123 results about "ORAL DRYNESS" patented technology

The invention is directed to manufacturing and testing methods of electronic intraoral devices for diagnose, monitor and treat local and systemic diseases and conditions for humans and animals. More specifically, the current invention deals with manufacturing techniques, testing methods and a testing apparatus of mainly three types of intra-oral devices: (a) electro-stimulators for various applications such as treatment of dry mouth by stimulating saliva secretion, apnea, sleeping disorders, eating disorders (obesity, anorexia, etc.) dysphagia and others, (b) drug delivery devices; and (c) bio-sensing and monitoring devices. The common parts or the devices are: (1) art electronic module embedded in the device: (2) or a power source being embedded in the device; (3) the devices (or part of them) being placed in the oral cavity.

The present application provides sodium channel blockers exemplified by the following structure:The compounds of the invention useful for treating chronic bronchitis, cystic fibrosis, sinusitis, vaginal dryness, dry eye, Sjogren's disease, distal intestinal obstruction syndrome, dry skin, esophagitis, dry mouth (xerostomia), nasal dehydration, ventilator-induced pneumonia, asthma, primary ciliary dyskinesia, otitis media, chronic obstructive pulmonary disease, emphysema, pneumonia, constipation, and chronic diverticulitis, for example.

A once-a-day oral milnacipran pulsatile release composition has been developed that releases the drug in spaced apart “pulses”. The dosage forms are comprised of first, second and optional third dosage units, with each dosage unit having a different drug release profile. This dosage form provides in vivo drug plasma levels characterized by Cmax below 3000 ng / ml, preferably below 2000 ng / ml, and most preferably below 1000 ng / ml. The composition provides pulsatile release of milnacipran to produce a therapeutic effect over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.

A combination drug therapy can be administered to patients to treat xerostomia or dry mouth or Sjogren's syndrome in the form of orally dissolving film or orally disintegrating tablets. Some of the drugs could be synthetic origin and some drugs are obtained from natural sources.

The present invention discloses an oral composition comprising a combination of probiotic bacteria selected from the group comprising Streptococcus, Eubacterium, Neisseria, Veillonella and pH-rising and / or buffering components, which re-establishes an oral microflora associated with good oral health in subjects with a disturbed oral microflora. The invention also discloses the use of the oral composition in combination with other oral health promoting products to help subjects suffering from disorders such as oral dryness, caries, halitosis, inflamed oral mucous membranes or oral fungal infections to restore good oral health.

An anti-intoxication composition and method of making and using are provided for treating and preventing drinker's remorse and other toxic effects of excessive alcohol consumption by humans. The anti-intoxication composition is an acidic mixture containing sweeteners, flavoring agents, food additives and a processed mixture of metallic salts, sulfuric acid, ammonium sulfate and water. When the anti-intoxication composition is ingested, it promotes the beneficial metabolism of alcohol, primarily ethanol, in the body. The beneficial metabolism results in the conversion of alcohol to amino acids and eliminates the toxic reactions of a hangover, including, but not limited to, a pounding headache, nausea, dry mouth, shaking hands, hypersensitivity to bright lights and sounds.

An apparatus for providing a controlled flow of liquid directly to a user's mouth to alleviate dry mouth conditions. The apparatus consists of a liquid reservoir, a mouthpiece, and a fluid passage between the liquid reservoir and mouthpiece through which liquid from the reservoir is delivered by gravity feed at a controlled rate by a flow control means to the mouthpiece for release into a user's mouth. The mouthpiece is an open sided unitary construction, sized to seat over either the user's upper or lower dentures. Liquid from the liquid reservoir is delivered by the fluid passage to one or more openings within the mouthpiece, and subsequently flows into the user's mouth.

The present invention relates to a method, preferable an oral method, for treating urinary disorders, such as unstable or overactive bladder, while minimizing the occurrences of dry mouth, dyspepsia and reduced stream of tears. The methods of the present invention comprise orally administering to a mammal, preferably a human, a pharmaceutically effective dose of an antimuscarinic agent, such as tolterodine, when needed, whereby a symptomatic relief of urgency and / or frequency is achieved.

An oral moisturizer is disclosed to provide relief from dry mouth. The moisturizer may be provided in different flavors that are palatable, with clinical benefits such as anti-nausea, appetite stimulant, etc., in addition to relief from the deteriorating dental effects of dry mouth. One disclosed oral moisturizer includes glycerin, xylitol, sodium hyaluronate, cetylpyridinium chloride, polysorbate surfactants and a palatable flavor.

