49 results about "Tropisetron Hydrochloride" patented technology

The invention relates to a tropisetron hydrochloride compound. The purity of the tropisetron hydrochloride is greatly improved by acid-base reaction, activated carbon adsorption and separation and purification prepared chromatographic columns, thus optimizing the quality of preparation products and the safety of clinical medication. The method has simple process, low cost and high yield, and is applicable to industrial production.

The invention relates to a detecting method for indole-3-carboxylic acid, in particular to a detecting method for indole-3-carboxylic acid of impurities in tropisetron hydrochloride raw materials and preparations. The detecting method includes the steps: (1) taking the tropisetron hydrochloride raw materials or preparations, performing dissolving and diluting to realize constant volume by means of initial flowing phase, preparing liquor containing 0.5mg of tropisetron hydrochloride per milliliter, and using the liquor as sample liquor by tropisetron; (2) taking indole-3-carboxylic acid reference substances, performing dissolving and diluting to realize constant volume by means of initial flowing phase, preparing liquor containing 0.5mug of indole-3-carboxylic acid per milliliter, and using the liquor as reference substance liquor; and (3) respectively filling 50mul of sample liquor prepared in the step (1) and 50mul of reference substance liquor prepared in the step (2) into a high performance liquid chromatograph for gradient elution. The detecting method has the advantages of high specificity, accuracy in quantification, high sensitivity and stability, and the limit of detectingdrug quality is improved to a high standard.

The invention discloses a preparation method of tropisetron hydrochloride (I). The preparation method comprises using an amide solvent as a solvent to obtain tropisetron hydrochloride through chlorination and esterification. The preparation method disclosed by the invention has the advantages of low cost, simple operation and large-scale production, which lays a solid foundation for the quality research of tropisetron hydrochloride crude drug and related preparations.

The invention relates to a pharmaceutical composition containing containing tropisetron hydrochloride and dexamethasone sodium phosphate, and particularly relates to a combined application package containing a tropisetron hydrochloride injection and a dexamethasone sodium phosphate injection. When the combined application package is in use, the tropisetron hydrochloride injection and the dexamethasone sodium phosphate injection are co-dissolved in normal saline, a Ringer's solution, 5% glucose injection, a fructose solution and the like for intravenous infusion, so that a curative effect of stopping vomit can be increased.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a hydrochloric-acid tropisetron freeze-dried powder injection for injection and a preparation method thereof. The hydrochloric-acid tropisetron freeze-dried powder injection comprises a medicinal active ingredient, excipients and pH (potential of hydrogen) stabilizers, wherein the medicinal active ingredient is hydrochloric-acid tropisetron, the excipients include mannitol and sodium chloride, and the pH stabilizers include citric acid and sodium citrate. According to the hydrochloric-acid tropisetron freeze-dried powder injection, the mannitol and the sodium chloride serve as the excipients, the pH value of a midbody solution is controlled to be stabilized within 4.6-5.2 by citric acid and sodium citrate buffer solutions, oxidation of a main drug is inhibited, and stability of the main drug is improved; in six months of an acceleration test, the injection is stable in content, changes of related substances are small, and the storage period of the injection is prolonged. The preparation method is simple in process and suitable for industrial production.