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46 results about "Oxyhemoglobins" patented technology

A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.

Non-invasive blood component measurement system

Non-invasive, optical apparatus and methods for the direct measurement of hemoglobin derivatives and other analyte concentration levels in blood using diffuse reflection and transmission spectroscopy in the wavelength region 400-1350 nm which includes the transparent tissue window from approximately 610 to 1311 nanometers and, using diffuse reflection spectroscopy, the mid-infrared region from 4.3-12 microns in wavelength. Large area light collection techniques are utilized to provide a much larger pulsate signal than can be obtain with current sensor technology. Sensors used in separate or simultaneous precision measurements of both diffuse reflection and transmission, either separately or simultaneously, from pulsate, blood-perfused tissue for the subsequent determination of the blood analytes concentrations such as arterial blood oxygen saturation (SaO2), carboxyhemoglobin (COHb), oxyhemoglobin (OHb), deoxyhemoglobin (dOHb), methemoglobin (metHb), water (H2O), hematocrit (HCT), glucose, cholesterol and proteins such as albumin and other analytes components.
Owner:3WAVE OPTICS

Multi-Wavelength Spatial Domain Near Infrared Oximeter to Detect Cerebral Hypoxia-Ischemia

Methods and apparatus for measuring cerebral O2 saturation and detecting cerebral hypoxia-ischemia using multi-wavelength near infrared spectroscopy (NIRS). Near-infrared light produced by an emitter is directed through brain tissue. The intensity of the light that passes through the brain tissue is measured using photodiode detectors positioned at distinct distances from the emitter. This process is conducted for at least three wavelengths of near-infrared light. One of the wavelengths used is substantially at an isobestic point for oxy-hemoglobin and deoxy-hemoglobin, but the other two may be any wavelengths within the near-infrared spectrum (700 nm to 900 nm), so long as one of the additional wavelengths is greater than the isobestic point and the other is less than the isobestic point. Tissue oxygenation is calculated using an algorithm derived from the Beer-Lambert law. Cerebral hypoxia-ischemia may be diagnosed using the calculated tissue oxygenation value.
Owner:KURTH CHARLES DEAN

Method of measuring the stress or relaxation level of a mammal

A method of measuring the stress or relaxation level of a mammal and a method of measuring the activity of the sympathetic nervous system of a mammal by measuring quantititative levels of deoxyhemoglobin and oxyhemoglobin are disclosed. Preferably, the levels of deoxyhemoglobin and hemoglobin are measured by a noninvasive technique, such as spectroscopy. A method of changing the activity of the sympathetic nervous system of a mammal is also disclosed, wherein the method includes a step of administering an effective amount of sensory regimen to the mammal. The method is useful for humans who are operating vehicles or machinery, who are suffering from cardiovascular disease or related complications, who are pregnant, or who are preparing for sleep. In addition, a method of improving the complexion of the skin of a mammal is disclosed.
Owner:JOHNSON & JOHNSON CONSUMER COPANIES

Oxygen-carrying enhanced photodynamic photosensitive liposome and preparation and application thereof

The invention provides a photosensitive liposome carrying oxygen to enhance photodynamics, which is composed of phospholipids, cholesterol, long-circulation materials, hemoglobin, and chemotherapeutic drugs and / or photosensitizers, each component is dissolved in an organic solvent, and the Steam to form a thin film, then add oxyhemoglobin solution, or a mixed solution of photosensitizers and / or chemotherapeutic drugs and oxyhemoglobin, and hydrate to obtain a multilayer liposome solution, which is obtained by ultrasonication and purification. The liposome of the present invention can simultaneously carry oxygen, chemotherapeutic drugs and / or photosensitizers to the tumor site, alleviate the hypoxic state of tumor cells, improve the sensitivity of tumor cells to chemotherapeutic drugs, inhibit tumor growth and metastasis, and can also Under the irradiation of near-infrared light, the photosensitizer in the liposome generates more singlet oxygen, resulting in an enhanced photodynamic therapy effect. The loaded drug molecules are released to realize remote control of drug release.
Owner:ZHEJIANG UNIV

