49 results about "Skin appendage" patented technology

The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids.

Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical compositions containing the same, alone or in combination, for the care of the skin, mucosae and skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.

The present invention is a hair treatment agent comprising a combination of dihydroquercetin and/or a dihydroquercetin derivative with at least one amino acid. A preferred hair treatment agent comprises a combination of dihydroquercetin (taxifolin) with a six-amino acid mixture consisting of taurine, proline, valine, arginine, lysine, and glycine. The inventive hair treatment agent positively influences the natural pigmentation process of skin and skin appendages, such as for example, stimulating melanogenesis and pigmentation of hair, preventing and reducing the graying of hair, and repigmenting gray hair.

Leukemia Inhibitory Factor (“LIF”), an LIF analogue, an LIF mimetic and a product capable of stimulating the expression of endogenous LIF, and mixtures thereof are useful, for (i) promoting the multiplication, in vitro, of a population of human skin stem cells and/or epidermal progenitors while maintaining them in an undifferentiated state, and/or for (ii) maintaining and/or increasing their capacity to generate a pluristratified epithelium, in particular a pluristratified epidermis and/or all or some of the skin appendages; also a library or a culture of human undifferentiated skin stem cells and/or epidermal progenitors is obtained in the presence of LIF, as are reconstructed epidermides and/or reconstructed skin, and kits for producing libraries of cells or reconstructed epidermides, and stem cells or reconstructed epidermides are prepared for the treatment of individuals exhibiting damaged skin (individuals suffering from third degree burns and individuals suffering from genetic diseases affecting the skin).

A method for preparing a composition, comprising a) reducing mother-of-pearl into powder with grain size distribution ranging between about 1 and about 300 μm; b) placing the obtained powder in close contact with an extracting agent in the form of a hydroglycol solution of at least a collagen, of at least a proteoglycan or a mixture thereof; then c) in collecting the extraction mixture, formed by the close contact, constituting the desired composition. The composition obtainable by said method has very interesting properties relative to the skin and/or skin appendages, in particular tissue-regenerating properties, enabling for instance improved wound healing, and anti-ageing properties for preventing and/or visibly reducing effects related to skin and/or skin appendage ageing.

The invention discloses an extraction process of organism diamond raw material carbon. The extraction process comprises the following steps: performing high temperature carbonization to the skin appendages of human or animals under the protection of inert gas or nitrogen; then removing impurities from the carbonized material through a chemical method; and finally drying the purified material. The extraction process of the invention has low raw material cost, convenient operation, high extraction efficiency and good extraction effect; and pure carbon can be prepared and the carbon can be used to prepare an organism diamond souvenir which has a special emotional significance and good commercial value.

The invention discloses a targeted gold nano-cone composite material used for photothermal therapy, and a preparation method and applications thereof. The targeted gold nano-cone composite material comprises a gold nano-cone, the outer surface of the gold nano-cone is coated with pre-treated bovine serum albumin, and the surface of each gold nano-cone particle is modified by a targeting molecule.The targeted gold nano-cone composite material is used in the preparation of a product for photothermal therapy on tumors, wherein the tumor is skin cancer (including epidermis, skin appendages, melanocytes and hematopoietic tissues) and breast cancer. The gold nano-cone composite material prepared by the invention is protected by the pretreated bovine serum albumin (BSA), and has high biocompatibility and good stability. The gold nano-cone composite material prepared by the invention can modify a plurality of targeted biomolecules, and can realize precise photothermal therapy on tumors. The composite material is relatively simple in preparation steps and good in repeatability, can be used for early treatment of cancers, and is a new technical means for clinical cancer treatment.

The invention discloses a medicine for accelerating the repair of stratum epidermis and the regeneration of skin appendages. The medicine consists of epidermal stem cells, bone marrow mesenchymal stem cells and a medicine carrier, wherein the epidermal stem cells and the bone marrow mesenchymal stem cells are adhered to the medicine carrier, namely each cubic millimeter of the medicine carrier contains (0.3-1)*104 epidermal stem cells and (0.3-1)*104 bone marrow mesenchymal stem cells. The medicine has an obvious effect in aspects of promoting the regeneration of the stratum epidermis, promoting the regeneration of dermis, enhancing the mechanical strength of regenerated skin, promoting the content of collagen of the regenerated skin, promoting revascularization, promoting the regeneration of hair follicles and the like, so that wounds can be repaired within a short time and the regeneration of the skin appendages can be accelerated. The invention also discloses a method for preparing the medicine for accelerating the repair of the stratum epidermis and the regeneration of the skin appendages, and the method is simple, high in controllability, high in operability and high in repeatability.

