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30 results about "Molecular Computers" patented technology

Molecular computing is a generic term for any computational scheme which uses individual atoms or molecules as a means of solving computational problems.

Methods and systems of brain-like computing virtualization

The invention discloses the technology of brain-like computing virtualization. Brain-like computing means the computing technology to mimic human brain and generate human intelligence automatically with computer software. Here the unconscious engine and conscious engine are used to define human left and right brain, while the virtualization technology is used for software to run on future hardware, such as quantum computer and molecular computer. The applied domain areas include quantum gate and adiabatic quantum simulation, brain-like autonomic computing, traditional multi-core-cluster performance service, software development / service delivery systems, and mission-critical business continuity / disaster recovery.
Owner:TRANSOFT SHANGHAI

DNA colorimetric logic gate construction method based on metal ion regulation and control of exonuclease III shearing action

The invention discloses a DNA colorimetric logic gate construction method based on metal ion regulation and control of exonuclease III shearing action and belongs to the technical field of molecular computer. Double-stranded DNA containing T-T or C-C mismatched base cannot be sheared by exonuclease III. When there exists Hg<2+> or Ag<+>, 3' end completely matched double-stranded DNA formed by action of T-Hg<2+>-T or C-Ag<+>-C can be sheared by exonuclease III, and released single-stranded DNA hybridizes with a DNA signal probe 1 or DNA signal probe 2, thus leading to formation or disintegration of a G-quadruplex structure. Hereby, Hg<2+> and Ag<+> are used as input signals, and logic operation is carried out through the DNA signal probe so as to construct multiple DNA colorimetric logic gates.
Owner:NANCHANG UNIV

Programmable and autonomous computing machine made of biomolecules

A device, system and method for molecular computing which not only includes a suitable, renewable power source, but actually is able to receive power through the performance of the computations themselves. The molecular computing machine of the present invention actually employs the free-energy difference between its input and output to accomplish a computation, preferably by using its input DNA molecule as a partial source of energy, or alternatively by using the input DNA molecule as the sole source of energy. This molecular finite automaton preferably transforms an input DNA molecule into an output DNA molecule by digesting the input as it computes.
Owner:YEDA RES & DEV CO LTD

Computer aided design system for predicting energetic molecule based on machine learning performance

The invention discloses a computer aided design system for predicting energetic molecules based on machine learning performance, and belongs to the technical field of computer aided design systems. The system comprises: a molecule rapid generation module, which is used for generating all possible molecular structural formulas according to permutation and combination of a molecular mother ring anda substituent group input by a user, and removing a repeated structure; a molecular data set module used for recording reported energetic molecular performance data, and the energetic molecular performance data being mainly used as a training set of the machine learning model training module; a molecular descriptor generation module used for calculating molecular descriptors of molecules generatedby the molecular rapid generation module or molecules in the molecular data set module or molecules input by a user; a machine learning model training module used for training and storing a model byadopting a machine learning algorithm according to the data of the molecular descriptor set; and a performance prediction module used for reading the model and carrying out performance prediction on the molecules generated by the molecule rapid generation module or the molecules input by the user.
Owner:INST OF CHEM MATERIAL CHINA ACADEMY OF ENG PHYSICS

Method for information processing with nucleic acid molecules

The present invention is directed to provide an information processing method using autonomously workable nucleic acids, and a molecular computer to carry out operations with the method. Objectives above mentioned may be achieved with following method. The present invention provides an information processing method carrying out operations with functions receiving an argument and returning a return value through chemical reactions of molecules, comprising (a) inputting a first encoded nucleic acid defined in correspondence to a first degradable single stranded nucleic acid as an argument (b) carrying out an operation with functions defined in correspondence to chemical reactions of operator nucleic acids based on the argument (c) obtaining a second encoded nucleic acid defined in correspondence to a second single stranded nucleic acid as a return value. Furthermore, the invention provides a molecular computer designed on the basis of the method.
Owner:OLYMPUS CORP

Autonomous Molecular Computer Diagnoses Molecular Disease Markers and Administers Requisite Drug in Vitro

