Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

55results about How to "Avoid excessive frequency" patented technology

Antibody molecules that bind to il-6 receptor

The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.
Owner:CHUGAI PHARMA CO LTD

Electronic control unit

An electronic control unit (ECU) obtains outside air humidity information from a sensor disposed outside a vehicle compartment and inside air humidity information from a sensor inside the vehicle compartment. The ECU includes a humidity information obtainer obtaining the inside air humidity information, a humidity change calculator calculating the inside air humidity information as a difference between (i) a physical quantity correlated with humidity before a start of a dehumidification or a humidification and (ii) a physical quantity correlated with humidity after a switch-off of the dehumidification or the humidification, a soak time calculator calculating, based on the difference of the physical quantities, a soak time from the switch-off of the dehumidification or the humidification to a sensor-diag startable time at which a diagnosis of the outside air humidity sensor is startable, and a comparator comparing the outside air humidity information and the inside air humidity information after a lapse of the soak time from the switch-off of the dehumidification or the humidification.
Owner:DENSO CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products