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30 results about "Sacroiliac joint inflammation" patented technology
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siRNA for inhibiting ADAM17 (a disintegrin and metalloprotease 17) genes and application of siRNA
The invention discloses a siRNA for inhibiting ADAM17 (a disintegrin and metalloprotease 17) genes and an application of the siRNA. The invention discloses a chemically-modified dual-chain siRNA molecule, and particularly relates to a dual-chain siRNA molecule which is formed by chemically modifying and supplementing (as shown in (1) to (13)) at least one chain in the siRNA molecule indicated by A. The siRNA can be used as a treatment drug for arthritis and relevant inflammations, and the siRNA and preparations of the siRNA can be locally injected through a bone joint cavity to inhibit the inflammation factor expression so as to realize the treatment for the arthritis.
Owner:GUANGZHOU RIBOBIO +1
SiRNA (small interfering ribonucleic acid) composition inhibiting ADAMTS-5 (a disintegrin-like and metalloproteinase with thrombospondin type 1motifs-5) and ADAM17 (a disintegrin-like and metalloproteinase with thrombospondin type 1motifs 17) genes and application of siRNA composition
ActiveCN104560997AAchieve healingAntipyreticGenetic material ingredientsInflammatory factorsMolecular composition
The invention discloses an siRNA (small interfering ribonucleic acid) composition inhibiting an ADAMTS-5 (a disintegrin-like and metalloproteinase with thrombospondin type 1motifs-5) gene and an ADAM17 (a disintegrin-like and metalloproteinase with thrombospondin type 1motifs 17) gene and an application of the siRNA composition. The invention discloses the chemically modified double-chain siRNA molecular composition which comprises at least one of double-chain siRNA molecules as shown as (1) and at least one double-chain siRNA molecules as shown as (2). The siRNA composition can serve as a treatment medicine of arthritis and relevant inflammation, and the siRNA composition and a preparation of the siRNA composition can be injected locally through a bone articular cavity to inhibit inflammatory factor expression to achieve treatment of the joint inflammation.
Owner:ARGORNA PHARM CO LTD
siRNA for inhibiting gene ADAMTS-5 and application of siRNA
ActiveCN104560999AAchieve healingOrganic active ingredientsAntipyreticInflammatory factorsBones joints
The invention discloses siRNA for inhibiting a gene ADAMTS-5 and application of the siRNA. The invention discloses a chemically modified double-chain siRNA molecule which is formed in the way that any chemical modification from (1) to (13) in the Specification is performed on at least one of the chains in the siRNA molecule in A (in the Specification), and the complementation is performed. The siRNA disclosed by the invention can be used as a medicine for treating arthritis and related inflammations, and the siRNA and a preparation thereof can be injected into local parts of bone joint cavities to inhibit the expression of inflammatory factors and further realize treatment of joint inflammation.
Owner:ARGORNA PHARM LTD
Long non-coding RNA (lncRNA) and application thereof in diagnosis/treatment of rheumatoid arthritis (RA)
ActiveCN113278691APromote migrationPromote invasionOrganic active ingredientsAntipyreticJoints inflammationDiagnosis treatment
The invention discloses a long non-coding RNA (lncRNA) and application thereof in diagnosis / treatment of rheumatoid arthritis (RA). The lncRNA is lncRNA RP1-90J20.8. The invention relates to application of the lncRNA in evaluation of the severity of RA joint inflammation and joint damage and target drug therapy. A reagent for detecting the lncRNA RP1-90J20.8 can assist in RA diagnosis, evaluation and joint erosion damage judgment; and a target silent lncRNA RP1-90J20.8 gene can be used for inhibiting joint damage and assisting in treatment of RA. According to the invention, the biological function and clinical significance of the lncRNA RP1-90J20.8 in RA are clarified; a sufficient theoretical basis is provided for taking the lncRNA RP1-90J20.8 as a marker for auxiliary diagnosis of RA and prediction of RA prognosis and a new therapeutic target; and the lncRNA RP1-90J20.8 has great significance and application prospects in development of auxiliary diagnosis, prognosis evaluation and therapeutic drugs for RA.