It is intended to provide a preventive / remedy for urinary disturbance containing a compound, which shows an acetylcholine esterase inhibitory activity but substantially has no butyrylcholine esterase inhibitory activity, showing no side effect and being safe and efficacious without inhibiting the urine collection function; a preventive / remedy for dry mouth induced by the administration of a remedy for urinary disturbance and a preventive or remedy for hyperactive bladder not accompanied by dry mouth; and a method of screening a substance preventing / treating urinary disturbance without inhibiting the urine collection function characterized by comprising measuring and comparing the acetylcholine esterase inhibitory activity and the butyrylcholine esterase inhibitory activity of a test compound.

A composition and method for the treatment of dry mouth (xerostomia), comprising a sialogogic compound in combination with an effervescent organic acid-based buffering system.

The invention discloses Chinese medicinal composition granules, which comprise the following ruptured powder in part by weight: 6 to 12 parts of ginseng ruptured powder, 4 to 10 parts of American ginseng ruptured powder, and 1 to 7 parts of pseudo-ginseng, wherein the granularity D90 of the ruptured powder is between 5 and 75 mu m. The Chinese medicinal composition granules have the effects of replenishing Qi and nourishing Yin and warming the meridians, and can treat shortness of breath and fatigue, dizziness, palpitations and chest tightness, dry mouth and pharynx, insomnia and dreamful sleep, and other symptoms of deficiency of Qi and Yin, and obstruction of collaterals by blood stasis. In addition, the invention also provides a method for preparing the Chinese medicinal composition granules.

Serum compositions for application to endothelial tissue are described which contain an amniotic fluid extract in combination with embryonic stem cells. Formulations containing the serum composition are also described. The serum compositions and formulations may be used to treat conditions of the mouth such as dry mouth and mouth sores.

The invention discloses a Chinese medicine composition for curing sicca syndrome and a preparation method thereof. The Chinese medicine composition for curing the sicca syndrome mainly comprises the following components by weight: 1200-3000 parts of plaster stone, 200-450 parts of honeysuckle, 70-180 parts of the root barks of the peony trees, 70-180 parts of Indian iphigenia bulb, 200-450 parts of radix gentianae macrophyllae, 2000-450 parts of hedyotis diffusa, 200-450 parts of radix scrophulariae, 70-180 parts of radix puerariae, 200-450 parts of arisaema heterophyllum, 200-450 parts of coix Seeds, 200-450 parts of dried rehamnnia roots, 70-180 parts of radix paeoniae rubra, 200-450 parts of radix astragali and 200-450 parts of Japanese honeysuckle stems. The Chinese medicine composition for curing the sicca syndrome has the effects of nourishing yin, cooling blood, clearing heat, promoting diuresis, tonifying qi and dredging collaterals, and suitable for curing pain caused by dry eyes, dry mouths, dry skins, dry joints and the like.

The invention discloses a traditional Chinese medicine preparation for treating type-2 diabetes, and the traditional Chinese medicine preparation is prepared by the following raw materials according to the mixture ratio by weight: 10-20 parts of radix salviae albae, 10-15 parts of membranous milkvetch root, 10-15 parts of dried rehmannia root, 6-12 parts of barbary wolfberry fruit, 10-15 parts of Mongolian snakegourd root, 5-10 parts of common anemarrhena rhizome, 5-10 parts of kudzuvine root and 1-2 parts of liquoric root. In addition to a certain hypoglycemic effect, the traditional Chinese medicine preparation can significantly improve the type-2 diabetes, in particular to the symptoms of dry mouth and throat, malaise, fatigue, soreness and weakness of waist and knees, burning heat, insomnia, blurred vision, dizziness, heart palpitations, limb numbness and pain, and the like of patients with deficiency of both qi and yin and the blood stasis type diabetes. The greatest feature of the traditional Chinese medicine preparation to be different from the existing technologies is that the radix salviae albae which is the special local herbal medicine in Shandong is firstly applied in the formula for treating the diabetes, thereby effectively improving the clinical treatment effect.

The invention relates to a functional health food and in particular relates to a food for changing damp heat constitution and a preparation process thereof. According to reasonable compatibility of medicines, a synergistic effect can be achieved among the effects of the medicines, and the food has the effects of treating symptoms, such as usual dirty and oily complexion, high probability of acne and comedo, red fur and yellow and greasy tongue nature, bitter taste and dry mouth, somatic heaviness and tiredness, annoyance and slacking, eyestring redness, dry or viscous bound stool, scanty dark urine, and high probability of male scrotal moisture and female leukorrhagia, of people with the damp heat constitution.