An autonomous molecular computer that, when coupled to a molecular model of a disease, is capable of disease diagnosis. The computer preferably performs such diagnosis by detecting one or more disease markers. For example, optionally and preferably the molecular computer checks for the presence of over-expressed, under-expressed and mutated genes, applies programmed medical knowledge to this information to reach a diagnostic decision.
Owner:YEDA RES & DEV CO LTD

DNA molecular computer with microflow controlled chips

A DNA molecular computer of miniflow control chip consists of operation media formed by DNA molecule, DNA molecular operator using miniflow control chip as operating platform, DNA molecular storage using DNA molecule as storing media and using miniflow control chip as operating platform, controller using electronic computer and detector as core. It features that controller is connected separately to DNA molecular operator and to electrode on miniflow control chip of DNA molecular storage.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Microfluidic chip-based DNA computer

The present invention relates to computer science, molecular biology and microfluidics technique which provides a DNA molecular computer based on microfluidic chip. The objective is to provide a DNA molecular computer which uses the microfluidic chip as a operation platform, mainly including: using DNA molecules as operation media, using the microfluidic chip as the operation platform of a DNA molecular operator; using DNA molecules as storage media, using the microfluidic chip as the operation platform of a DNA molecular storage; using a electronic computer and a detector as the kernel of a controller; said microfluidic chip includes a DNA molecular computation region and a DNA molecular storage region. The microfluidic chip consists of digestion, ligation, PCR amplification and chip electrophoresis unit connected by microchannels in turn, and carries out the liquid control through micropumps and microvalves.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Reversible molecular electronic device based on technique of scan tunnel microscope and its manufacturing method

An electrically reversible molecular electronic device based on scanning tunnel microtechnique is composed of substrate with an electrically conductive surface having molecular-class smoothness, an organic molecular layer which is a vertically orientated single molecular layer, and the probe which is the needle tip in scanning tunnel microscope. At the action of positive and negative pulses, its states can be reverisibly switched.
Owner:FUDAN UNIV

Micro flew controlling chip for DNA molecula computer

The invention is a microflow control chip for DNA molecular computer, characterized in that: it is integrated with DNA molecular operator and DNA molecular memory. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Synthesis, preparation and application of fluorescent probe for identifying Cys, GSH and HOCl on basis of molecular logic gate

The invention relates to synthesis, preparation and application of a fluorescent probe for identifying Cys, GSH and HOCl on the basis of a molecular logic gate, belongs to the field of small-moleculefluorescent probes and relates to the technical field of molecular computers. The multi-identification fluorescent has a structural formula as shown in a formula (I): ( as shown in the description). The novel fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time, has the advantages of low detection limit, high sensitivity and highselectivity and can realize visible detection; the probe adopts cheap and easily available raw materials, high yield and low preparation cost, and is suitable for industrialized production; a to-be-detected liquid is a buffer solution of 100 percent and is consistent with the buffer ability of the physiological environment in an organism; the molecular logic gate is built by taking the Cys, GSH and HOCl as input signals as well as taking the maximal fluorescence emitting peak fluorescent intensity in the positions of 514 nm and 412 nm as output signals; the fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time and can solve the limitation caused by the single-identification fluorescent probe.
Owner:ZHENGZHOU UNIV

Data coding method based on four-value logic circuit

The invention relates to a data coding method based on a four value logic circuit, and belongs to the technical field of digital circuits. By the data coding method, 2n n-digit binary numbers can be generated. Specifically, 2n registers are used in the method. Under the action of a synchronous clock, to-be-output 2n n-digit binary numbers are set to be paralleled to the corresponding registers according to input and output formulas to obtain 2n n-digit binary integers. The data coding method having the advantage of high parallelism is a basis of research on integrated-circuit based molecular computers.
Owner:BEIJING UNIV OF POSTS & TELECOMM

A quick way to identify ag + Molecular logic gate with three-phase output function of and cys and its construction method