Owner:SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
Application of cnidium lactone as [alpha]36 estrogen receptor activator
InactiveCN106880627AMild effectAvoid side effectsNervous disorderSkeletal disorderCnidium monnieriEstrogen receptor
The invention discloses an application of cnidium lactone as an [alpha]36 estrogen receptor activator, in particular an application of the cnidium lactone as the [alpha]36 estrogen receptor activator in preparing medicines or health care foods for preventing and treating osteoporosis, premature ovarian failure, climacteric syndrome, irregular menstruation, infertility, degenerative disc disease, bone joint inflammatory and immunological diseases, cardiovascular disease, alzheimer disease or bone metastases from cancer. The invention also discloses the [alpha]36 estrogen receptor activator, and cnidium lactone serves as an active ingredient of the [alpha]36 estrogen receptor activator at a concentration of 0.01-10 [mu]M.
![Application of cnidium lactone as [alpha]36 estrogen receptor activator](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/91ed82f9-aac4-40f6-8e7b-43f8c4c142e2/HDA0000878535210000011.png "Application of cnidium lactone as [alpha]36 estrogen receptor activator")
![Application of cnidium lactone as [alpha]36 estrogen receptor activator](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/91ed82f9-aac4-40f6-8e7b-43f8c4c142e2/HDA0000878535210000012.png "Application of cnidium lactone as [alpha]36 estrogen receptor activator")
![Application of cnidium lactone as [alpha]36 estrogen receptor activator](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/91ed82f9-aac4-40f6-8e7b-43f8c4c142e2/HDA0000878535210000021.png "Application of cnidium lactone as [alpha]36 estrogen receptor activator")
Owner:LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
Biological agent for preventing and relieving joint sub-health and preparation method thereof
InactiveCN113332405AIncrease painRelieve painHydroxy compound active ingredientsAntipyreticSodium hyaluronateProteoglycan
The invention discloses a biological agent for preventing and relieving joint sub-health and a preparation method thereof, and belongs to the technical field of biological agents. The biological agent of the present invention contains a plurality of bioactive components and a plurality of active ingredients of Chinese herbs. The bioactive components comprise S-adenosylmethionine, sodium hyaluronate, sodium chondroitin sulfate, vitrin and acetyl glucosamine, can prevent decomposition of proteoglycan by enzyme, provide exogenous hyaluronic acid for human joints, activate synthesis of mucopolysaccharide in the body, and promote synthesis of hyaluronic acid and collagen and cartilage regeneration. The bioactive components can improve content of hyaluronic acid in the body, reduce cartilage loss and maintain morphology of cartilage and synovial fluid. The active ingredients of Chinese herbs comprise fructus liquidambaris extract, herba lycopodii extract, fructus morinda citrifolia and ginger root extract, and have the effects of relaxing tendons and activating collaterals, promoting blood circulation to remove blood stasis, improving local microcirculation and relieving pain. According to the biological agent, Chinese medicines and western medicines are combined to fundamentally prevent and relieve joint inflammation.
Owner:东莞市容大生物科技有限公司
Compound preparation for treating rheumatoid arthritis and preparation method of compound preparation
InactiveCN106902207AReduce erosionReduce the numberAnthropod material medical ingredientsAntipyreticInflammatory infiltrationAnkle
The invention relates to a compound preparation for treating rheumatoid arthritis. The compound preparation is prepared from the following crude drugs in parts by weight: 5 to 12 parts of fried fructus arctii, 4 to 11 parts of bombyx batryticatus, 8 to 15 parts of radix notoginseng, 4 to 12 parts of radix angelicae pubescentis, 3 to 9 parts of radix gentianae macrophyllae, and 4 to 12 parts of rhizoma pinelliae. The animal experiment shows that the compound preparation can reduce an inflammatory infiltration area, bony defects and articular cartilage defects of TNF-Tg rheumatoid arthritis mice, can promote lymphatic return and can alleviate ankle joint inflammatory injury. The traditional Chinese medicine compound preparation can improve the rheumatoid arthritis symptom, and can avoid the inconvenience caused by the temporary decoction of the traditional Chinese herbal decoction before the administration and the likeliness in mildew; and in addition, the invention also provides a preparation method of the compound preparation.
Owner:LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for joint stability
PendingUS20210077439A1Decreasing joint instabilityReduce instabilityPeptide/protein ingredientsMuscular disorderJoint damagePhysiology
The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to decrease joint instability, increase joint stability, decrease joint stiffness, improve joint function, improve joint health, improve balanced movement and improve skeletal joint stability during muscle movement. HMB is administered to increase muscle strength and / or muscle mass in a side of the body contralateral to joint inflammation, joint damage, and / or joint injury.
