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49 results about "Skin appendage" patented technology
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Skin appendages (or adnexa) are skin-associated structures that serve a particular function including sensation, contractility, lubrication and heat loss. In humans, some of the more common skin appendages are hairs (sensation, heat loss, filter for breathing, protection), arrector pilli (smooth muscles that pull hairs straight), sebaceous glands (secrete sebum onto hair follicle, which oils the hair), sweat glands (can secrete sweat with strong odour (apocrine) or with a faint odour (merocrine or eccrine)), and nails (protection).
Taurine-containing preparations for improving the skin barrier
InactiveUS20050238679A1Increased osmolarityVolume stabilityBiocideCosmetic preparationsPlant sterolCholesterol
The invention is a cosmetic or dermatological preparation comprising taurine and at least one substance selected from the group consisting of phytosterols, ceramides, long-chain fatty acids, and cholesterol. The invention also includes a method of strengthening the skin barrier comprising applying to the skin a preparation comprising taurine and at least one substance selected from the group consisting of phytosterols, ceramides, long-chain fatty acids, and cholesterol. The invention also includes methods of moisturizing the skin, improving the microtopography of the skin, improving the elasticity of the skin, treating or preventing functional disorders of skin appendages, treating or preventing the symptoms of skin ageing, and treating or preventing the harmful effects of ultraviolet radiation on the skin comprising applying the preparation.
Owner:BEIERSDORF AG
Topical pharmaceutical composition based on semifluorinated alkanes
The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids.
Owner:DERMALIQ THERAPEUTICS INC
Cosmetic or dermopharmaceutical compositions containing kombucha
Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical compositions containing the same, alone or in combination, for the care of the skin, mucosae and skin appendages, and in particular for preventing the signs of endogenous and / or exogenous ageing.
Owner:SEDERMA SA
Polysiloxanes having quaternary ammonium groups, method for producing same and use thereof in formulations for cleansing and care
InactiveUS8778319B2Good conditionPleasant, velvety-silky skin feelBiocideSilicon organic compoundsMedicineAdditive ingredient
Owner:EVONIK DEGUSSA GMBH
Use of dihydroquercetin and at least one amino acid to positively influence the natural pigmentation process
The present invention is a hair treatment agent comprising a combination of dihydroquercetin and / or a dihydroquercetin derivative with at least one amino acid. A preferred hair treatment agent comprises a combination of dihydroquercetin (taxifolin) with a six-amino acid mixture consisting of taurine, proline, valine, arginine, lysine, and glycine. The inventive hair treatment agent positively influences the natural pigmentation process of skin and skin appendages, such as for example, stimulating melanogenesis and pigmentation of hair, preventing and reducing the graying of hair, and repigmenting gray hair.
Owner:HENKEL KGAA
Topical pharmaceutical composition based on semifluorinated alkanes
The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids.
Owner:DERMALIQ THERAPEUTICS INC
Novel polysiloxanes having betaine groups, production and use thereof
The invention relates to new types of polysiloxanes which contain at least one betaine group, and to a process for the preparation thereof. It also relates to the use of these polymers as care active ingredient in formulations, in particular for the care and cleaning of skin and skin appendages, such as, for example, as conditioning agent for hair. In addition, the invention relates to the formulations comprising these new types of compounds.
Owner:EVONIK DEGUSSA GMBH
Cell and tissue engineering utilizing LIF
InactiveUS20060014282A1Promotes epidermal reconstitutionQuality improvementMicrobiological testing/measurementEpidermal cells/skin cellsEpitheliumProgenitor
Leukemia Inhibitory Factor (“LIF”), an LIF analogue, an LIF mimetic and a product capable of stimulating the expression of endogenous LIF, and mixtures thereof are useful, for (i) promoting the multiplication, in vitro, of a population of human skin stem cells and / or epidermal progenitors while maintaining them in an undifferentiated state, and / or for (ii) maintaining and / or increasing their capacity to generate a pluristratified epithelium, in particular a pluristratified epidermis and / or all or some of the skin appendages; also a library or a culture of human undifferentiated skin stem cells and / or epidermal progenitors is obtained in the presence of LIF, as are reconstructed epidermides and / or reconstructed skin, and kits for producing libraries of cells or reconstructed epidermides, and stem cells or reconstructed epidermides are prepared for the treatment of individuals exhibiting damaged skin (individuals suffering from third degree burns and individuals suffering from genetic diseases affecting the skin).
