Pharmaceutical composition containing tropisetron hydrochloride and fructose

A technology for tropisetron hydrochloride and tropisetron hydrochloride, which is applied in the field of medicine and can solve problems such as the occurrence of combined packaging of tropisetron hydrochloride injection

Inactive Publication Date: 2013-11-13
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical use, it is necessary to purchase joint applications separately, and there is no combination package of tropisetron hydrochloride injection and fructose on the market or in medical institutions.

Method used

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  • Pharmaceutical composition containing tropisetron hydrochloride and fructose
  • Pharmaceutical composition containing tropisetron hydrochloride and fructose
  • Pharmaceutical composition containing tropisetron hydrochloride and fructose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Preparation of Tropisetron Hydrochloride for Injection

[0039] prescription:

[0040]

[0041]

[0042] Preparation Process:

[0043] (1) First add 2800ml of water for injection into the container, and control the temperature at 10°C to 20°C;

[0044] (2) Add 35g xylitol and 70g glycine, stir to dissolve completely;

[0045] (3) Add 7g of tropisetron hydrochloride (press C 17 h 20 N 2 o 2 meter), stir to dissolve completely, and adjust the pH to 4.8 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0046] (4) Add 0.7g of activated carbon for injection, add the remaining water for injection, set the volume to 3500ml, stir and absorb for 30 minutes;

[0047] (5) The solution is decarbonized by coarse filtration, coarsely filtered through a 0.45 μm cartridge filter, and then sterilized and filtered with a 0.22 μm microporous membrane until the visible foreign matter is qualified;

[0048] (6) Filling.

[0049] (7) Free...

Embodiment 2

[0058] Example 2 Preparation of Tropisetron Hydrochloride Injection

[0059] prescription:

[0060]

[0061] Preparation Process:

[0062] (1) First add 5600ml of water for injection into the container, and control the temperature at 10°C to 20°C;

[0063] (2) Add 35g xylitol and 70g glycine, stir to dissolve completely;

[0064] (3) Add 7g of tropisetron hydrochloride (press C 17 h 20 N 2 o 2 meter), stir to dissolve completely, and adjust the pH to 5.1 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0065] (4) Add 1.4g of activated carbon for injection, add the remaining water for injection, set the volume to 7000ml, stir and absorb for 30 minutes;

[0066] (5) The solution is decarbonized by coarse filtration, coarsely filtered through a 0.45 μm cartridge filter, and then sterilized and filtered with a 0.22 μm microporous membrane until the visible foreign matter is qualified;

[0067] (6) Filling, sealing, and sterilization.

Embodiment 3

[0072] Example 3 Preparation of Fructose Injection

[0073] prescription:

[0074]

[0075] Preparation Process:

[0076] (1) Concentrated formulation: Add 30L of water for injection into the concentrated formulation tank, add 10,000g of fructose, stir to dissolve, add 100g of wet medicinal charcoal, stir for 30 minutes, filter and decarbonize, filter into the diluted formulation tank, Rinse the concentrated preparation tank with water for injection several times, and filter into the thin preparation tank;

[0077] (2) Dilute formulation: add 90L of water for injection to the dilute formulation tank, adjust the pH value to 4.0 with 0.1mol / L hydrochloric acid solution, add 100g of wet medicinal charcoal, stir for 30 minutes, filter and decarbonize, Add water for injection to 100L;

[0078] (3) Fine filter with 0.22μm microporous membrane, fill, 250ml / bottle and 500ml / bottle, seal;

[0079] (4) Sterilization: Sterilize by autoclaving at 121°C for 15 minutes, quickly spr...

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing a tropisetron hydrochloride injection and a fructose injection, and particularly relates to a composite application package comprising the tropisetron hydrochloride injection and the fructose injection. In use, the tropisetron hydrochloride injection is dissolved into the fructose injection, and then the mixture is used for intravenous infusion. The pharmaceutical composition containing the tropisetron hydrochloride injection and the fructose injection has the effect of treating postoperative nausea and emesis, and also is capable of replenishing energy and body fluid of human body.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing tropisetron hydrochloride and fructose, in particular to a pharmaceutical combination application package composed of tropisetron hydrochloride injection and fructose injection, belonging to the technical field of medicine. Background technique [0002] Tropisetron hydrochloride is a highly efficient and highly selective competitive antagonist of peripheral neurons and central nervous system 5-hydroxytryptamine 3 (5-HT3) receptors. Certain substances, including some chemotherapeutic drugs, stimulate the release of serotonin from chromaffin-like cells in the visceral mucosa, which induces the gag reflex with nausea. Tropisetron hydrochloride inhibits the gag reflex mainly by selectively blocking the presynaptic 5-HT3 receptors of peripheral neurons. In addition, its antiemetic effect may also be related to the direct blockade of central 5-HT3 receptors. Inhibition of the stimulation of th...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P1/08A61P3/02A61K31/46
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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