Owner:METABOLIC TECH
Application of LCA in preparation of drug for treating joint inflammation or cartilago articularis and bone destruction
The invention relates to an application of LCA (9, 9'-O-bi-(E)-feruloylated-meso-5, 5'-dimethoxy secoisolariciresinol) in preparation of drug for treating arthritis or cartilago articularis and bone destruction. By using a cell heat transfer technology, the compound LCA can be combined with MEK1 protein and cathepsinK protein in cells, animal tests verify that the LCA can improve the symptoms of a rat with rheumatoid arthritis and the research results show that LCA has a double target effects of simultaneously inhibiting immune inflammation and preventing and treating bone destruction and has a board application prospect in clinical treatment of diseases such as rheumatoid arthritis, osteoarthritis, osteoporosis and the like.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Composite hyaluronic acid composition for preventing and relieving joint diseases
The invention discloses a composite hyaluronic acid composition for preventing and relieving joint diseases, and belongs to the technical field of osteoarthritis health care products. Comprising hyaluronic acid, Anbenefit milk polypeptide, collagen peptide, chitosan oligosaccharide, chondroitin sulfate, glucosamine, vitamin D3, calcium carbonate, donkey-hide gelatin, ginseng peptide powder, licorice powder, curcumin, a plant extract, magnesium sulfate, manganese sulfate and zinc sulfate. The composite hyaluronic acid composition disclosed by the invention can be used for solving arthralgia, solving the problem of joint inflammation from the perspective of tonifying both inside and outside, promoting absorption of nutrient substances by joints, supplementing precursor substances of articular cartilage and synovial fluid, improving the overall health level, stimulating the repair capability of a human body, promoting absorption of nutrients and reducing pain.
Owner:SHANDONG FOCUSFREDA BIOTECH CO LTD
Application of pericarpium citri reticulatae essential oil to preparation of products for preventing or treating arthritis
The invention provides an application of pericarpium citri reticulatae essential oil to preparation of products for preventing or treating arthritis. Research results show that a pericarpium citri reticulatae essential oil component can relieve CFA-induced rheumatoid arthritis of rats and can effectively relieve joint tissue damage caused by CFA; and the pericarpium citri reticulatae essential oilcan inhibit the lesion degree of arthritis by inhibiting activity expression of tumor necrosis factors TNF-alpha and COX-2, and control the joint arthritis reaction, so that the pain of a patient caused by the arthritis is relieved to the greatest extent, and a new choice is provided for developing novel anti-arthritis medicines.
Owner:GUANGDONG UNIV OF TECH
Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for joint stability
The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to decrease joint instability, increase joint stability,decrease joint stiffness, improve joint function, improve joint health, improve balanced movement and improve skeletal joint stability during muscle movement. HMB is administered to increase muscle strength and / or muscle mass in a side of the body contralateral to joint inflammation, joint damage, and / or joint injury.
Owner:METABOLIC TECH
A kind of external plaster for treating joint pain and arthritis and preparation method thereof
ActiveCN107412432BImprove breathabilityGood slow releaseHydroxy compound active ingredientsAntipyreticJoints inflammationLanolin
Owner:杭州仁德药业股份有限公司
siRNA composition and application thereof for suppressing adamts-5 and adam17 genes
ActiveCN104560997BAchieve healingAntipyreticGenetic material ingredientsInflammatory factorsMolecular composition
The invention discloses an siRNA (small interfering ribonucleic acid) composition inhibiting an ADAMTS-5 (a disintegrin-like and metalloproteinase with thrombospondin type 1motifs-5) gene and an ADAM17 (a disintegrin-like and metalloproteinase with thrombospondin type 1motifs 17) gene and an application of the siRNA composition. The invention discloses the chemically modified double-chain siRNA molecular composition which comprises at least one of double-chain siRNA molecules as shown as (1) and at least one double-chain siRNA molecules as shown as (2). The siRNA composition can serve as a treatment medicine of arthritis and relevant inflammation, and the siRNA composition and a preparation of the siRNA composition can be injected locally through a bone articular cavity to inhibit inflammatory factor expression to achieve treatment of the joint inflammation.