Method for demonstrating pre-emergent pimples

ActiveUS20070237374A1Preventing and minimizing emergencePrevent and minimize emergenceDiagnostics using lightCharacter and pattern recognitionPimpleOxy hemoglobin
A method for demonstrating pre-emergent pimples is disclosed. The method includes providing a camera having a 25 mm macro lens and a linear polarizing filter including from 10 to 50 narrow band filters in the spectral range of 400-970 nm, and a light source having a linear polarizer oriented vertical to a polarization plane of the camera polarizer; taking a sequence of images of the face of a subject with the camera; creating an erythema map of the imaged area using oxy-hemoglobin values at each corresponding pixel; taking a visible-light image of the face of the subject; and comparing the images to see pre-emergent pimples. The method enables consumers to see pre-emergent pimples and treat them, which results in preventing the pimples from emerging or reducing the emergence of the pimples.
Owner:JOHNSON & JOHNSON CONSUMER COPANIES

Near infrared photonic prostatoscopy analyzer

A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers / light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.
Owner:ALFANO ROBERT R +6

Endoscope system and motion control method thereof, and processor device

The invention provides an endoscope system and a motion control method thereof, and a processor device; therefore, even if the difference of oxygen states of blood vessels is very small, the difference can be identified to be color difference being displayed; a test body is illuminated by narrow band light of a first different absorb waveband with oxyhemoglobin having a bigger light absorption factor than reduced hemoglobin having a smaller light absorption factor, and the test body is videoed to obtain blue image data Bx. The test body, illuminated by G light having green waveband, is videoed to obtain green image data Gy; intensity ratio B / G is calculated according to the blue image data Bx and the green image data Gy; the intensity ratio B / G and the reduction of the oxygen saturation correspondingly enlarges; gain processing corresponding to the intensity ratio B / G is carried out for the blue image data Bx and the green image data Gy, thereby obtaining blue image data Bx* and green image data Gy*. And oxygen saturation image can be displayed according to the blue image data Bx* and green image data Gy*.
Owner:FUJIFILM CORP

Non-invasive monitoring method and device for cerebral blood oxygen

The invention discloses a non-invasive monitoring method and a monitoring device for cerebral blood oxygen, and develops a non-invasive monitoring method for blood oxygen saturation of local tissues of a human brain by utilizing different absorbances of oxyhemoglobin and deoxidized hemoglobin to near-infrared light, so that the method does not cause harm to a human body; continuous real-time monitoring of the cerebral blood oxygen value can be achieved through a continuous cerebral blood oxygen value prediction model, the influence of melanin is considered, correction factors are added, surface interference signals and deep useful signals are detected respectively, the content of the collected signals is richer, and the cerebral blood oxygen signals with the high signal-to-noise ratio canbe obtained through processing conveniently; further, the cerebral forehead lobe area local oxyhemoglobin saturation monitoring value without the human head tissue interference signal is solved, so that the cerebral oxyhemoglobin continuous monitoring stability is better, and the monitoring precision is higher. A new solution is provided for non-invasive monitoring of cerebral blood oxygen, and clinical application of non-invasive monitoring of cerebral blood oxygen can be better promoted.
Owner:CHONGQING UNIV

Alzheimer's disease auxiliary diagnosis system based on fNIRS and graph neural network