Owner:LOREAL SA
Tissue engineering skin and preparation method thereof
The invention discloses tissue engineering skin which comprises seed cells and an acellular allogenic dermal matrix, wherein the seed cells and the acellular allogenic dermal matrix form a skin appendage; the seed cells are arranged, spread flat and printed at corresponding positions on the front side of the acellular allogenic dermal matrix according to an anatomical structure of normal skin by using a 3D (Three-dimensional) printer. The invention also discloses a method for preparing the tissue engineering skin. The invention provides perfect tissue engineering skin, and the tissue engineering skin can be rapidly constructed in a short time in an operating room (the operation is finished). Meanwhile, the tissue engineering skin comprises the seed cells and dermal matrix, the seed cells are basal layer cells, have the activities of multipotential stem cells and multipotential differentiation functions and are arranged and printed in the corresponding positions according to the anatomical structure of the normal skin, the skin appendage is easily formed, the cure rate is accelerated after the operation, and functions of the skin are restored.
Owner:广州市麦施缔医疗科技有限公司
Preparation, in particular cosmetic preparation, and the production and use thereof
A preparation, in particular a cosmetic preparation, preferably in liquid or pasty form, for use on keratinic materials, in particular for decorating, coloring, improving the appearance of and caring for the skin and the skin appendages. The preparation is water-free and contains at least one wax with a dropping point above 60° C., a volatile oil, a non-volatile oil, an alkyl polysiloxane, an alcohol which is solid at ambient temperature, and a film-forming, flexible copolymer with a dropping point above 30° C.
Owner:SCHWAN STABILO COSMETICS
Method for preparing a composition by extraction of mother-of-pearl, composition obtained by said method and use thereof in cosmetics and dermatology
InactiveUS6936280B1Preventing and delaying effect of agingCosmetic preparationsBiocideAnti ageingClose contact
A method for preparing a composition, comprising a) reducing mother-of-pearl into powder with grain size distribution ranging between about 1 and about 300 μm; b) placing the obtained powder in close contact with an extracting agent in the form of a hydroglycol solution of at least a collagen, of at least a proteoglycan or a mixture thereof; then c) in collecting the extraction mixture, formed by the close contact, constituting the desired composition. The composition obtainable by said method has very interesting properties relative to the skin and / or skin appendages, in particular tissue-regenerating properties, enabling for instance improved wound healing, and anti-ageing properties for preventing and / or visibly reducing effects related to skin and / or skin appendage ageing.
Owner:CENT NAT DE LA RECHERCHE SCI
Extraction process of organism diamond raw material carbon
The invention discloses an extraction process of organism diamond raw material carbon. The extraction process comprises the following steps: performing high temperature carbonization to the skin appendages of human or animals under the protection of inert gas or nitrogen; then removing impurities from the carbonized material through a chemical method; and finally drying the purified material. The extraction process of the invention has low raw material cost, convenient operation, high extraction efficiency and good extraction effect; and pure carbon can be prepared and the carbon can be used to prepare an organism diamond souvenir which has a special emotional significance and good commercial value.
Owner:李立华 +1
Targeted gold nano-cone composite material used for photothermal therapy, and preparation method and applications thereof
InactiveCN109701017AGood biocompatibilityImprove stabilityEnergy modified materialsPharmaceutical non-active ingredientsBiocompatibility TestingBovine serum albumin
Owner:HUBEI UNIV OF TECH
Preparation, in particular cosmetic preparation, and the production and use thereof
Owner:SCHWAN STABILO COSMETICS
Topical pharmaceutical composition based on semifluorinated alkanes
Owner:DERMALIQ THERAPEUTICS INC
Medicine for accelerating skin repair and regeneration, preparation method thereof and application thereof
ActiveCN102552323APromote repairEasily damagedUnknown materialsMacromolecular non-active ingredientsSkin repairOperability
The invention discloses a medicine for accelerating the repair of stratum epidermis and the regeneration of skin appendages. The medicine consists of epidermal stem cells, bone marrow mesenchymal stem cells and a medicine carrier, wherein the epidermal stem cells and the bone marrow mesenchymal stem cells are adhered to the medicine carrier, namely each cubic millimeter of the medicine carrier contains (0.3-1)*104 epidermal stem cells and (0.3-1)*104 bone marrow mesenchymal stem cells. The medicine has an obvious effect in aspects of promoting the regeneration of the stratum epidermis, promoting the regeneration of dermis, enhancing the mechanical strength of regenerated skin, promoting the content of collagen of the regenerated skin, promoting revascularization, promoting the regeneration of hair follicles and the like, so that wounds can be repaired within a short time and the regeneration of the skin appendages can be accelerated. The invention also discloses a method for preparing the medicine for accelerating the repair of the stratum epidermis and the regeneration of the skin appendages, and the method is simple, high in controllability, high in operability and high in repeatability.