A rapid identification of Ag + The molecular logic gate and the construction method thereof of the three-phase output function of Cys belong to the field of molecular computer technology, which can solve the limitation problem of the single signal output of the existing molecular logic gate, including: using Cys and Ag + As two parallel input signals, the output signals are fluorescence intensity, fluorescence anisotropy and fluorescence lifetime. With berberine as the signal reporting unit, Ag + ‑Nucleic acid aptamer is a molecular recognition substrate, using berberine in Ag + ‑Aptamer and Cys, Ag + The changes of fluorescence intensity, fluorescence anisotropy and fluorescence attenuation in different microenvironments when it exists, construct the basic Boolean logic gate of "forbidden" gate. The constructed molecular logic gate circuit has good performance, high sensitivity, and is easy to distinguish, and can solve the limitation brought by a single output signal.
Owner:SHANXI UNIV

Cobalt oxide-based logic gates with tunable logic functions

The invention relates to the technical fields of nanomaterials, catalysis, analytical chemistry and molecular computer, and in particular, relates to a new variable logic gate application of CoOx nanospheres based on a bovine serum protein template. The prepared CoOx nanospheres not only maintain a stable activity of electrocatalytic reduction of H2O2 in a wide pH range, but also have different influence on the activity under different pH by different metal ions. With use of the characteristic, and with metal ions as input signals, the electrochemical method is applied, the electrochemical response of the CoOx nanosphere activity of electrocatalytic reduction of H2O2 is used as an electrochemical signal, an electrochemical logic gate is constructed and the function of the logic gate is changed by adjusting pH.
Owner:QINGDAO AGRI UNIV

Micro flow controlling chip DNA molecular calculating device

The invention is a microflow control chip DNA molecular computer, comprising operation medium, reaction medium and microflow control chip, where the operation medium comprises special sequence-containing DNA calculating molecules, intermediate operating special sequence-containing DNA transfer molecules and DNA output molecules standing for calculated results; the reaction medium comprises various biochemical enzymes for endonuclease reaction and enzyme-link reaction; and the microflow control chip is provided at least with endonuclease reaction region, enzyme-link reaction region and result output region. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Programmable and autonomous computing machine made of biomolecules

A device, system and method for molecular computing which not only includes a suitable, renewable power source, but actually is able to receive power through the performance of the computations themselves. The molecular computing machine of the present invention actually employs the free-energy difference between its input and output to accomplish a computation, preferably by using its input DNA molecule as a partial source of energy, or alternatively by using the input DNA molecule as the sole source of energy. This molecular finite automaton preferably transforms an input DNA molecule into an output DNA molecule by digesting the input as it computes.
Owner:YEDA RES & DEV CO LTD

A method for constructing a molecular semi-adder and a semi-subtracter

The invention discloses a method for constructing a molecular semi-adder and a molecular semi-subtracter, and belongs to the technical field of molecular computers. The method is characterized in thata Cut Smart buffer solution and a plurality of DNA double chains are taken to construct a logic operation system; two kinds of incision enzymes Nb.BtsI and Nt.BbvCI are used as two paths of parallelinput signals; under the specific cutting action of the cutting endonuclease, the cutting and endonucleating are carried out. According to the half adder and the half subtracter constructed by the method, molecular devices are simple in structure, easy to implement, high in sensitivity, fast in reaction speed, obvious in reaction trend and very low in leakage rate, the output signals are easy to detect, the fluorescent signals of multiple colors clearly represent different signal outputs, and in addition, the method can also be used for accurately detecting the incision enzyme.
Owner:DALIAN UNIVERSITY

Method for constructing DNA colorimetric logic gates based on metal ions regulating exonuclease III cleavage

The invention discloses a DNA colorimetric logic gate construction method based on metal ion regulation and control of exonuclease III shearing action and belongs to the technical field of molecular computer. Double-stranded DNA containing T-T or C-C mismatched base cannot be sheared by exonuclease III. When there exists Hg<2+> or Ag<+>, 3' end completely matched double-stranded DNA formed by action of T-Hg<2+>-T or C-Ag<+>-C can be sheared by exonuclease III, and released single-stranded DNA hybridizes with a DNA signal probe 1 or DNA signal probe 2, thus leading to formation or disintegration of a G-quadruplex structure. Hereby, Hg<2+> and Ag<+> are used as input signals, and logic operation is carried out through the DNA signal probe so as to construct multiple DNA colorimetric logic gates.
Owner:NANCHANG UNIV