The invention discloses an Alzheimer's disease auxiliary diagnosis system based on fNIRS and a graph neural network. The auxiliary diagnosis system is used by the following steps: an electroencephalogram detection module is used to perform multi-channel detection on oxyhemoglobin, deoxidized hemoglobin and total hemoglobin when brains of an AD patient and a normal person are in an active state byusing a functional near-infrared spectral imaging device, and an fNIRS data set is constructed; an adjacency matrix construction module is used to constructs an adjacency matrix for the fNIRS data setby using correlation between channels; a node feature matrix construction module is used to perform feature extraction on the fNIRS data set to construct a node feature matrix; a graph structure construction module is used to respectively construct an AD patient graph structure and a normal person graph structure according to the adjacent matrix and the node feature matrix to form a training dataset; and an Alzheimer's disease recognition module is used to train a constructed graph neural network by using the training data set, recognize the test data set of the to-be-tested person by usingthe trained graph neural network, and output an auxiliary diagnosis result. The graph neural network is applied to classification of the fNIRS data.
Owner:SHANDONG UNIV

Functional magnetic resonance imaging using steady state free precession

A method for functional magnetic resonance imaging (fMRI) uses steady-state free precession (SSFP) to image changes in blood oxygenation between two time periods. A center frequency of the SSFP sequence is placed between the different resonant frequencies for oxyhemoglobin and deoxyhemoglobin whereby the signals have a phase difference of 180° and tend to cancel. By repeating the SSFP imaging sequence at different times, the difference in the measured signals provides a measure of change in oxyhemoglobin. RF flip angle of the SSFP sequence is chosen to maximize signal level in the frequency range from that of water in the presence of oxyhemoglobin and that of water in the presence of deoxyhemoglobin.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Mammary gland blood oxygen function imaging method and system

InactiveCN1810210ARealize synchronous photo takingImage data sufficientImage data processing detailsRadiation diagnosticsDigital signal processingComputer image
Mammary gland blood oxygen function imaging method and system is disclosed. The method includes irradiating mammary gland tissue with a double wavelength light source, receiving light with a detector, converting the analog signal of light strength into digital signal, performing image processing to calculate the variation in oxyhemoglobin and deoxyhemoglobin, and final mapping the the variation in oxyhemoglobin and deoxyhemoglobin to form figure. The system features its double wavelength generator connected to the light source controlling module, and its image analysis and processing system connected to the computerized central processing system. Using the imaging method and system can obtain sufficient and accurate image data for post computer image treatment and obtain raised diagnosis coincidence rate.
Owner:深圳市国基科技有限公司

Apparatus for simultaneously acquiring multiple images of biological tissues and method thereof

PendingCN110338814ARealize multi-parameter monitoringRealize full-frame image acquisitionDiagnostics using lightSensorsLaser lightImaging lens
The invention relates to an apparatus for simultaneously acquiring multiple images of biological tissues and a method thereof. The apparatus comprises a light source mechanism and an optical imaging mechanism; the light source mechanism comprises a laser light source and a first incoherent visible light source and a second incoherent visible light source having significantly different molar absorption coefficients of oxyhemoglobin and deoxyhemoglobin; the optical imaging mechanism includes an imaging lens group, a filter switcher, and an optoelectronic imaging device disposed in sequence alonga light detecting path, and a visible light filter and a laser filter are embedded in a optical filter switching device to form a visible light filter channel and a laser filter channel. The apparatus can simultaneously acquire multiple images of biological tissues, pixel-level registration can be performed between different parameter images, so that the precise fusion of hemodynamic multi-parameter detection can be achieved, the full-frame image acquisition can be achieved, the reduction of the resolution of an imaging space is not required, and the spectra between different types of imagesdo not interfere with each other.
Owner:武汉迅微光电技术有限公司