Owner:ARGORNA PHARM CO LTD
Medicine for treating femoral head necrosis and preparation method of medicine
InactiveCN105596918AEffective treatment of necrosisDispersion deliveryAnthropod material medical ingredientsJoints inflammationGenus Agkistrodon
Femoral head necrosis is a pathologic evolution process and firstly happens in a bearing area of a femoral head, under the action of stress, a necrosis bone trabecula structure can be damaged, that is, microscopy bone fracture, the following reparative process is not complete, and the process of damage-repairing is continued, so that the femoral head structure is changed, the femoral head is collapsed and deformed, and joint inflammation can be caused. Pain, joint action obstacle and loaded walking dysfunction can be caused by femoral head. The medicine is prepared from medicines including silkworm excrement, herba lycopi, kadsura pepper stems, gadfly, homalomena occulta, leech, erythrina indica lam, philippine flemingia roots, agkistrodon, kadsura coccinea, tiger-bone, folium photiniae, cortex acanthopanacis, turtle shells, taxillus sutchuenensis, morinda officinalis, mulberry twig, epimedium brevicornu, paniculate swallowwort roots, teasel roots, Chinese starjasmine stems, English walnut seeds, pawpaw, cistanche, eupatorium, atractylodes macrocephala, rhizoma atractylodis, hyacinth beans, inula flower, caulis spatholobi, pig bile, leonurus, rhizoma sparganii, salvia miltiorrhiza and polygonum cuspidatum. Due to the effects of the combined medicines, a synergistic effect can be achieved, and thus femoral head necrosis can be effectively treated.
Owner:薛学明
Sulfonamide compound for treating gout or hyperuricemia and preparation method thereof
A compound as represented by formula (I), and optical isomers, solvates, pharmaceutically-acceptable salts, or prodrugs thereof. The present invention has urate transporter 1 (URAT1) inhibitory activity, can be used for treatment of gout and hyperuricemia, and can also be used for treatment of diseases related to abnormal URAT1 activity, such as recurrent gout attacks, gouty arthritis, hypertension, cardiovascular diseases, coronary heart disease, Lesch-Nyhan syndrome, Kearns-Sayre syndrome, kidney diseases, kidney stones, kidney failure, joint inflammations, arthritis, urolithiasis, lead poisoning, hyperparathyroidism, psoriasis, sarcoidosis, or hypoxanthine-guanine phosphoribosyltransferase deficiency. (I)
Owner:HINOVA PHARM INC
Pyrazole-containing betulinic acid derivative as well as preparation method and application thereof
PendingCN114805469ANovel structureOrganic active ingredientsAntipyreticPainful jointsInflammatory factors
The invention relates to betulinic acid derivatives containing pyrazole and a preparation method and application of the betulinic acid derivatives, in particular to compounds with the structure shown in the general formula I. Definitions of all groups are shown in the specification. A rat arthritis model is induced through sodium iodoacetate, and the change of the degree of arthralgia is observed; an in-vitro induced differentiation system is adopted, and the osteoclast differentiation and inflammatory factor generation level of the osteoclast precursor is observed. Results show that the compound adopted by the invention has inhibitory activity on osteoclast differentiation and inflammatory factor generation, has a good treatment effect on osteoarthritis and joint inflammation diseases with bone destruction, bone erosion and synovitis as pathological characteristics, and has an ideal clinical application prospect.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Application of lca in preparation of medicine for treating joint inflammation or articular cartilage and bone destruction
ActiveCN104434900BSymptoms improvedPrevent vandalismOrganic active ingredientsAntipyreticDiseaseJoints inflammation
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Preparation method and application of opg-hsp70 fusion protein
InactiveCN101434656BInhibition of bone destructionInhibit inflammationPeptide/protein ingredientsSkeletal disorderJoints inflammationA-DNA
The invention is a "preparation method and application of OPG-HSP70 fusion protein", which belongs to the field of biomedical new technology. The invention provides an osteoprotegerin-heat shock protein 70 (OPG-HSP70) fusion protein drug. The drug targets synovitis, the most important pathological feature of rheumatoid arthritis (RA), accompanied by destruction of cartilage and bone. Through osteoprotegerin (OPG) as a decoy receptor, it can interact with cells expressed by osteoblasts and other cells. Receptor Activator of Nuclear Factor κB Ligand (RANKL) binds, blocks the binding of RANKL to RANK expressed by osteoclasts, thereby inhibiting bone resorption involving osteoclasts; uses the protective polypeptide fragment of heat shock protein (HSP) to inhibit joint inflammation. The invention includes the DNA sequence encoding the fusion protein; the method of producing the fusion protein through recombinant technology; and the biological activity of the fusion protein, etc.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Application of artesunate in treating rheumatoid arthritis model rats
