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Application of artesunate in treating rheumatoid arthritis model rats

An arthritis model and artesunate technology, applied in the medical field, can solve problems such as adverse reactions, high price, and difficulty in popularization, and achieve the effects of relieving joint swelling, reducing arthritis index, and good controllability

Pending Publication Date: 2022-08-02
莫汉有
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the drug treatment of RA mainly consists of non-steroidal anti-inflammatory drugs (NSAIDs), anti-rheumatic drugs (DMARDs) and glucocorticoids, but these drugs cannot control the activity and development of RA, and there will be obvious adverse reactions after long-term use , the treatment effect of biological agents is relatively satisfactory, but the current price is expensive, and it is difficult to popularize

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  • Application of artesunate in treating rheumatoid arthritis model rats
  • Application of artesunate in treating rheumatoid arthritis model rats
  • Application of artesunate in treating rheumatoid arthritis model rats

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Embodiment Construction

[0017] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0018] In the embodiment of the present invention, the artesunate injection is produced by Guilin South Pharmaceutical Co., Ltd., with the Chinese medicine approval word H10930195, the trade name is Artesun, and the English trade name is Artesunate for injection.

[0019] The arthritic rat (CIA) model is easily and reliably prepared by intradermal injection of bovine type II collagen and the same amount of Freund's adjuvant. It is the most commonly used experimental animal model for the study of RA applications. The CIA model can better simulate the joints of RA. Pathological changes, and its chronic pathological process is not self-limiting, it is the most ideal animal model to study RA. Therefore, 200 micrograms of bovine type II collagen: Freund's complete adjuvant (1:1) was injected intradermally at the root of the tail. After 7 days, the same amount ...

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Abstract

The invention relates to the technical field of medicine, in particular to application of artesunate in treating rheumatoid arthritis model rats. The invention discloses a possible molecular mechanism of artesunate for relieving joint inflammation of a rheumatoid arthritis model rat, and discovers that artesunate can effectively relieve joint swelling and arthritis index of the model rat and improve osteoporosis. The artesunate has the advantages of safety, low price, small side effect and the like, is expected to overcome the problems of poor clinical curative effect, high price, multiple complications and the like of the existing medicine for treating rheumatoid arthritis, and becomes a brand new medicine for treating systemic lupus erythematosus.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to the application of artesunate in the treatment of rheumatoid arthritis model rats. Background technique [0002] Rheumatoid arthritis (RA) is an immune connective tissue disease with a high incidence, mainly manifested as progressive inflammation of the affected joints, chronic infiltration of a large number of inflammatory cells in the synovial tissue of the joints as its main pathological changes, chronic inflammation and Abnormal activation of osteoclasts eventually leads to the destruction of cartilage and bone tissue, and ultimately leads to deformity and dysfunction of the affected joints. [0003] The main animal models to study rheumatoid arthritis are collagen-induced arthritis (CIA) model and adjuvant-induced arthritis (AA) model. Freund first invented the adjuvant-induced arthritis (AA) model in the 1950s. Trentham successfully used bovine type II collagen and the sa...

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Application Information

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IPC IPC(8): A61K31/357A61P19/02A61P37/02
CPCA61K31/357A61P19/02A61P37/02Y02A50/30
Inventor 莫汉有朱浈臻韦思如林东
Owner 莫汉有
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