Owner:ZHEJIANG UNIV
Tissue engineering skin constructed by sodium alginate hydrogel scaffold and preparation method thereof
The invention discloses tissue engineering skin constructed by a sodium alginate hydrogel scaffold. The tissue engineering skin comprises a cuticular layer and a corium layer from top to bottom, wherein the cuticular layer is a layer of seed cells positioned above the corium layer; and the corium layer comprises seed cells and a sodium alginate hydrogel scaffold; the seed cells are positioned in the surface and body of the sodium alginate hydrogel scaffold to form a skin appendage. Since the hydrogel scaffold cross-linked network contains a great amount of moisture, can be used for supplying nutrition to cells, and is crosslinked with EGF to adjust growth and differentiation of cells, so that the hydrogel scaffold can be used for well simulating tissue-like physical and spatial structures essential to cell growth, a three-dimensional cultural space of cells can be provided, culture and function maintenance of stratum basale epidermidis cells can be benefited, and a tissue engineering skin substitute with biological activity can be constructed. When the tissue engineering skin is applied to a wound surface, and recovery of a normal tissue structure of the wound is benefited.
Owner:朱家源 +1
Isolated culture method of hair follicle stem cells of Yangtze River delta white goat
InactiveCN109355255AOptimize the extraction processAvoid timeCell dissociation methodsDead animal preservationPhysiologyStem cell line
The invention provides an isolated culture method of hair follicle stem cells of Yangtze River delta white goat. By adoption of the method, an isolated cell line has a good growth and division state,and relatively pure hair follicle stem cells can be obtained and are of a typical paving stone shape; primary cells grow fast, so that aggregated growth of cells can be observed on the third day, morecell aggregates in aggregated growing can be observed on the fourth day, the cells can overgrow 60 to 70 percent of a culture dish on the fifth day, and the positive rate of hair follicle stem cell markers is up to 90 percent or above. Results of cell chromosome analysis, hair follicle stem cell marker detection, cell activity detection and the like show that a built hair follicle stem cell lineof the Yangtze River delta white goat is high in activity, and the hair follicle stem cell markers are high in positive rate; and a good practical model can be provided for researching gene expressionand passageway regulation of skin cells and growth and a mechanisms of skin appendages, in particular for researching a mutual action mechanism among main cells of the skin.
Owner:YANGZHOU UNIV
Method for constructing biological 3D printing skin microcell model containing skin appendage
ActiveCN111330082ABreak through the difficulty of synchronous regenerationAdditive manufacturing apparatusProsthesis3d printSweat gland
The invention relates to a method for constructing a biological 3D printing skin microcell model containing skin appendages. The method comprises the following steps: 1) preparing a biological 3D printing rubber block containing seed cells of sweat gland tissues, and hanging and planting hair follicles and sebaceous glands on the biological 3D printing rubber block; 2) performing induction cultureon the biological 3D printing rubber block by using an induction culture medium; wherein the induction culture medium comprises a sweat gland induction culture medium, a hair follicle induction culture medium and a sebaceous gland induction culture medium; and 3) after induction culture for 5-10 days, adding epidermal stem cells to a surface of the biological 3D printing rubber block, and performing gas-liquid planar cultivation to form biological 3D printing skin microcell. The skin microcell model prepared by the method realizes synchronous regeneration of dermis and epidermis of the skin and various skin appendages.
Owner:GENERAL HOSPITAL OF PLA
Use of a griffonia extract, in particular griffonia simplicifolia, in a cosmetic or dermatological composition for mitigating pigmentation of skin and skin appendages
The invention concerns the use of a Griffonia extract, in particular Griffonia simplicifolia, in a cosmetic or dermatological composition for mitigating pigmentation of skin and skin appendages. Said cosmetic or dermatological composition may also contain one or other of the following products: at least one active depigmenting product, at least one substance for filtering or blocking ultraviolet B and / or A rays, at least one anti-inflammatory product, at least one desquamation promoting agent. It contains 0.05 to 20 wt. % of a Griffonia simplicifolia extract.