Molecular logic gate with three-phase output function for quickly identifying Ag<+> and Cys, and construction method of molecular logic gate

The invention discloses a molecular logic gate with a three-phase output function for quickly identifying Ag<+> and Cys and a construction method of the molecular logic gate, which belong to the technical field of molecular computers, and can solve the problem of limitation of single signal output of an existing molecular logic gate. The molecular logic gate is characterized in that: Cys and Ag<+>are taken as two parallel input signals, and fluorescence intensity, fluorescence anisotropy and fluorescence lifetime are taken as output signals; and an ''inhibit '' gate, namely, a basic Boolean logic gate is constructed by taking berberine as a signal report unit and an Ag<+>-aptamer as a molecular recognition matrix and utilizing changes of fluorescence intensity, fluorescence anisotropy andfluorescence attenuation of the berberine in different microenvironments in the presence of the Ag<+>-aptamer, Cys and Ag<+>. The constructed molecular logic gate circuit is good in performance, highin sensitivity and easy to distinguish, and can solve the limitation caused by a single output signal.
Owner:SHANXI UNIV

Logic gate having adjustable logic function and based on CoOx

The invention relates to the technical fields of nanomaterials, catalysis, analytical chemistry and molecular computer, and in particular, relates to a new variable logic gate application of CoOx nanospheres based on a bovine serum protein template. The prepared CoOx nanospheres not only maintain a stable activity of electrocatalytic reduction of H2O2 in a wide pH range, but also have different influence on the activity under different pH by different metal ions. With use of the characteristic, and with metal ions as input signals, the electrochemical method is applied, the electrochemical response of the CoOx nanosphere activity of electrocatalytic reduction of H2O2 is used as an electrochemical signal, an electrochemical logic gate is constructed and the function of the logic gate is changed by adjusting pH.
Owner:QINGDAO AGRI UNIV

Micro flew controlling chip for DNA molecula computer

The invention is a microflow control chip for DNA molecular computer, characterized in that: it is integrated with DNA molecular operator and DNA molecular memory. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Micro flow controlling chip DNA molecular calculating device

The invention is a microflow control chip DNA molecular computer, comprising operation medium, reaction medium and microflow control chip, where the operation medium comprises special sequence-containing DNA calculating molecules, intermediate operating special sequence-containing DNA transfer molecules and DNA output molecules standing for calculated results; the reaction medium comprises various biochemical enzymes for endonuclease reaction and enzyme-link reaction; and the microflow control chip is provided at least with endonuclease reaction region, enzyme-link reaction region and result output region. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Synthesis, preparation and application of a fluorescent probe for recognizing cys, gsh and hocl based on molecular logic gates

The synthesis, preparation and application of a fluorescent probe that recognizes Cys, GSH and HOCl based on molecular logic gates belongs to the field of small molecule fluorescent probes and relates to the field of molecular computer technology. The multi-recognition fluorescent probe has the formula (I) The structural formula shown: Formula (I) The novel fluorescent probe based on the molecular logic gate of the present invention to identify Cys, GSH and HOCl is reported for the first time, has the advantages of low detection limit, high sensitivity and good selectivity, and can realize visual detection; The probe raw material of the invention is cheap and easy to obtain, the yield is high and the preparation cost is low, and is suitable for industrial production; GSH and HOCl are used as input signals, and the fluorescence intensities of the maximum fluorescence emission peaks at 514 nm and 412 nm are used as output signals to construct molecular logic gates. This is the first reported fluorescent probe based on molecular logic gates to identify Cys, GSH and HOCl. Limitations imposed by identifying fluorescent probes.
Owner:ZHENGZHOU UNIV

DNA molecular computer with microflow controlled chips

A DNA molecular computer of miniflow control chip consists of operation media formed by DNA molecule, DNA molecular operator using miniflow control chip as operating platform, DNA molecular storage using DNA molecule as storing media and using miniflow control chip as operating platform, controller using electronic computer and detector as core. It features that controller is connected separately to DNA molecular operator and to electrode on miniflow control chip of DNA molecular storage.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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