components in percentage by weight: 50-58% of the plateau oxygen-containing multipurpose agent, 8-15% of regenerated diesel, 20-30% of diesel composition oil, and 10-30% of aviation kerosene. The plateau oxygen-containing multipurpose agent and the plateau oxygen-containing clean diesel disclosed by the invention have the advantages of being clean, environmental-friendly, energy-saving and economic, and can reach the effects of improving engine power, being good in stability and reducing exhaust emission.

The invention provides an earth pressure dynamic characteristic modeling method. The earth pressure dynamic characteristic modeling method comprises the steps of collecting historical input and output data of a control system as identification data; determining a soil cabin soil pressure dynamic characteristic ARX model structure of the soil pressure balance shield tunneling machine; and constructing an optimization model of the parameters of the soil pressure ARX model. The invention further provides a shield tunneling machine control system. The shield tunneling machine control system comprises a data acquisition module, a controller, a model training module and a prediction control module. The invention further provides a shield tunneling machine. The shield tunneling machine comprises a shield tunneling machine body, a propelling mechanism and a screw conveyor. According to the method, based on the ARX model, the soil bin pressure and the shield tunneling machine operation parameters are analyzed and modeled, the dynamic mode constraint of the soil pressure system is considered in the model parameter optimization process, and the multi-step forward prediction model of the soil bin soil pressure of the soil pressure balance shield tunneling machine is established, so that the description capability of the model on the dynamic behavior of the soil pressure system is improved. The model established by the invention can be used for designing an earth pressure controller, and provides technical support for effectively controlling the pressure of the sealed cabin of the shield tunneling machine in the tunneling process.

The invention discloses a new aztreonam for injection and a production method thereof. The aztreonam for injection consists of beta crystal form aztreonam and L-arginine, and the weight ratio of the beta crystal form aztreonam to the L-arginine is 1:0.74-1:0.86, wherein the components of aztreonam and L-arginine both need to be ground with the granularity respectively capable of passing a medicinal sieve ranging from 80 meshes to 120 meshes, preferentially a medicinal sieve of 100 meshes. The aztreonam for injection has the advantage of ensuring the crystal form of the aztreonam for injectionsame as that of raw materials, as well as the advantages of accurate rate of two ingredients and subpackage dosage, small subpackage difference among every bottle, uniform mixing, no delamination of two ingredients in production, transportation and storage, and the like. Simultaneously, the invention reduces the impurities of ring-opening aztreonam to some extent.

The invention discloses a preparation method of a cefalexin capsule, and belongs to the technical field of medicines. The method comprises the following steps of: by using cefalexin as a raw material,adding auxiliary materials into the raw material, performing mixing, carrying out dry granulation, filling and packaging to finally obtain a cefalexin capsule preparation, wherein the auxiliary materials include a microcrystalline cellulose-sodium carboxymethylcellulose compound. The national pharmacopoeia standard is met, the effect equal to the quality level of a reference preparation can be achieved, part of quality indexes are even superior to those of the reference preparation, and clinical experiments show that the cefalexin capsule preparation is clinically equivalent to the referencepreparation; and meanwhile, the product quality is improved, consistency evaluation is passed, the method has the advantages of being simple in process, suitable for large-scale industrial productionand the like, and the cefalexin capsule has been commercially produced and sold at present.

The invention discloses a visual detection method for the appearance of a semi-finished battery. The visual detection method comprises the steps that a qualified battery product picture is photographed and registered as a standard picture; the search range is searched for a picture of a product to be detected through a visual controller, wherein the picture is the most similar to the registered standard picture; the similarity of the picture to be detected and the standard picture is calculated; on the basis of picture analysis, the similarity of the product to be detected and the standard picture is judged, and if the similarity is larger than a set value, position offset correction is performed on the obtained picture of the product to be detected; a battery negative electrode cap is detected through a picture processing method, whether flaws exist in the region outside the negative electrode cap or not is detected through a label setting method. The method is good in detection effect and high in precision; the production efficiency is improved, the uncertainty problem of a current manual visual inspection quality control is eradicated, and it is ensured that the stability of batteries produced in different batches is consistent.

The invention provides a method for modeling the dynamic characteristics of earth pressure, which includes collecting historical input and output data of the control system as identification data; determining the ARX model structure of the dynamic characteristics of earth pressure in the soil cabin of the earth pressure balance shield machine; and constructing the parameters of the earth pressure ARX model optimization model. The invention also provides a shield machine control system, which includes a data acquisition module, a controller, a model training module and a predictive control module. The invention also provides a shield machine, which includes a shield machine body, a propulsion mechanism and a screw machine. Based on the ARX model, the present invention analyzes and models the pressure of the soil chamber and the operating parameters of the shield machine, and considers the dynamic mode constraints of the earth pressure system during the optimization process of the model parameters, and establishes the earth pressure balance of the earth pressure of the earth chamber of the shield machine. Step forward prediction model to improve the ability of the model to describe the dynamic behavior of the earth pressure system. The model established by the invention can be used in the design of the earth pressure controller, and provides technical support for effectively controlling the pressure of the sealed cabin of the shield machine during the excavation process.