Owner:AM PHYTO CONSEIL
Method for preparing isolated hair follicle in process of treating scar by hair follicle stem cell transplantation
PendingCN111202750AAvoid damagePreserve tissue componentsCell dissociation methodsEpidermal cells/skin cellsSweat glandElectron microscopic
The invention discloses a method for preparing an isolated hair follicle in a process of treating scar by hair follicle stem cell transplantation. The method comprises the following steps: extractionof hair follicles, separation of the hair follicles, completely separating the hair follicle units into single hair follicles under an electron microscope, and keeping the extracted skin appendages such as sebaceous glands, sweat glands and the like as far as possible; for scars in a smooth hairless area, removing lower 1 / 3 of hair papilla, so that the hair follicle could not enter the next growthcycle, and no final hair grows in the scar area; in vitro culture of the hair follicles, putting the isolated single hair follicle into a special culture solution for culturing for later use; planting the hair follicle stem cells in a specific area of the scar on the basis of hair follicles. According to the method, through a hair follicle in-vitro culture technology, the single hair follicle isseparated and inactivated by adopting a separation method different from a hair transplantation operation, and is cultured in the special culture solution, so that growth and proliferation of hair follicle stem cells are facilitated. The method can achieve purposes of inhibiting scar hyperplasia, softening and repairing scars, and removing and beautifying scars.
Owner:刘景卫
Polypeptide hydrogel for promoting skin repair as well as preparation method and application thereof
ActiveCN113493492APromote healingPromote generationPeptide/protein ingredientsAerosol deliverySkin repairCD31
The invention relates to the field of pharmaceutical preparations, in particular to polypeptide hydrogel for promoting skin repair and a preparation method and application thereof. The invention provides a self-assembled peptide, and also provides a polypeptide hydrogel formed by an aqueous solution of the self-assembled peptide. The invention also provides a method for preparing the polypeptide hydrogel. The invention also provides an application of the polypeptide hydrogel in treatment of skin injury of diabetic mice. The polypeptide hydrogel can promote healing of injured skin of diabetic mice and generation of skin appendages, improve the positive rate of PCNA cells and promote accumulation of CD31 positive blood vessels and collagen. The invention also provides an application of the polypeptide hydrogel in in-vitro cell 3D culture, wherein the HaCaT cells of the human keratinocyte line grow spherically in the polypeptide hydrogel, and the expression levels of PDGF and VEGF of the cells are higher than those of two-dimensional cultured cells.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
Novel cosmetic and dermatological uses of an extract of cistus monspeliensis
PendingUS20220241181A1Reduce the amount requiredCosmetic preparationsToilet preparationsDiseaseLipoxin
Novel cosmetic and dermatological uses of an extract of Cistus monspeliensis The invention relates to the non-therapeutic cosmetic use of an extract of Cistus monspeliensis for increasing and / or maintaining tissue homeostasis in the skin and / or the mucous membranes and / or the skin appendages, by increasing and / or maintaining the barrier function and / or cell differentiation in the skin and / or the mucous membranes and / or the skin appendages. Another subject relates to a non-therapeutic cosmetic care process notably comprising the topical application of the extract of C. monspeliensis or of a cosmetic composition comprising same. Yet another subject relates to the extract of C. monspeliensis, for its use for preventing and / or treating diseases induced by a decrease in the gene and / or protein expression of ECM1, advantageously lichen sclerosus or lipoid proteinosis, and / or for preventing and / or treating scars.
Owner:BASF BEAUTY CARE SOLUTIONS FRANCE SAS
Dermatological or cosmetic compositions containing polyphenol-enriched extract of vitex negundo
The invention relates to a cosmetic or dermatological composition containing a polyphenol-enriched extract of Vitex Negundo, typically a root extract obtained using a PAT plant milking process. The invention further relates to a composition of this kind for use in the prevention or treatment of disorders and diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of extrinsic or intrinsic skin aging. Lastly, the invention relates to a cosmetic care method for the skin, skin appendages or mucous membranes, with a view to improving the condition or appearance thereof, said method consisting in administering such a composition or such an extract.
Owner:LAB EXPANSCIENCE
3D printing rapidly constructed tissue engineered skin and its preparation method
The invention discloses tissue engineering skin which comprises seed cells and an acellular allogenic dermal matrix, wherein the seed cells and the acellular allogenic dermal matrix form a skin appendage; the seed cells are arranged, spread flat and printed at corresponding positions on the front side of the acellular allogenic dermal matrix according to an anatomical structure of normal skin by using a 3D (Three-dimensional) printer. The invention also discloses a method for preparing the tissue engineering skin. The invention provides perfect tissue engineering skin, and the tissue engineering skin can be rapidly constructed in a short time in an operating room (the operation is finished). Meanwhile, the tissue engineering skin comprises the seed cells and dermal matrix, the seed cells are basal layer cells, have the activities of multipotential stem cells and multipotential differentiation functions and are arranged and printed in the corresponding positions according to the anatomical structure of the normal skin, the skin appendage is easily formed, the cure rate is accelerated after the operation, and functions of the skin are restored.
