The present invention relates to an adhesive composition comprising tannin, polyethylene glycol, and water, wherein the adhesive composition has little toxicity, can be adhered even without a thermosetting curing agent which is different from conventional tannin adhesives, and is poorly soluble in water to be resistant against moisture, and thus can be used as a medical adhesive. The adhesive of the present invention has little toxicity, can be adhered even without a thermosetting curing agent which is different from conventional tannin adhesives, and is poorly soluble in water to be resistant against moisture. Therefore, the adhesive of the present invention can be used as a medical adhesive, an extended release drug delivery system, an adhesion barrier, an agent for preventing the adsorption of cells and proteins, and a medical hemostatic which can be used in various wet environments.