The invention relates to a medical biological oral liquid, in particular to a medical biological blood sugar level reducing oral liquid and a preparation method thereof. The oral liquid consists of a bitter gourd extracting solution, a rhizoma polygonati extracting solution, a Chinese yam extracting solution, a rhizoma anemarrhenae extracting solution, a radix polygonati officinalis extracting solution, a radix ophiopogonis extracting solution, a radix rehmanniae extracting solution, a radices trichosanthis extracting solution, a fructus lycii extracting solution, a folium mori extracting solution, a radix puerariae extracting solution, a poria with hostwood extracting solution, a liquorice extracting solution, a platycodon grandiflorum extracting solution, a Rhodiola rosea extracting solution, a rhizoma atractylodis macrocephalae extracting solution, a burdock extracting solution, a schisandra chinensis extracting solution and deionized water. All raw materials are mutually matched, advantages are exerted and disadvantages are overcome, the oral liquid is used for treating symptoms such as weakness of the spleen and the stomach, body fatigue and weakness, dry mouth and reduced appetite, deficiency syndrome of the lung and cough caused by dryness, essence and blood deficiency, internal thermal and consumptive thirst. The oral liquid is capable of clearing heat-fire, helping produce saliva and slake thirst, diminishing swelling and discharging pus, and treating pyreticosis, polydipsia, lung heat, dry cough, internal heat and consumptive thirst, and the oral liquid particularly has a good curative effect for treating diabetes and reducing blood glucose.

The present invention relates to compositions and comestibles that impart a mouth-moistening effect when orally consumed by an individual. More specifically, the compositions of the present invention may include a blend of components, such as a sweetening composition, food-grade acid composition and a cooling agent, that reduces or eliminates the perception of mouth dryness in an individual. The present invention also provides methods for preparing such comestibles, as well as methods of treating xerostomia by orally administering such comestibles.

The present invention provides a composition comprising olive oil, trimethylglycine and xylitol for treating xerostomia and disorders associated thereto, with very good results in increasing the unstimulated salivary flow, in alleviating the symptoms of xerostomia, including the pain associated to xerostomia, as well as improving the quality of life of affected persons. The composition of the invention has also been proved to protect dentin against demineralization in acid conditions.

A non-alcohol mouthwash composition includes: a sweetener, a dispersing agent, a surfactant, an antimicrobial agent, a calcium ion source including calcium lactate, a phosphate ion source including monobasic sodium phosphate, a flavoring agent, a fluoride source, and water. The non-alcohol mouthwash composition includes about 0.001 weight percent of the calcium lactate and about 0.10 weight percent of the monobasic sodium phosphate, based on total weight percent of the non-alcohol mouthwash composition, and the composition has a pH greater than about 5.5. According to embodiments, the non-alcohol mouthwash composition exhibits desirable advantages of being alcohol free, being sodium laural sulfate free, being gluten free, and being substantially 100% natural, as well as alleviating Xerostomia (dry mouth) by stimulating salivary flow, combatting enamel erosion by providing a means of remineralization, providing anticariogenic activity by acting as an antimicrobial agent, and / or providing anti-inflammatory activity, among other benefits.

The present invention relates to peptides and compositions that have antibiofilm properties. In particular, the peptides and compositions of the invention can be used for the treatment or prevention of various conditions including dental caries, gingivitis, periodontitis, oral mucositis, dry mouth and xerostomia.

The present invention relates to orally ingestible compositions also referred to herein as confectionery products for delivery of saliva stimulating and / or saliva substitute to the mouth and throat. The orally ingestible compositions include a core and a shell surrounding the core so that the core is generally centrally or substantially centrally positioned therein. The composition of the core and shell make the confection uniquely suited for the targeted delivery of the saliva stimulating or saliva substitute to the mouth and throat.

An oral composition for the treatment of dry mouth symptoms and other conditions, a method of forming the oral composition, and a method of using the oral composition are disclosed. The oral composition includes a plurality of enzymes to prevent formation of and / or facilitate the break up of biofilm in an oral cavity and a metal ion management system to inhibit growth of gram negative bacteria.

The present invention provides a composition comprising olive oil, trimethylglycine and xylitol for treating xerostomia and disorders associated thereto, with very good results in increasing the unstimulated salivary flow, in alleviating the symptoms of xerostomia, including the pain associated to xerostomia, as well as improving the quality of life of affected persons. The composition of the invention has also been proved to protect dentin against demineralization in acid conditions.

