Preparation method and application of novel medical antibacterial healing-promoting hydrogel dressing

A hydrogel, a new type of technology, applied in medical science, bandages, etc., can solve the problems of affecting appearance and function, complex synthesis method, loss of tissue in the donor area, etc., and achieve low production cost, simple mixing method, and inhibition of rapid contraction. Effect

Inactive Publication Date: 2020-06-05
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Wound repair has always been a common problem in orthopedics, plastic surgery, and hand surgery. There are many repair methods for skin and soft tissue wounds, including skin grafting, skin flaps, or skin stretch closure. In addition, tissue engineering methods to solve wound repair problems are becoming more and more It is becoming more and more extensive, and some repair effects can reach a very good level. The representative types include hydrogel, artificial dermis, acellular matrix, etc. The main purpose is to build a microenvironment conducive to wound repair and promote related wound repair. Repair the proliferation, migration and differentiation of cells, so as to achieve the purpose of closing the wound, but some synthesis methods are complicated, and the raw materials are expensive, which is not suitable for large-scale clinical application. This method will cause tissue loss and scar formation in the donor area, which will affect the appearance and function. Therefore, if there is a tissue engineering product that is easy to prepare, economical and effective, and has a good repair effect, it will greatly benefit the majority of patients.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of novel medical antibacterial healing-promoting hydrogel dressing
  • Preparation method and application of novel medical antibacterial healing-promoting hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one, with reference to Figure 1-2 Take an appropriate amount of quaternized chitosan in a granular solid state in proportion and place it inside the stirring container, inject 30% of the total volume of distilled water into the container, stir while adding, and form a quaternized chitosan aqueous solution. Stirring is continued until the quaternized chitosan aqueous solution has no precipitation, and the stirring and mixing are completed. This process is completed in a sterile environment, and the temperature environment is 40°C-50°C.

Embodiment 2

[0026] Embodiment two, refer to Figure 1-2 , take an appropriate amount of polyacrylamide whose initial state is granular and solid in proportion, and place it inside the stirring container, inject 30% of the total volume of distilled water into the container, stir while adding, and form an aqueous solution of polyacrylamide, and continue stirring until the polyacrylamide There is no precipitation in the aqueous solution, and the stirring and mixing are completed. This process is completed in a sterile environment, and the temperature environment is 40°C-50°C.

Embodiment 3

[0027] Embodiment three, refer to Figure 1-2 , add the mixed polyacrylamide aqueous solution and quaternized chitosan aqueous solution to the remaining 40% distilled water, stir while adding, after the addition, continue stirring for 5-10min, and then add the mixed solution to Matrigel During the process, stir while adding. After the addition, continue to stir until the mixture is evenly mixed to form the body of the antibacterial and healing-promoting hydrogel dressing. This process is completed in a sterile environment, and the temperature environment is 40°C-50°C.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation method and application of a novel medical antibacterial healing-promoting hydrogel dressing. The novel medical antibacterial healing-promoting hydrogel dressing comprises an antibacterial healing-promoting hydrogel dressing body and distilled water, and the antibacterial healing-promoting hydrogel dressing body is composed of distilled water, polyacrylamide, quaternized chitosan and matrigel. Matrigel and quaternized chitosan are adopted, the matrigel not only promotes formation of epithelization, vascularization and nervalization of a wound surface, but also can induce regeneration of skin appendages such as hair follicle sweat glands and the like and better recover tissue appearance and functions; the quaternized chitosan is a chitosan derivative with the strongest antibacterial effect and has broad-spectrum antibacterial activity; and a three-dimensional porous network structure of the polyacrylamide can provide a good microenvironment for migration and proliferation of repair cells, can inhibit rapid contraction of the wound surface and improve the repair effect, is good in mechanical strength, and can just make up the defect of poor mechanical strength of a natural polymer. Complementary advantages of the three components are achieved, and the repair effect of the wound surface is improved.

Description

technical field [0001] The invention relates to the technical field of wound repair, in particular to a preparation method and application of a novel medical antibacterial and healing-promoting hydrogel dressing. Background technique [0002] Wound repair has always been a common problem in orthopedics, plastic surgery, and hand surgery. There are many repair methods for skin and soft tissue wounds, including skin grafting, skin flaps, or skin stretch closure. In addition, tissue engineering methods to solve wound repair problems are becoming more and more It is becoming more and more extensive, and some repair effects can reach a very good level. The representative types include hydrogel, artificial dermis, acellular matrix, etc. The main purpose is to build a microenvironment conducive to wound repair and promote related wound repair. Repair the proliferation, migration and differentiation of cells, so as to achieve the purpose of closing the wound, but some synthesis meth...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0057A61L26/0066A61L26/008A61L26/0085A61L2300/232A61L2300/404A61L2300/412C08L5/08C08L33/26
Inventor 刘国辉薛航周武李卉米博斌刘毅刘静熊元胡良聪刘梦非
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap