33 results about "Nevus flammeus" patented technology

The invention relates to the technical field of medicines and in particular relates to a novel chlorine photosensitizer-pyropheophorbide-a ether amino acid derivative, a preparation method thereof and an application to preparation of antitumor medicines. A chemical structure of the pyropheophorbide-a ether amino acid derivative is shown in a general formula (I) in the specification. The pyropheophorbide-a ether amino acid derivative has the advantages of high efficiency, low toxicity and the like, and can be used for preparing new medicines for photodynamic therapy of cancers, medicines for photodynamic therapy of benign vascular diseases, such as age-related macular degeneration and nevus flammeus and medicines for photodynamic therapy of condyloma acuminate.

The invention relates to novel chlorin e6 derivatives, pharmaceutically acceptable salts thereof, as well as preparation methods and applications of the novel chlorin e6 derivatives and the pharmaceutically acceptable salts and belongs to the technical field of medicines. The chlorin e6 ether amino acid derivatives comprise compounds shown as the general structural formula I and optical isomers ofthe general structural formula I. The preparation method of the novel chlorin e6 derivatives comprises steps as follows: 3-vinyl in chlorin e6 is etherified, and 15-ethylcarboxyl and amino acid are subjected to peptides formation. The chlorin e6 ether amino acid derivatives and the pharmaceutically acceptable salts thereof can be taken as photodynamic antitumor drugs for application. Compared with an existing clinically applied similar photosensitizer talaporfin, the chlorin e6 ether amino acid derivatives have the advantages of being high in photodynamic antitumor activity, high in ratio ofdark toxicity to phototoxicity and the like and can be applied to preparation of new photodynamic antitumor drugs including photodynamic cancer treating drugs, photodynamic treatment drugs for benignvascular diseases such as senile macular degeneration and nevus flammeus as well as photodynamic treatment drugs for condyloma acuminate.

The invention relates to a precision photodynamic therapy system which comprises an intravenous device use for injecting photosensitizer to the human body and a laser used for the illuminating nevus flammeus lesion portion of the human body. The photodynamic therapy system further comprises a digital micromirror device, a weak light detection system and a computer, wherein the weak light detection system is used for motivating and measuring the fluorescence-emission of the photosensitizer and organization spectrum through ultraviolet, and transmitting the detection information to the computer; the computer is used for calculating the concentration distribution of the photosensitizer in an organization according to the detection information, and generating a control signal for controlling the digital micromirror device; the digital micromirror device is used for adjusting the optical intensity distribution iradiated by the laser on the lesion portion under the control of the computer. By means of the precision photodynamic therapy system, the precision light dose delivery can be achieved, treatment effect is improved, and side effects are reduced.

The invention discloses a nevus flammeus photodynamic precise treatment system, which comprises a three-dimensional position adjusting device. The three-dimensional position adjusting device is provided with an imaging CCD, a 45-degree 510 nm mirror and an imaging lens group along a horizontal coaxial optical path. The imaging lens group is provided with a focal length adjusting device. An infrared temperature measuring probe is arranged on the right side of the three-dimensional position adjusting device. A 510 nm LED array is arranged on the front side of the 45-degree 510 nm mirror. An optical power detecting probe and an optical power detecting lens are arranged on the rear side of the 45-degree 510 nm mirror. The optical power detecting lens is disposed between the optical power detecting probe and the 45-degree 510 nm mirror. The system determines the shape and color distribution of the nevus flammeus on the surface of the skin, accurately outputs the spot size and the spot shape, and can adjust the light output power of different parts of the spot to achieve precise treatment, can detect the optical power density in real time, can monitor the surface temperature of the focusin real time, ensures the safety of treatment, has a data upload function capable of uploading system parameters to the cloud server in real time.

The invention discloses a traditional Chinese medicine composition for treating stains and verrucous nevi and a preparing method thereof, and belongs to the technical field of preparation of medicine.The traditional Chinese medicine composition is prepared from, by weight, 3-8 parts of radix angelicae, 15-25 parts of semen coicis, 2-5 parts of herba taraxaci, 2-6 parts of rhizoma atractylodis, 3-6 parts of powder of cornu bubali, 1-8 parts of semen euphorbiae lathyridis, 1-4 parts of tea tree oil, 3-12 parts of oleum fructus bruceae, 5-8 parts of ethyl alcohol, 4-9 parts of glutinous rice flour, 3-4 parts of sodium carbonate, 3-4 parts of calcium hydroxide, 2-5 parts of medical talc powder and 3-8 parts of pearl powder. Main traditional Chinese medicinal materials are cooperative with oneanother and jointly achieve the effects of reliving internal heat or fever, removing blood stasis and disintegrating masses, stopping bleeding by astringency, and relieving internal heat or fever forpromoting tissue regeneration; the composition quickly penetrates through the skin and goes deep into the cells of a part which needs to be subjected to symptom removal, stops the lesions, supplies nutrients to the cells, and kills the lesion cells, and the purposes of removing skin stains and warts like moles are achieved; meanwhile, the traditional Chinese medicine composition can effectively relieve edema or abdominal distension, swelling and pain, and prevent the skin from being infected and festered, and thus it is prevented that scars are not left on the skin after stains and verrucousnevi are cured.