The invention discloses a compound combination medicament for treating COPD, a preparation method and an application thereof. The compound combination medicament comprises the following components by weight: 10 to 60 parts of codonopsis pilosula, 20 to 50 parts of rhubarb, 40 to 100 parts of root of scutellaria, 15 to 60 parts of lapis chlorite (fried), 10 to 60 parts of bighead atractylodes rhizome (fried), 20 to 60 parts of poria cocos, 10 to 100 parts of pinellia, 5 to 70 parts of reddish orange, 15 to 120 parts of ephedra, 10 to 110 parts of almond, 10 to 150 parts of agilawood, 10 to 60 parts of liguisticum chuanxiong, 5 to 160 parts of ginger, and 40 to 200 parts of earthworm. The compound combination medicament provided in the invention is used for treating the COPD at the attack stage and is mainly used for treating spleen-deficiency and lung-heat COPD, wherein the symptoms of the spleen-deficiency and lung-heat COPD are cough, asthma, expectoration with yellow or white mucous sputum, dry excrement, dry mouth, abdominal fullness and distension, flat tongue with tooth mark on it, thin and yellow tongue coating, and wiry and slippery pulse. The compound combination medicament provided in the invention is used for treating the COPD at the attack stage and is mainly used for treating spleen-deficiency and lung-heat COPD, wherein the symptoms of the spleen-deficiency and lung-heat COPD are cough, asthma, expectoration with yellow or white mucous sputum, dry excrement, dry mouth, abdominal fullness and distension, flat tongue with tooth mark on it, thin and yellow tongue coating, and wiry and slippery pulse. The compound combination medicament has advantages of good curative effectiveness, short treating course, thorough treatment, no side effects and the like. Moreover, the compound combination medicament, which is made in a form of mixture, tablet, capsule, pellet, is easy to carry and to take.

The invention discloses a compound thrombus-clearing Chinese medicinal preparation and a preparation method thereof. The compound thrombus-clearing Chinese medicinal preparation comprises active ingredients and / or pharmaceutically acceptable additives which are prepared from the following raw materials: 200 to 1,000 grams of sanchi, 50 to 400 grams of astragalus, 40 to 20 grams of radix salviae miltiorrhizae, 60 to 400 grams of figwort root, and 100 to 800 grams of sanchi decoction dreg powder. The Chinese medicinal preparation has the functions of quickening the blood and transforming stasis, expanding blood vessels, increasing blood flow volume, improving blood circulation and microcirculation and tonifying qi and yin and is mainly used for treating the symptoms of retinal vein occlusion caused by blood stasis and qi and yin deficiency, such as blurred vision or paropsis, eyeground blood stasis, fatigued spirit and lack of strength, dry throat and dry mouth. The Chinese medicinal preparation is also applicable to people with the symptoms of stable exertional angina caused by blood stasis and qi and yin deficiency, such as chest distress, chest pain, palptation, flusteredness, shortness of breath, lack of strength, heart vexation and dry mouth.

The invention provides a mouth wetting agent and a mouth wetting agent for false teeth including a safe and easily usable polymer composition and capable of relieving symptoms of dry mouth by maintaining the wetting properties of an oral cavity and the stability of false teeth. The mouth wetting agent of the invention includes a polymer composition containing a pharmaceutically acceptable water-soluble polymer, a pharmaceutically acceptable polyvalent alcohol and water and / or artificial saliva.

The invention provides anti-inflammatory mouth wash which contains anti-inflammatory components that include vitamin B12 and extractive solution of grosvenor momordica fruits. The vitamin B12 can relieve inflammations of the gum and promote the healing of oral ulcers, has high safety, no irritations, no side effects after long-term use, such as drug resistance of microorganisms, tooth discoloration and oral dryness. The extractive solution of grosvenor momordica fruits in the mouth wash has sweet taste instead of bitter taste of the common herbal extractive solution, has long retention time of sweetness in oral cavity, and provides remarkable effects of reliving cough and throat pain. The invention also provides a preparation method of the anti-inflammatory mouth wash.

The invention discloses toothpaste suitable for diabetes patients. A paste composition of the toothpaste contains 4-12 wt% of body fluid generating components, wherein the body fluid generating components are Acmella uliginosa extracts, Ophiopogon japonicus extracts and Radix Puerariae extracts; the weight percentage of spilanthol in the paste composition of the toothpaste is more than or equal to 0.01%; the weight percentage of Ophiopogon japonicus saponins in the paste composition of the toothpaste is more than or equal to 0.01%; and weight percentage of puerarin in the paste composition of the toothpaste is more than or equal to 0.008%. The toothpaste as oral health care product has the functions of promoting salivary secretion, relieving dryness of the oral cavity and removing bad breath, and can effectively relieve oral and dental disorders of diabetes patients.

Compositions useful for treating membrane-associated diseases, conditions, and disorders, including inflammatory diseases, dry mouth, primary ciliary dyskinesia and platelet aggregating disorders, are disclosed which comprise at least one lantibiotic compound. Also disclosed are pharmaceutical compositions and methods of treatment for membrane-associated diseases such as inflammation and dermal irritation, as well as use of such compositions in the treatment of membrane-associated diseases, wherein the pharmaceutical compositions contain at least one lantibiotic.