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30 results about "Molecular Computers" patented technology
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Molecular computing is a generic term for any computational scheme which uses individual atoms or molecules as a means of solving computational problems.
Methods and systems of brain-like computing virtualization
The invention discloses the technology of brain-like computing virtualization. Brain-like computing means the computing technology to mimic human brain and generate human intelligence automatically with computer software. Here the unconscious engine and conscious engine are used to define human left and right brain, while the virtualization technology is used for software to run on future hardware, such as quantum computer and molecular computer. The applied domain areas include quantum gate and adiabatic quantum simulation, brain-like autonomic computing, traditional multi-core-cluster performance service, software development / service delivery systems, and mission-critical business continuity / disaster recovery.
Owner:TRANSOFT SHANGHAI
DNA colorimetric logic gate construction method based on metal ion regulation and control of exonuclease III shearing action
The invention discloses a DNA colorimetric logic gate construction method based on metal ion regulation and control of exonuclease III shearing action and belongs to the technical field of molecular computer. Double-stranded DNA containing T-T or C-C mismatched base cannot be sheared by exonuclease III. When there exists Hg<2+> or Ag<+>, 3' end completely matched double-stranded DNA formed by action of T-Hg<2+>-T or C-Ag<+>-C can be sheared by exonuclease III, and released single-stranded DNA hybridizes with a DNA signal probe 1 or DNA signal probe 2, thus leading to formation or disintegration of a G-quadruplex structure. Hereby, Hg<2+> and Ag<+> are used as input signals, and logic operation is carried out through the DNA signal probe so as to construct multiple DNA colorimetric logic gates.
Owner:NANCHANG UNIV
Programmable and autonomous computing machine made of biomolecules
InactiveUS20050075792A1Reduce steric hindranceMicrobiological testing/measurementNanoinformaticsFree energiesAutomaton
A device, system and method for molecular computing which not only includes a suitable, renewable power source, but actually is able to receive power through the performance of the computations themselves. The molecular computing machine of the present invention actually employs the free-energy difference between its input and output to accomplish a computation, preferably by using its input DNA molecule as a partial source of energy, or alternatively by using the input DNA molecule as the sole source of energy. This molecular finite automaton preferably transforms an input DNA molecule into an output DNA molecule by digesting the input as it computes.
Owner:YEDA RES & DEV CO LTD
Computer aided design system for predicting energetic molecule based on machine learning performance
ActiveCN110728047AEfficient designRapid designMolecular computersDesign optimisation/simulationComputer Aided DesignData set
The invention discloses a computer aided design system for predicting energetic molecules based on machine learning performance, and belongs to the technical field of computer aided design systems. The system comprises: a molecule rapid generation module, which is used for generating all possible molecular structural formulas according to permutation and combination of a molecular mother ring anda substituent group input by a user, and removing a repeated structure; a molecular data set module used for recording reported energetic molecular performance data, and the energetic molecular performance data being mainly used as a training set of the machine learning model training module; a molecular descriptor generation module used for calculating molecular descriptors of molecules generatedby the molecular rapid generation module or molecules in the molecular data set module or molecules input by a user; a machine learning model training module used for training and storing a model byadopting a machine learning algorithm according to the data of the molecular descriptor set; and a performance prediction module used for reading the model and carrying out performance prediction on the molecules generated by the molecule rapid generation module or the molecules input by the user.