Owner:广州市麦施缔医疗科技有限公司
Preparation method and application of novel medical antibacterial healing-promoting hydrogel dressing
InactiveCN111228564AInhibition of rapid contractionAvoid pollutionBandagesMatrigelAntibacterial activity
The invention discloses a preparation method and application of a novel medical antibacterial healing-promoting hydrogel dressing. The novel medical antibacterial healing-promoting hydrogel dressing comprises an antibacterial healing-promoting hydrogel dressing body and distilled water, and the antibacterial healing-promoting hydrogel dressing body is composed of distilled water, polyacrylamide, quaternized chitosan and matrigel. Matrigel and quaternized chitosan are adopted, the matrigel not only promotes formation of epithelization, vascularization and nervalization of a wound surface, but also can induce regeneration of skin appendages such as hair follicle sweat glands and the like and better recover tissue appearance and functions; the quaternized chitosan is a chitosan derivative with the strongest antibacterial effect and has broad-spectrum antibacterial activity; and a three-dimensional porous network structure of the polyacrylamide can provide a good microenvironment for migration and proliferation of repair cells, can inhibit rapid contraction of the wound surface and improve the repair effect, is good in mechanical strength, and can just make up the defect of poor mechanical strength of a natural polymer. Complementary advantages of the three components are achieved, and the repair effect of the wound surface is improved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
3D-printed artificial skin and preparation method
The invention relates to 3D-printed artificial skin. The 3D-printed artificial skin comprises a keratinocyte containing hydrogel layer, a woven layer, a hair follicle cell containing hydrogel layer and another woven layer in sequence from top to bottom; the woven layers are formed by weaving macromolecule degradable materials and contain pores; the keratinocyte containing hydrogel layer and the hair follicle cell containing hydrogel layer both contain epidermal growth factors and nano-silver. The 3D-printed artificial skin has the advantages that the adopted materials are macromolecule degradable materials which are easy to obtain and good in biocompatibility, and the woven layers obtained through weaving have many pores which are beneficial for transport and exchange of nutrient substances; due to a multi-layer structure, the wear resistance, toughness, mechanical strength and other physical properties of the artificial skin are enhanced; through normal-pressure plasma jet treatment, the superficial areas of the woven layers are increased, and adhesion between hydrogel and skin appendage cells is promoted; the artificial skin primarily has a normal skin structure after being manufactured, and recovery of skin functions is convenient.
Owner:ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
Surgical instrument for grinding scabs of burn wounds
ActiveCN102247178BImprove cleanlinessAvoid sticking to the grinding surfaceSurgeryNecrotic tissueHealthy tissue
The invention discloses a surgical instrument for grinding scabs of burn wounds, which is characterized by being made of a stainless steel plate, wherein the left side and right side of the stainless steel plate are fixedly connected; a grinding surface composed of a plurality of hollowed-out bulges is formed at the upper part of the stainless steel plate; and a hollow smooth handle is arranged at the lower part of the stainless steel plate. The surgical instrument disclosed by the invention has the advantage of reasonable structure and has the functions of thoroughly eliminating necrotic tissues, reserving more healthy tissues and skin appendages and promoting the healing of deep burn wounds.
Owner:潘银根 +1
Medicine for accelerating skin repair and regeneration, preparation method thereof and application thereof
ActiveCN102552323BPromote regenerationIncrease contentUnknown materialsDermatological disorderSkin repairOperability
The invention discloses a medicine for accelerating the repair of stratum epidermis and the regeneration of skin appendages. The medicine consists of epidermal stem cells, bone marrow mesenchymal stem cells and a medicine carrier, wherein the epidermal stem cells and the bone marrow mesenchymal stem cells are adhered to the medicine carrier, namely each cubic millimeter of the medicine carrier contains (0.3-1)*104 epidermal stem cells and (0.3-1)*104 bone marrow mesenchymal stem cells. The medicine has an obvious effect in aspects of promoting the regeneration of the stratum epidermis, promoting the regeneration of dermis, enhancing the mechanical strength of regenerated skin, promoting the content of collagen of the regenerated skin, promoting revascularization, promoting the regeneration of hair follicles and the like, so that wounds can be repaired within a short time and the regeneration of the skin appendages can be accelerated. The invention also discloses a method for preparing the medicine for accelerating the repair of the stratum epidermis and the regeneration of the skin appendages, and the method is simple, high in controllability, high in operability and high in repeatability.
Owner:ZHEJIANG UNIV
Preparation, in particular cosmetic preparation, and the production and use thereof
Owner:SCHWAN STABILO COSMETICS
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