Preparation method and application of novel medical antibacterial healing-promoting hydrogel dressing

Abstract

The invention discloses a preparation method and application of a novel medical antibacterial healing-promoting hydrogel dressing. The novel medical antibacterial healing-promoting hydrogel dressing comprises an antibacterial healing-promoting hydrogel dressing body and distilled water, and the antibacterial healing-promoting hydrogel dressing body is composed of distilled water, polyacrylamide, quaternized chitosan and matrigel. Matrigel and quaternized chitosan are adopted, the matrigel not only promotes formation of epithelization, vascularization and nervalization of a wound surface, but also can induce regeneration of skin appendages such as hair follicle sweat glands and the like and better recover tissue appearance and functions; the quaternized chitosan is a chitosan derivative with the strongest antibacterial effect and has broad-spectrum antibacterial activity; and a three-dimensional porous network structure of the polyacrylamide can provide a good microenvironment for migration and proliferation of repair cells, can inhibit rapid contraction of the wound surface and improve the repair effect, is good in mechanical strength, and can just make up the defect of poor mechanical strength of a natural polymer. Complementary advantages of the three components are achieved, and the repair effect of the wound surface is improved.

Description

technical field [0001] The invention relates to the technical field of wound repair, in particular to a preparation method and application of a novel medical antibacterial and healing-promoting hydrogel dressing. Background technique [0002] Wound repair has always been a common problem in orthopedics, plastic surgery, and hand surgery. There are many repair methods for skin and soft tissue wounds, including skin grafting, skin flaps, or skin stretch closure. In addition, tissue engineering methods to solve wound repair problems are becoming more and more It is becoming more and more extensive, and some repair effects can reach a very good level. The representative types include hydrogel, artificial dermis, acellular matrix, etc. The main purpose is to build a microenvironment conducive to wound repair and promote related wound repair. Repair the proliferation, migration and differentiation of cells, so as to achieve the purpose of closing the wound, but some synthesis meth...

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Problems solved by technology

[0002] Wound repair has always been a common problem in orthopedics, plastic surgery, and hand surgery. There are many repair methods for skin and soft tissue wounds, including skin grafting, skin flaps, or skin stretch closure. In addition, tissue engineering methods to solve wound repair problems are becoming more and more It is becoming more and more extensive, and some repair effects can reach a very good level. The representative types include hydrogel, artificial dermis, acellular matrix, etc. The main purpose is to build a microenvironment conducive to wound repair and promote related wound repair. Repair the proliferation, migration and differentiation of cells, so as to achieve the purpose of closing the wound, but some synthesis methods are complicated, and the raw materials are expensive, which is not suitable for large-scale clinical application. This method will cause tissue loss and scar formation in the donor area, which will affect the appearance and function. Therefore, if there is a tissue engineering product that is easy to prepare, economical and effective, and has a good repair effect, it will greatly benefit the majority of patients.

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