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Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate

A technology of dexamethasone sodium phosphate and tropane hydrochloride, applied in the field of medicine

Inactive Publication Date: 2014-07-02
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, direct use of tropisetron hydrochloride and dexamethasone still has many side effects, such as constipation, headache, dizziness, vertigo, abdominal pain, glucocorticoid syndrome, etc.

Method used

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  • Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate
  • Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate
  • Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of tropisetron hydrochloride freeze-dried powder injection for injection

[0036] prescription:

[0037]

[0038] Preparation Process:

[0039] (1) First add 2800ml water for injection into the container, and control the temperature at 10℃~20℃;

[0040] (2) Add 105g glycine, stir and dissolve completely;

[0041] (3) Add 7g of tropisetron hydrochloride (press C 17 H 20 N 2 O 2 Calculate), stir and dissolve completely, adjust the pH to 4.9 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0042] (4) Add 0.7g of activated carbon for injection, add the remaining water for injection, dilute to 3500ml, stir and absorb for 30 minutes;

[0043] (5) The solution is coarsely filtered and decarbonized, filtered through a 0.45μm cartridge filter, and then sterilized and filtered with a 0.22μm microporous membrane until the visible foreign matter is qualified;

[0044] (6) Filling.

[0045] (7) Freeze drying

[0046] ① During the pre-freezing peri...

Embodiment 2

[0050] Example 2 Preparation of Tropisetron Hydrochloride Injection

[0051] prescription:

[0052]

[0053] Preparation Process:

[0054] (1) First add 5600ml water for injection into the container, and control the temperature at 10℃~20℃;

[0055] (2) Add 7g of tropisetron hydrochloride (press C 17 H 20 N 2 O 2 Calculate), stir to dissolve completely, adjust the pH to 5.0 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0056] (4) Add 1.4g of activated carbon for injection, add the remaining water for injection, dilute to 7000ml, stir and absorb for 30 minutes;

[0057] (5) The solution is coarsely filtered and decarbonized, filtered through a 0.45μm cartridge filter, and then sterilized and filtered with a 0.22μm microporous membrane until the visible foreign matter is qualified;

[0058] (6) Filling, sealing and sterilization.

Embodiment 3

[0059] Example 3 Preparation of dexamethasone sodium phosphate injection

[0060] prescription:

[0061]

[0062] Preparation Process:

[0063] (1) Add 500ml of water for injection to the beaker, add 2g of sodium bisulfite and 300ml of propylene glycol, stir to dissolve, then add 1g of dexamethasone sodium phosphate, stir to completely dissolve, use 0.1mol / L hydrochloric acid solution or 0.1 Adjust the pH to 7.8 with mol / L sodium hydroxide solution, then add 0.5g of moistened medicinal charcoal, add water for injection to 1000ml, stir for 30 minutes, filter and decarbonize; filter with 0.22μm microporous membrane, Filling, 1ml / bottle, sealing; 121°C autoclave sterilization for 15 minutes, rapid spray cooling, come out of the cabinet, and naturally cool to room temperature.

[0064] (2) Add 500ml of water for injection to the beaker, add 2g of sodium bisulfite and 300ml of propylene glycol, stir to dissolve, then add 2g of dexamethasone sodium phosphate, stir to completely dissolve, ...

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing containing tropisetron hydrochloride and dexamethasone sodium phosphate, and particularly relates to a combined application package containing a tropisetron hydrochloride injection and a dexamethasone sodium phosphate injection. When the combined application package is in use, the tropisetron hydrochloride injection and the dexamethasone sodium phosphate injection are co-dissolved in normal saline, a Ringer's solution, 5% glucose injection, a fructose solution and the like for intravenous infusion, so that a curative effect of stopping vomit can be increased.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition containing tropisetron hydrochloride hydrochloride and dexamethasone sodium phosphate, in particular to a medicinal combination application package composed of tropisetron hydrochloride injection and dexamethasone sodium phosphate injection The composition belongs to the field of medical technology. Background technique [0002] Tropisetron hydrochloride is a highly effective and highly selective competitive antagonist of peripheral neurons and central nervous system serotonin 3 (5-HT3) receptors. Certain substances, including some chemotherapeutics, can stimulate the chromaffin-like cells of the visceral mucosa to release serotonin, thereby inducing the vomiting reflex accompanied by nausea. Tropisetron hydrochloride mainly inhibits the vomiting reflex by selectively blocking the presynaptic 5-HT3 receptors of peripheral neurons. In addition, its antiemetic effect may also be directly blocking ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/661A61P1/08A61K31/46
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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