Near-infrared brain imaging spectrum recognition method

ActiveCN113180650AReduce the influence of subjective consciousnessDiagnostic recording/measuringSensorsPattern recognitionImaging brain
The invention discloses a near-infrared brain imaging spectrum analysis method, which comprises the following steps of: extracting single-channel full-time-sequence spectrum data of relative concentrations of deoxyhemoglobin and oxyhemoglobin of a plurality of channels in a forehead calibration brain region of a patient under the stimulation of a cognitive task, constructing a detection curve of deoxyhemoglobin and oxyhemoglobin according to the spectrum data; sampling the detection curve, conducting zoning sampling with the total detection time T as the horizontal axis, and conducting normalization processing on the longitudinal axis, so as to obtain a final data set; and constructing a neural network algorithm model according to the standard map curve, respectively inputting the final data sets of the plurality of channels into the neural network algorithm model, judging the proportion of the standard map in the detection curve corresponding to the plurality of channels, and obtaining a judgment result according to a preset corresponding relationship between the preset proportion and the plurality of standard maps. The near-infrared brain imaging spectrum analysis method provided by the invention can provide reference for clinical diagnosis.
Owner:北京柚果星空科技有限公司

Three-wavelength vein blood oxygen concentration measuring method

The invention discloses a three-wavelength vein blood oxygen concentration measuring method, a measuring device is composed of a blood oxygen signal, a blood oxygen probe, a signal amplifier, an analog-digital converter and a main controller, the blood oxygen probe collects a blood sample signal, carries out photoelectric conversion, converts a light intensity signal into a frequency signal, carries out signal amplification through a signal amplification circuit, performs ADC conversion, converts the frequency signal into a digital signal, transmits the digital signal to the main controller, the digital signal is processed by the main controller to obtain an electric signal in direct proportion to the light intensity, and the obtained electric signal is substituted into a three-wavelength calculation formula obtained by new derivation to obtain the corresponding venous blood oxygen concentration. According to the three-wavelength vein blood oxygen concentration measuring method, wavelength light sources on absorption points such as reduced hemoglobin and oxyhemoglobin serve as reference light sources, the three-wavelength vein blood oxygen concentration measuring method is obtained through derivation, the anti-interference capacity is higher, measurement is accurate, no time interval is generated in the measuring period, and real-time, continuous and effective parameters can be provided.
Owner:CHONGQING UNIV

FNIRS emotion recognition method and system based on graph network and adaptive denoising

The invention discloses an fNIRS emotion recognition method and system based on a graph network and adaptive denoising, and the method comprises the steps: enabling fNIRS collection equipment to continuously collect the variable quantity of light intensity before and after transmitting-receiving, converting the variable quantity of the light intensity into the change of absorbance, and further obtaining the relative variable quantity of the concentration of oxyhemoglobin and the concentration of deoxidized hemoglobin; de-noising is carried out through a self-adaptive de-noising network model to obtain a pure signal, an input signal of the self-adaptive de-noising network model is the relative variation of the concentration of the oxyhemoglobin and the concentration of the deoxidized hemoglobin obtained in the previous step, and an output signal of the self-adaptive de-noising network model is the relative variation data of the concentration of the pure oxyhemoglobin and the concentration of the deoxidized hemoglobin; mapping of graph nodes is carried out in combination with probe and channel characteristics, brain topology restoration is carried out by using a graph network, and emotion tags are output in a classified manner through a dynamic graph attention emotion recognition network model. The problems that a brain-computer interface is complex to wear, difficult to operate and the like in practical application at present are solved.
Owner:SOUTH CHINA UNIV OF TECH

Mold-in method and apparatus

The present invention mainly relates to a method and apparatus for measuring the concentration of a solute in a solvent. Disclosed is an apparatus or method for determining the concentration of a solute in a solvent of a solution in a container having a time-varying volume by analyzing two signals received from the solution, comprising: measuring the quantity of the two received signals, converting the two signals into two electro-optical or electrical signals, performing a mathematical transformation on the two electro-optical or electrical signals, and determining the ratio of the transformation components of the two electro-optical or electrical signals. The present invention can be used in various applications of determining the ingredient concentration of a fluid, such as a gas or liquid. Particularly, the present invention finds applications in blood analysis in a human body for measuring, for example, the glucose, triglycerol, cholesterol, or oxyhemoglobin concentrations of the blood.
Owner:WANG WEI KUNG