Owner:INST OF CHEM MATERIAL CHINA ACADEMY OF ENG PHYSICS
Tristable RS trigger capable of supporting multiple value logic
InactiveCN103701450AImplement multivalued logicSimple structureElectric pulse generator detailsLogic circuitsSoftware engineeringNAND gate
The invention relates to a tristable RS trigger capable of supporting the multiple value logic and belongs to the technical field of digital circuits. The tristable RS trigger capable of supporting the multiple value logic comprises three NAND gates (G1, G2 and G3) and two AND gates (AND1 and AND2), wherein two inputs of the tristable RS trigger are S and R, and two outputs of the tristable RS trigger are Q and N; the inputs of four input ends of the G3 are S, R, Q and N respectively; three input ends of the G1 are respectively connected with the output end of the G3, the S and the output end of the AND2; three input ends of the G2 are respectively connected with the output end of the G3, the R and the output end of the AND1; two input ends of the AND1 are connected with the output Q of the G1, and two input ends of the AND2 are connected with the output N of the G2. The tristable RS trigger can obtain 01, 10 and 11 stable states and realize the multiple value logic, is simple in structure and practical, and can be used for providing a technical support for a molecular computer based on a digital circuit.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Method for information processing with nucleic acid molecules
InactiveUS20060141510A1Microbiological testing/measurementNanoinformaticsInformation processingChemical reaction
The present invention is directed to provide an information processing method using autonomously workable nucleic acids, and a molecular computer to carry out operations with the method. Objectives above mentioned may be achieved with following method. The present invention provides an information processing method carrying out operations with functions receiving an argument and returning a return value through chemical reactions of molecules, comprising (a) inputting a first encoded nucleic acid defined in correspondence to a first degradable single stranded nucleic acid as an argument (b) carrying out an operation with functions defined in correspondence to chemical reactions of operator nucleic acids based on the argument (c) obtaining a second encoded nucleic acid defined in correspondence to a second single stranded nucleic acid as a return value. Furthermore, the invention provides a molecular computer designed on the basis of the method.
Owner:OLYMPUS CORP
Autonomous Molecular Computer Diagnoses Molecular Disease Markers and Administers Requisite Drug in Vitro
InactiveUS20070299645A1NanoinformaticsAnalogue computers for chemical processesDisease causeDisease injury
An autonomous molecular computer that, when coupled to a molecular model of a disease, is capable of disease diagnosis. The computer preferably performs such diagnosis by detecting one or more disease markers. For example, optionally and preferably the molecular computer checks for the presence of over-expressed, under-expressed and mutated genes, applies programmed medical knowledge to this information to reach a diagnostic decision.
Owner:YEDA RES & DEV CO LTD
Method for virtualization of a brain-like computing system
Owner:TRANSOFT SHANGHAI
DNA molecular computer with microflow controlled chips
A DNA molecular computer of miniflow control chip consists of operation media formed by DNA molecule, DNA molecular operator using miniflow control chip as operating platform, DNA molecular storage using DNA molecule as storing media and using miniflow control chip as operating platform, controller using electronic computer and detector as core. It features that controller is connected separately to DNA molecular operator and to electrode on miniflow control chip of DNA molecular storage.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Microfluidic chip-based DNA computer
The present invention relates to computer science, molecular biology and microfluidics technique which provides a DNA molecular computer based on microfluidic chip. The objective is to provide a DNA molecular computer which uses the microfluidic chip as a operation platform, mainly including: using DNA molecules as operation media, using the microfluidic chip as the operation platform of a DNA molecular operator; using DNA molecules as storage media, using the microfluidic chip as the operation platform of a DNA molecular storage; using a electronic computer and a detector as the kernel of a controller; said microfluidic chip includes a DNA molecular computation region and a DNA molecular storage region. The microfluidic chip consists of digestion, ligation, PCR amplification and chip electrophoresis unit connected by microchannels in turn, and carries out the liquid control through micropumps and microvalves.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Reversible molecular electronic device based on technique of scan tunnel microscope and its manufacturing method
InactiveCN1445160AMeet storage needsIndividual molecule manipulationNanoinformaticsElectricityElectrical polarity
An electrically reversible molecular electronic device based on scanning tunnel microtechnique is composed of substrate with an electrically conductive surface having molecular-class smoothness, an organic molecular layer which is a vertically orientated single molecular layer, and the probe which is the needle tip in scanning tunnel microscope. At the action of positive and negative pulses, its states can be reverisibly switched.
Owner:FUDAN UNIV
Micro flew controlling chip for DNA molecula computer
The invention is a microflow control chip for DNA molecular computer, characterized in that: it is integrated with DNA molecular operator and DNA molecular memory. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Synthesis, preparation and application of fluorescent probe for identifying Cys, GSH and HOCl on basis of molecular logic gate
ActiveCN109912612ALow detection limitSensitive highOrganic chemistryFluorescence/phosphorescenceMolecular logic gateStructural formula
The invention relates to synthesis, preparation and application of a fluorescent probe for identifying Cys, GSH and HOCl on the basis of a molecular logic gate, belongs to the field of small-moleculefluorescent probes and relates to the technical field of molecular computers. The multi-identification fluorescent has a structural formula as shown in a formula (I): ( as shown in the description). The novel fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time, has the advantages of low detection limit, high sensitivity and highselectivity and can realize visible detection; the probe adopts cheap and easily available raw materials, high yield and low preparation cost, and is suitable for industrialized production; a to-be-detected liquid is a buffer solution of 100 percent and is consistent with the buffer ability of the physiological environment in an organism; the molecular logic gate is built by taking the Cys, GSH and HOCl as input signals as well as taking the maximal fluorescence emitting peak fluorescent intensity in the positions of 514 nm and 412 nm as output signals; the fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time and can solve the limitation caused by the single-identification fluorescent probe.
