A dental device has a U-shaped carrier with at least one channel for embracing an arch of teeth. The carrier has recessed insets in the channel. Discrete inserts carrying a beneficial agent can fit into the insets and release the agent gradually. When the device is used in a primarily therapeutic application, the inserts may be installed into all or less than all of the insets to form various insert patterns. Thus, different oral regions can be affected by different insert patterns. When the device is used as an athletic
mouthguard, temporary blanks may be initially fitted in the insets, while a portion of the
mouthguard is softened before an arch of teeth is pressed into the channel to make a custom impression. The inserts that are later installed in the insets possess different physical properties than the carrier and may be positioned and shaped to mechanically buffer teeth of the arch from mechanical shocks as well as release beneficial agents. The inserts may be replaced or refreshed to maintain the beneficial agent, which may be
xylitol, remineralizing agents, moisturizing agents, desensitizing agents,
flavoring agents, breath fresheners, chemical and biological indicators, nutraceuticals,
antibiotics, probiotics, other medications and chemotherapeutics, or other agents.