The invention discloses a nevus flammeus color and area assessment method based on digital photo pixel analysis. The assessment method comprises the following steps: 1) making a nevus flammeus reference color card; 2) setting up a photograph environment, taking a face photo and implementing brightness normalization on the face photo; 3) taking color block photos of a nevus flammeus color card in the photograph environment which is set up, and computing a transfer matrix M that RGB values of the color block photos are converted into XYZ three-stimulation values via a polynomial regression method; and 4) computing an L*a*b* color coordinate value of each pixel point of a target area in the face photo in accordance with the transfer matrix M, and implementing color classification as well as color difference and area computation on nevus flammeus in accordance with the L*a*b* values. According to the method provided by the invention, skin color is subjected to accurate and objective quantification via the digital photo, a computed result is similar to a measuring result of a standard spectrocolorimeter and the nevus flammeus undergoes quantitative assessment via objective color values,so that errors, which are caused by subjective reasons when disease conditions are assessed by doctors via naked eyes, are avoided; therefore, a face pigment pathological change recording, analyzingand assessing technology, which is strong in practicability, is provided to the clinical field.

The invention relates to pyropheophorbide-a methyl ether compounds, and a preparation method and application thereof. The compounds have the structure (I) in the specification. The invention relates to the fields of photodynamic therapy and photosensitive drugs (also called photosensitizers or photodynamic drugs), particularly a chlorophyll derivative photosensitizer and a preparation method thereof, and application of the chlorophyll derivative photosensitizer in the field of medicine. The photodynamic drug provided by the invention has the advantages of stable chemical properties, high solubility in water, and very high photodynamic activity, and can be used as a drug for the photodynamic diagnosis and treatment of tumors, retinal macular degeneration, actinic keratosis, nevus flammeus, condylomata acuminata and other diseases.

The invention relates to a novel pyropheophorbide a derivative, a preparation method thereof and medical use. More specifically, the invention relates to a compound with a formula I as shown below, which is defined by the specification. The invention designs and prepares the pyropheophorbide a derivative which is single and stable in structure and simple and convenient in preparation method. The pyropheophorbide a derivative has very strong photodynamic activity, and can be used as a photodynamic drug for diagnosis and treatment of diseases such as tumor, macular degeneration, actinic keratosis, nevus flammeus and condyloma acuminata.

Disclosed is a nevus-dispelling plaster for treating nevus, freckle, senile plaque and flat wart, wherein the weight ratio of plaster includes lime 45-55%, high degree spirit 35-45%, Yunnan baiyao 8-14%, camphor 3-7%.

The present invention is an intelligent PWS photodynamic therapeutic apparatus system, characterized in that the host is an independent therapeutic light source host with a wireless or wired network networking function, the host is connected to the wireless Internet through an independent 4G module, and communicates with the The intelligent control system is composed of PC and intelligent power meter. The intelligent control system transmits data through the Internet, manages the working process of the therapeutic device and collects data in real time. Each unit of the intelligent control system communicates with each other through the 4G network. Data exchange, resource sharing of multiple systems through wireless or wired network, and global interconnection between systems. According to the special requirements of semiconductor narrow-spectrum light source for the treatment of PWS disease, the invention realizes intelligent control of the photodynamic treatment equipment and the whole process of treatment of PWS.

The invention relates to an optimization method of a projection direction used for controlling a projection device for nevus flammeus and the like in a PDT (Photodynamics Therapy). The method comprises the steps of optimizing a lighting direction in accordance with a normal vector weighting corresponding to 3D (three-dimension) surface patch of a focus under the precondition of obtaining a 3D focus area, and reducing a lighting angle formed between incident light and the D surface of the focus. In addition, the projection device can be controlled to light in an optimized direction by using the parameters of a visual system to obtain a position coordinate of the projection device, thereby improving the single lighting efficiency of the projection device and improving the curative effect of the single PDT.

The invention relates to a medicinal composition for treating nevus flammeus and a preparation method thereof, wherein extraction and purification of hypericin are completed by the steps of (a) carrying out crude extraction, (b) refining by macroporous resin and (c) carrying out separation and purification; and the obtained hypericin is mixed with a medicinal carrier in a certain proportion to prepare the medicinal composition. The medicinal composition of the invention has the characteristics of effect on both mild and severe pathological changes, higher curative effect, lower dark toxicity and toxic and side effects, high safety degree, stronger synergistic effect with photodynamic affection, and capacity of addressing both the symptoms and root causes of nevus flammeus without carryingout the allergic test.

A laser apparatus for removing nevus flammeus is composed of a pulse laser power supply with a frequency controllable switch which is serially connected between discharging SCR and high-voltage energy-accumulating capacitor and controlled by a drive module, a solid laser device and a laser output device. Its output laser pulse has wide pulse width and high pulse peak power.