Owner:ZHENGZHOU UNIV
Data coding method based on four-value logic circuit
InactiveCN104363014ALogic circuits characterised by logic functionDecoding methodsComputer architecture
The invention relates to a data coding method based on a four value logic circuit, and belongs to the technical field of digital circuits. By the data coding method, 2n n-digit binary numbers can be generated. Specifically, 2n registers are used in the method. Under the action of a synchronous clock, to-be-output 2n n-digit binary numbers are set to be paralleled to the corresponding registers according to input and output formulas to obtain 2n n-digit binary integers. The data coding method having the advantage of high parallelism is a basis of research on integrated-circuit based molecular computers.
Owner:BEIJING UNIV OF POSTS & TELECOMM
A quick way to identify ag + Molecular logic gate with three-phase output function of and cys and its construction method
ActiveCN111122523BImprove accuracyHigh sensitivityBiomolecular computersFluorescence/phosphorescenceAptamerBerberine
A rapid identification of Ag + The molecular logic gate and the construction method thereof of the three-phase output function of Cys belong to the field of molecular computer technology, which can solve the limitation problem of the single signal output of the existing molecular logic gate, including: using Cys and Ag + As two parallel input signals, the output signals are fluorescence intensity, fluorescence anisotropy and fluorescence lifetime. With berberine as the signal reporting unit, Ag + ‑Nucleic acid aptamer is a molecular recognition substrate, using berberine in Ag + ‑Aptamer and Cys, Ag + The changes of fluorescence intensity, fluorescence anisotropy and fluorescence attenuation in different microenvironments when it exists, construct the basic Boolean logic gate of "forbidden" gate. The constructed molecular logic gate circuit has good performance, high sensitivity, and is easy to distinguish, and can solve the limitation brought by a single output signal.
Owner:SHANXI UNIV
Cobalt oxide-based logic gates with tunable logic functions
ActiveCN108362816BStable electrocatalytic reductionHigh activityChemical analysis using catalysisMaterial electrochemical variablesElectrochemical responsePhysical chemistry
The invention relates to the technical fields of nanomaterials, catalysis, analytical chemistry and molecular computer, and in particular, relates to a new variable logic gate application of CoOx nanospheres based on a bovine serum protein template. The prepared CoOx nanospheres not only maintain a stable activity of electrocatalytic reduction of H2O2 in a wide pH range, but also have different influence on the activity under different pH by different metal ions. With use of the characteristic, and with metal ions as input signals, the electrochemical method is applied, the electrochemical response of the CoOx nanosphere activity of electrocatalytic reduction of H2O2 is used as an electrochemical signal, an electrochemical logic gate is constructed and the function of the logic gate is changed by adjusting pH.
Owner:QINGDAO AGRI UNIV
A tri-stable rs flip-flop supporting multi-valued logic
InactiveCN103701450BImplement multivalued logicSimple structureElectric pulse generator detailsLogic circuitsStable stateEngineering
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Reversible molecular electronic device based on technique of scan tunnel microscope and its manufacturing method
InactiveCN1206157CMeet storage needsIndividual molecule manipulationNanoinformaticsElectrical polarityMolecular switch
The invention belongs to the technical field of molecular electronic devices, and in particular relates to an electrically reversible molecular electronic device based on scanning tunneling microscopy technology and a manufacturing method thereof. This molecular electronic device consists of a substrate, an organic molecular layer, and a probe. Among them, the substrate adopts an atomically flat conductive surface, the probe adopts a needle tip in a scanning tunneling microscope, and the organic molecular layer is a vertically oriented monolayer. The organic molecules are elongated π-conjugated molecules containing polar groups. This molecular electronic device can be reversibly switched with an external forward and reverse pulse voltage, that is, it can be erased and written, and can be read with a very low operating voltage. The molecular electronic device of the invention can be used as an electrically erasable ultra-high-density memory, a molecular switch, a logic element, etc., and has wide application value in molecular computers.