The invention provides a display device which comprises a display panel and a flexible substrate. A bending area is defined on the flexible substrate, and comprises a first layer and a second layer inthe vertical direction. When the bending area is bent, the first layer is located on the outer layer, and the second layer is located on the inner side of the first layer. The first layer is internally provided with a first metal wire of the first shape. The second layer is internally provided with a second metal wire of the second shape. The length of the first metal wire is larger than the length of the second metal wire. According to the display device, the brand-new dual-layer metal wire shape structure design is adopted for the flexible substrate, the intensity of stress borne by the metal wire on the outer layer of the bending area is effectively improved, the metal wires of the inner layer and the outer layer in the bending area both bear force evenly, and the stability of the metal wires is consistent.

The invention relates to the field of gas sensitive sensors, and in particular relates to an array type smell detecting element based on an MEMS (Micro Electro Mechanical System) technology. The problem that the individuals in the gas sensitive sensor array used by the existing electronic nose are not uniform in response to characteristic drift is solved. The detecting element comprises a semi-conductor substrate, as well as a gas sensitive unit, a temperature sensing unit for detecting the working temperature of the gas sensitive unit, and a heating unit for heating the gas sensitive unit to the needed working temperature, wherein the gas sensitive unit, the temperature sensing unit and the heating unit are obtained by being processed with the MEMS processing technology on the semi-conductor substrate; the gas sensitive unit comprises a plurality of gas sensitive metallic oxide thin films which are arranged in the light of an array; the gas sensitive metallic oxide thin films are different in size parameters but the same in type; and each thin film is provided with two electrodes for connection with data acquisition equipment. The array type smell detecting element is simple in structure and can be realized by being processed with the MEMS technology which is relatively maturely developed; and in addition, the array type smell detecting element is beneficial to the realization of the integration and the miniaturization of the electronic nose and achieves reasonableness in method and correctness in identification.

The invention provides a core-shell-structure silver-gold nanosheet based on epitaxial growth and a preparation method and application thereof. The method includes the steps that firstly, a silver nanosheet solution is prepared, then, chloroauric acid and ligand react in the alkaline environment, and a gold precursor solution is obtained; and a reducing agent, surfactant, a pH modifier, ligand or acetonitrile and the silver nanosheet solution are added to the gold precursor solution, and the core-shell-structure silver-gold nanosheet is obtained after the reaction. The ligand and chloroauric acid radial can generate coordination, a gold precursor is formed, the redox potential of gold is reduced, and the replacement reaction is prevented from being generated; the gold precursor is reduced into gold atoms through the reducing agent, the gold atoms are deposited on the surface layer of a silver nanosheet in an epitaxial growth mode, and the core-shell-structure silver-gold nanosheet is formed. The preparation process is simple and feasible; the shape and the size of the core-shell-structure silver-gold nanosheet are controllable; the excellent stability and the good optical property are achieved; wide application prospects are achieved in the fields of molecular detection and the like.

A vane wrap for a projectile is provided where the wrap includes a base configured to wrap entirely around a circumference of a projectile, such as an arrow, and adhere to the arrow. The base includes an outward facing surface having a set of adhesive strips which are placed in predetermined locations and equally spaced about the circumference when the base is applied to the arrow. Each adhesive strip can include an individual corresponding release liner removable from the strip to expose the respective adhesive for application of a vane thereto, and to the arrow in predetermined locations about a circumference of the arrow. A related method of use also is provided.

The invention belongs to the technical field of formwork support for construction wells, and discloses a climbing system for formwork support in engineering construction wells. The movable frame is provided with a lifting drive mechanism, and the lifting movable frame can be moved along the height direction of the lifting fixed frame through the lifting driving mechanism; the lifting fixed frame is provided with a first wall-attached mechanism, and through the first wall-attached mechanism and Well wall connection of engineering construction wells. The present invention, through the setting of the lifting movable frame and the lifting movable frame and the lifting driving mechanism, can climb step by step during the climbing of the formwork, and has the effects of mutual protection, stable operation and small vibration; by setting the first wall-attached mechanism and the second The second wall-attachment mechanism makes the wall-attachment method novel and can be shared with the reinforcement point of the telescopic formwork, without preset pre-embedding, and has little impact on the wall.

The invention discloses a walnut dew and a preparation method thereof. The walnut dew is composed of 3.5-6% of walnut kernels, 6.5-7.5% of white granulated sugar, 0.1-0.2% of a compound emulsifying thickener, and 0.03-03% of sodium carbonate. 0.05%, the balance is deionized water. Through the reasonable setting of formula and the selection and proportioning of additives, the amount of food additives added can be reduced by more than 50%, reaching only 0.1% of the total amount, and the walnut dew product has good stability and can be stored for a long time.

The invention discloses an anti-frost-cracking water supply pipe, made with, by weight, 60-70 parts of PVC (polyvinyl chloride), 20-30 parts of filler emulsion, 5-10 parts of a compound thermal stabilizer, 1-3 parts of other aids, and 30-40 parts of deionized water. Acidification of kaolin by dilute hydrochloric acid is intended for removing impurities in inner ducts; the surface of kaolin can beorganized; the prepared filler emulsion can more effectively disperse in PVC master batch; the problem that the filler emulsion disperses unevenly in the PVC master batch is solved; the stability levels of all parts of material are uniform; a templating agent is added into a precursor, ordered self-assembly in the material is guided under the acting forces of ionic bond, Van der Waals' force and hydrogen bond, and the inner structure of the material having good compactness and regular structure is formed; the compound thermal stabilizer prepared herein features rarity of separation and good stability, and the problem that the product has poor thermal stability is solved.