Endoscope system, image processing apparatus, image processing method, and recording medium

An endoscope system includes a light source apparatus configured to generate illumination light to irradiate an object, an image pickup device configured to pick up an image of the object to output an image pickup signal, and a processor configured to generate first color component data corresponding to first light having a center wavelength within a wavelength range where both respective light absorption coefficients in light absorption characteristics of oxyhemoglobin and deoxyhemoglobin are low and second color component data corresponding to second light having a center wavelength in a blue region or a green region based on the image pickup signal, and assign the first color component data to two out of three channels including blue, green, and red channels of an image display apparatus and assign the second color component data to a remaining one of the three channels, to generate an observation image.
Owner:OLYMPUS CORP

Brain-computer interface system based on direct measurement time-of-flight technology, brain-computer interface wearable device and control method thereof

The invention provides a brain-computer interface system based on a direct flight time measurement technology, brain-computer interface wearable equipment and a control method thereof, and the system comprises a processor which is used for controlling the whole brain-computer interface system; a light source module, a photoelectric sensor, a trans-impedance amplifier, an analog-to-digital converter, a first height comparator and a second high-speed comparator. According to the system, a direct time-of-flight (DDoF) measurement technology is applied to the field of functional near-infrared brain-computer interfaces. By directly measuring the time difference between the incident ultrashort pulse near-infrared light and the emergent ultrashort pulse near-infrared light, the passing distance of the near-infrared light in the brain is calculated, and according to the scheme, the absolute value of the concentration of deoxyhemoglobin and oxyhemoglobin in the brain can be measured; and the position of the blood oxygen change of the brain can be directly measured.
Owner:江苏集萃脑机融合智能技术研究所有限公司

Device and method for blood hemoglobin measurement without carboxyhemoglobin interference

A method for blood haemoglobin measurement without carboxyhaemoglobin interference comprises converting oxyhemoglobin, deoxyhemoglobin and methemoglobin into a methemoglobin derivative, i.e. Imidazole-methemoglobin. Imidazole-methemoglobin and carboxyhemoglobin are collectively quantified by the reflectance spectroscopy of the matrix at 525 nm, the isobestic point between Imidazole-methemoglobin complex and carboxyhemoglobin molecule.
Owner:SRIVASTAVA AMBAR

Metabolic rate detection method and detection apparatus

The invention provides metabolic rate detection method and detection apparatus. The metabolic rate detection method comprises the following steps: detecting characteristic light of oxyhemoglobin at asampling site by adopting the metabolic rate detection apparatus; obtaining a time-absorbance curve and a time-absorbance change rate according to absorbance curve of the oxyhemoglobin or the deoxyhemoglobin; and then, obtaining metabolic rate of the sampling site by combining the time-absorbance curve and the time-absorbance change rate with other parameters. The metabolic rate detection apparatus comprises a pressure regulation device, a detection device and a central processor; the pressure regulation device and the detection device are respectively connected with the central processor; thedetection device is used for detecting the characteristic light of the sampling site, as well as sending the characteristic light to the central processor; and the central processor controls pressurization and pressure relief of the pressure regulation device. The metabolic rate detection apparatus is capable of indirectly measuring metabolic rate of the human body; and moreover, the metabolic rate detection apparatus has less interference factors, and is high in accuracy.
Owner:杭州百脉科技有限公司

Method for determining one content in protein and associated devices and methods

A method for determining at least one protein in the blood which is more precise while still being simple to implement. The method exploits in an original way the spectroscopy and the dosing techniques to determine accurately the content in proteins of the biological sample, notably for oxyhemoglobin, methemoglobin, heme bound to serum albumin and hemopexin and bilirubin. Such method can advantageously be used in various applications concerning heme-related or hemoprotein-related disorders, notably method for diagnosing, for following a treatment, for determining biomarkers or for screening. Such a method is also interesting for qualifying blood bags.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
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