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Long non-coding RNA (lncRNA) and application thereof in diagnosis/treatment of rheumatoid arthritis (RA)

A rheumatoid and arthritis technology, applied in the direction of DNA/RNA fragments, non-central analgesics, recombinant DNA technology, etc., can solve the problems of insufficient research on the role of lncRNA, achieve the effect of promoting migration and invasion, and have great application prospects

Active Publication Date: 2021-08-20
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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Problems solved by technology

At present, there is insufficient research on the role of lncRNA in the biological function of RA-FLS

Method used

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  • Long non-coding RNA (lncRNA) and application thereof in diagnosis/treatment of rheumatoid arthritis (RA)
  • Long non-coding RNA (lncRNA) and application thereof in diagnosis/treatment of rheumatoid arthritis (RA)
  • Long non-coding RNA (lncRNA) and application thereof in diagnosis/treatment of rheumatoid arthritis (RA)

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Embodiment 1

[0049] 1. Experimental process and methods

[0050] The present invention screens highly expressed lncRNA in RA-FLS through high-throughput expression profile chip, and further discovers lncRNA RP1-90J20.8 related to RA joint destruction for the first time through clinical analysis.

[0051] Specifically, we used the Arraystar Human lncRNA chip to detect differentially expressed lncRNAs in the synovial FLS (n=5) of RA patients (n=5) and normal control patients, and the results showed that lncRNA RP1-90J20 in RA-FLS. 8 expression was 11.84 times higher than that of synovial FLS in normal control patients, indicating that lncRNA RP1-90J20.8 plays an important role in the development of RA and can be a molecular target for diagnosis, disease assessment and treatment.

[0052] We further expanded the sample size and used qPCR to detect the expression difference of lncRNA RP1-90J20.8 in 20 cases of RA-FLS and 11 cases of Orth. The expression of lncRNA RP1-90J20.8 plays an importan...

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Abstract

The invention discloses a long non-coding RNA (lncRNA) and application thereof in diagnosis / treatment of rheumatoid arthritis (RA). The lncRNA is lncRNA RP1-90J20.8. The invention relates to application of the lncRNA in evaluation of the severity of RA joint inflammation and joint damage and target drug therapy. A reagent for detecting the lncRNA RP1-90J20.8 can assist in RA diagnosis, evaluation and joint erosion damage judgment; and a target silent lncRNA RP1-90J20.8 gene can be used for inhibiting joint damage and assisting in treatment of RA. According to the invention, the biological function and clinical significance of the lncRNA RP1-90J20.8 in RA are clarified; a sufficient theoretical basis is provided for taking the lncRNA RP1-90J20.8 as a marker for auxiliary diagnosis of RA and prediction of RA prognosis and a new therapeutic target; and the lncRNA RP1-90J20.8 has great significance and application prospects in development of auxiliary diagnosis, prognosis evaluation and therapeutic drugs for RA.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to a long non-coding RNA and its application in diagnosis / treatment of rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by progressive joint destruction. Its main pathological manifestations are synovitis and pannus formation, which in turn lead to the destruction of articular cartilage and bone, and finally joint deformity. and loss of function. Epidemiological surveys show that the global incidence of RA is 0.5%-1%. The latest RA diagnosis and treatment guidelines in my country point out that the incidence in mainland China is 0.42%, and the total affected population is about 5 million. The low awareness of RA and non-standard treatment lead to the high disability rate of RA, and the incidence of disability gradually increases with the prolongation of the disease course, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/113A61K45/00A61K31/7105A61P19/02A61P29/00
CPCC12Q1/6883A61K45/00A61K31/7105A61P19/02A61P29/00C12Q2600/178C12Q2600/158
Inventor 戴冽马剑达荆俊吴滔
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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