The invention provides an isolated culture method of hair follicle stem cells of Yangtze River delta white goat. By adoption of the method, an isolated cell line has a good growth and division state,and relatively pure hair follicle stem cells can be obtained and are of a typical paving stone shape; primary cells grow fast, so that aggregated growth of cells can be observed on the third day, morecell aggregates in aggregated growing can be observed on the fourth day, the cells can overgrow 60 to 70 percent of a culture dish on the fifth day, and the positive rate of hair follicle stem cell markers is up to 90 percent or above. Results of cell chromosome analysis, hair follicle stem cell marker detection, cell activity detection and the like show that a built hair follicle stem cell lineof the Yangtze River delta white goat is high in activity, and the hair follicle stem cell markers are high in positive rate; and a good practical model can be provided for researching gene expressionand passageway regulation of skin cells and growth and a mechanisms of skin appendages, in particular for researching a mutual action mechanism among main cells of the skin.

The invention relates to a method for constructing a biological 3D printing skin microcell model containing skin appendages. The method comprises the following steps: 1) preparing a biological 3D printing rubber block containing seed cells of sweat gland tissues, and hanging and planting hair follicles and sebaceous glands on the biological 3D printing rubber block; 2) performing induction cultureon the biological 3D printing rubber block by using an induction culture medium; wherein the induction culture medium comprises a sweat gland induction culture medium, a hair follicle induction culture medium and a sebaceous gland induction culture medium; and 3) after induction culture for 5-10 days, adding epidermal stem cells to a surface of the biological 3D printing rubber block, and performing gas-liquid planar cultivation to form biological 3D printing skin microcell. The skin microcell model prepared by the method realizes synchronous regeneration of dermis and epidermis of the skin and various skin appendages.

The invention discloses a method for preparing an isolated hair follicle in a process of treating scar by hair follicle stem cell transplantation. The method comprises the following steps: extractionof hair follicles, separation of the hair follicles, completely separating the hair follicle units into single hair follicles under an electron microscope, and keeping the extracted skin appendages such as sebaceous glands, sweat glands and the like as far as possible; for scars in a smooth hairless area, removing lower 1/3 of hair papilla, so that the hair follicle could not enter the next growthcycle, and no final hair grows in the scar area; in vitro culture of the hair follicles, putting the isolated single hair follicle into a special culture solution for culturing for later use; planting the hair follicle stem cells in a specific area of the scar on the basis of hair follicles. According to the method, through a hair follicle in-vitro culture technology, the single hair follicle isseparated and inactivated by adopting a separation method different from a hair transplantation operation, and is cultured in the special culture solution, so that growth and proliferation of hair follicle stem cells are facilitated. The method can achieve purposes of inhibiting scar hyperplasia, softening and repairing scars, and removing and beautifying scars.

The invention relates to a cosmetic or dermatological composition containing a polyphenol-enriched extract of Vitex Negundo, typically a root extract obtained using a PAT plant milking process. The invention further relates to a composition of this kind for use in the prevention or treatment of disorders and diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of extrinsic or intrinsic skin aging. Lastly, the invention relates to a cosmetic care method for the skin, skin appendages or mucous membranes, with a view to improving the condition or appearance thereof, said method consisting in administering such a composition or such an extract.

The invention relates to 3D-printed artificial skin. The 3D-printed artificial skin comprises a keratinocyte containing hydrogel layer, a woven layer, a hair follicle cell containing hydrogel layer and another woven layer in sequence from top to bottom; the woven layers are formed by weaving macromolecule degradable materials and contain pores; the keratinocyte containing hydrogel layer and the hair follicle cell containing hydrogel layer both contain epidermal growth factors and nano-silver. The 3D-printed artificial skin has the advantages that the adopted materials are macromolecule degradable materials which are easy to obtain and good in biocompatibility, and the woven layers obtained through weaving have many pores which are beneficial for transport and exchange of nutrient substances; due to a multi-layer structure, the wear resistance, toughness, mechanical strength and other physical properties of the artificial skin are enhanced; through normal-pressure plasma jet treatment, the superficial areas of the woven layers are increased, and adhesion between hydrogel and skin appendage cells is promoted; the artificial skin primarily has a normal skin structure after being manufactured, and recovery of skin functions is convenient.