PendingCN114831982AEffective treatmentRelieve swellingOrganic active ingredientsSkeletal disorderJoints inflammationPharmacology
The invention relates to the technical field of medicine, in particular to application of artesunate in treating rheumatoid arthritis model rats. The invention discloses a possible molecular mechanism of artesunate for relieving joint inflammation of a rheumatoid arthritis model rat, and discovers that artesunate can effectively relieve joint swelling and arthritis index of the model rat and improve osteoporosis. The artesunate has the advantages of safety, low price, small side effect and the like, is expected to overcome the problems of poor clinical curative effect, high price, multiple complications and the like of the existing medicine for treating rheumatoid arthritis, and becomes a brand new medicine for treating systemic lupus erythematosus.
Owner:莫汉有
Expression cassette of interleukin-1 receptor antagonist protein and AAV-based gene delivery system
The invention relates to a nucleic acid molecule for coding interleukin-1 receptor antagonist protein, a transgenic expression cassette containing the nucleic acid molecule, a gene delivery system containing the transgenic expression cassette and application of the gene delivery system. The transgene expression cassette and the gene delivery system can be used for treating various diseases, including malignant tumors and inflammatory diseases, such as joint inflammation, especially osteoarthritis, which can be improved by blocking an IL-1 signal channel.
Owner:SHANGHAI MYGT BIOPHARMACEUTICAL LLC
Compositions
ActiveCN110139658ANo damage percentageHigh yieldHydroxy compound active ingredientsAntipyreticJoints inflammationRubus sachalinensis
The present invention relates to an extract obtained from or obtainable from Rubus idaeus, a composition comprising an extract obtained from or obtainable from Rubus idaeus, processes for providing such an extract, and methods and uses relating to such extracts. In particular, the present invention relates to an extract or composition for use in treating or preventing inflammation, such as arthritis and joint inflammation.
Owner:NATUREX INC
Application of menthone to preparation of medicine for treating rheumatoid arthritis
PendingCN112755010ARelief of local symptoms in miceRelieve local symptomsPowder deliveryOrganic active ingredientsInflammatory factorsJoints inflammation
The invention relates to the technical field of medicines, and discloses an application of menthone to preparation of a medicine for treating rheumatoid arthritis. A collagen-induced rheumatoid arthritis mouse model (CIA) proves that the menthone can effectively relieve the rheumatoid arthritis symptom by down-regulating the inflammatory factor level in a joint inflammation part and blood cells and regulating different subtype T cells to be in balance, and has a good anti-rheumatoid arthritis effect. The menthone can be used for preparing the medicine for treating the rheumatoid arthritis, and a new direction is provided for seeking the safe and effective medicine for resisting the rheumatoid arthritis.
Owner:SUZHOU UNIV
Visco-supplement compositions, and methods of use thereof
ActiveUS10765705B2Pharmaceutical delivery mechanismMammal material medical ingredientsJoints inflammationTranscellular fluid
Owner:LIVENTA BIOSCI
Application of foxd1 in preparation of products for treating and/or preventing animal osteoarthritis
ActiveCN108607103BAccelerated agingAnti agingPeptide/protein ingredientsAntipyreticDiseaseEctomesenchyme
Owner:INST OF ZOOLOGY CHINESE ACAD OF SCI
Application of tangerine peel essential oil in preparation of products for preventing or treating arthritis
The invention provides the application of tangerine peel essential oil in the preparation of products for preventing or treating arthritis. The research results of the present invention show that the composition of tangerine peel essential oil can alleviate the rat rheumatoid arthritis induced by CFA, and can effectively alleviate the joint tissue damage caused by CFA. The tangerine peel essential oil can inhibit the active expression of tumor necrosis factor TNF-α and COX-2 Thereby inhibiting the lesion degree of arthritis, controlling the joint inflammatory response, thereby relieving the pain caused by arthritis to the greatest extent, and providing a new option for the development of new anti-arthritis drugs.
Owner:GUANGDONG UNIV OF TECH
A traditional Chinese medicine composition for treating gouty arthritis and its preparation method and application
InactiveCN110201073BImprove joint swellingImprove joint inflammation indexSkeletal disorderPteridophyta/filicophyta medical ingredientsJoints inflammationTurpentine
The invention discloses a traditional Chinese medicine composition for treating gouty arthritis and its preparation method and application. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 5-8 parts by weight of heather leaves, 10-parts by weight of pine knots 15 parts by weight, 20-25 parts by weight of cloth dregs leaves, 20-25 parts by weight of Hydrangea japonica, 6-9 parts by weight of Herba Sinensis, 5-8 parts by weight of Agaricus officinalis root, 5-7 parts by weight of Sorrel, 5 thousand years of health -8 parts by weight. The traditional Chinese medicine composition has the effects of dispelling wind and clearing heat, dehumidifying and relieving pain, regulating qi and dredging collaterals. The results of animal experiments show that the traditional Chinese medicine composition can improve the degree of joint swelling and joint inflammation index of the toes of mice with gouty arthritis, and can also improve the index of immune organs and organs and antioxidant capacity of mice with gouty arthritis, and No side effects. The proposal of the invention provides a new technical means for treating gouty arthritis.
Owner:XINYU UNIV
A small molecular compound for treating rheumatoid arthritis and its use
ActiveCN109096360BArthritis Symptom Score ReductionScoring reliefSkeletal disorderSteroidsPharmaceutical SubstancesInflammatory infiltration
The invention relates to a small molecular compound for treating rheumatoid arthritis, the active ingredient of which is papaya saponin I, and the concentration is 0.1-10 μM. The present invention has been proved by animal experiments that papaya saponin I can reduce joint damage and inflammatory infiltration area, bone mass defect and cartilage defect in mice with collagen-induced rheumatoid arthritis, reduce ankle joint inflammation damage, and can improve rheumatoid joints inflammation symptoms. The invention also discloses the application of the papaya saponin I in the preparation of rheumatoid arthritis medicine or health care product.
Owner:LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
Traditional Chinese medicine composition for treating female gouty arthritis as well as preparation method and application of traditional Chinese medicine composition
ActiveCN114272343AImprove joint inflammation indexImprove the content of inflammatory mediatorsAnthropod material medical ingredientsAntipyreticJoints inflammationReceptor
The invention discloses a traditional Chinese medicine composition for treating female gouty arthritis as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 4-5 parts of aspongopus, 6-7 parts of fenugreek, 6-7 parts of radix echinopsis, 10-15 parts of commelina communis, 0.1-1 part of resina toxicodendri and 4-5 parts of amomum tsao-ko. The traditional Chinese medicine composition has the basic effects of warming kidney and expelling dampness, removing heat and diminishing swelling, and removing blood stasis and resolving stagnation. Experiments prove that the traditional Chinese medicine composition can improve the joint swelling degree, the joint inflammation index and the related inflammatory mediator content of the toe of a female gouty arthritis model mouse, and can also improve the Toll-like receptor-4 protein and gene basic expression level of the toe of the model mouse; the traditional Chinese medicine composition has no influence on visceral organ indexes and body weight of important organs of a model mouse, so that the traditional Chinese medicine composition disclosed by the invention is effective for treating the female gouty arthritis and has no side effect.
Owner:黑龙江儒泰科技发展有限责任公司
Collagen hydrolysates as a beneficial prebiotic and their effect on joint inflammation and osteoarthritis
ActiveUS11110147B2Improving gut microbiomePromote health health healthOrganic active ingredientsHydrolysed protein ingredientsJoints inflammationPharmaceutical Substances
The invention generally relates to pharmaceuticals and / or nutraceuticals. More particularly, the invention provides compositions of collagen-based peptides and specific digestive tract microbes useful for supporting or promoting joint, skin and / or bone health, and methods of preparation and use thereof. The invention further provides for the use of compositions of collagen-based peptides as a prebiotic for modulating the gut microbiome.
Owner:ROUSSELOT BV +1
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