Owner:FUDAN UNIV
Micro flow controlling chip DNA molecular calculating device
The invention is a microflow control chip DNA molecular computer, comprising operation medium, reaction medium and microflow control chip, where the operation medium comprises special sequence-containing DNA calculating molecules, intermediate operating special sequence-containing DNA transfer molecules and DNA output molecules standing for calculated results; the reaction medium comprises various biochemical enzymes for endonuclease reaction and enzyme-link reaction; and the microflow control chip is provided at least with endonuclease reaction region, enzyme-link reaction region and result output region. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Programmable and autonomous computing machine made of biomolecules
InactiveUS7970547B2Reduce steric hindranceMicrobiological testing/measurementNanoinformaticsFree energiesAutomaton
A device, system and method for molecular computing which not only includes a suitable, renewable power source, but actually is able to receive power through the performance of the computations themselves. The molecular computing machine of the present invention actually employs the free-energy difference between its input and output to accomplish a computation, preferably by using its input DNA molecule as a partial source of energy, or alternatively by using the input DNA molecule as the sole source of energy. This molecular finite automaton preferably transforms an input DNA molecule into an output DNA molecule by digesting the input as it computes.
Owner:YEDA RES & DEV CO LTD
Novel computation with nucleic acid molecules, computer and software for computing
InactiveUS20070156351A1Increase speedNanoinformaticsAnalogue computers for chemical processesComputer scienceSoftware
The present invention is to provide a molecular computer comprising an electronic operation section and a molecular operation section, wherein, in addition to general computation processing, said electronic operation section controls a function of the molecular operation section substantially, and the molecular operation is performed under control thereof.
Owner:OLYMPUS OPTICAL CO LTD
A method for constructing a molecular semi-adder and a semi-subtracter
ActiveCN109885278AQuick responseShort reaction timeDigital data processing detailsMicrobiological testing/measurementFluorescenceReaction speed
The invention discloses a method for constructing a molecular semi-adder and a molecular semi-subtracter, and belongs to the technical field of molecular computers. The method is characterized in thata Cut Smart buffer solution and a plurality of DNA double chains are taken to construct a logic operation system; two kinds of incision enzymes Nb.BtsI and Nt.BbvCI are used as two paths of parallelinput signals; under the specific cutting action of the cutting endonuclease, the cutting and endonucleating are carried out. According to the half adder and the half subtracter constructed by the method, molecular devices are simple in structure, easy to implement, high in sensitivity, fast in reaction speed, obvious in reaction trend and very low in leakage rate, the output signals are easy to detect, the fluorescent signals of multiple colors clearly represent different signal outputs, and in addition, the method can also be used for accurately detecting the incision enzyme.
Owner:DALIAN UNIVERSITY
Method for constructing DNA colorimetric logic gates based on metal ions regulating exonuclease III cleavage
The invention discloses a DNA colorimetric logic gate construction method based on metal ion regulation and control of exonuclease III shearing action and belongs to the technical field of molecular computer. Double-stranded DNA containing T-T or C-C mismatched base cannot be sheared by exonuclease III. When there exists Hg<2+> or Ag<+>, 3' end completely matched double-stranded DNA formed by action of T-Hg<2+>-T or C-Ag<+>-C can be sheared by exonuclease III, and released single-stranded DNA hybridizes with a DNA signal probe 1 or DNA signal probe 2, thus leading to formation or disintegration of a G-quadruplex structure. Hereby, Hg<2+> and Ag<+> are used as input signals, and logic operation is carried out through the DNA signal probe so as to construct multiple DNA colorimetric logic gates.
Owner:NANCHANG UNIV
Molecular logic gate with three-phase output function for quickly identifying Ag<+> and Cys, and construction method of molecular logic gate
ActiveCN111122523AImprove accuracyHigh sensitivityBiomolecular computersFluorescence/phosphorescenceAptamerBerberine
The invention discloses a molecular logic gate with a three-phase output function for quickly identifying Ag<+> and Cys and a construction method of the molecular logic gate, which belong to the technical field of molecular computers, and can solve the problem of limitation of single signal output of an existing molecular logic gate. The molecular logic gate is characterized in that: Cys and Ag<+>are taken as two parallel input signals, and fluorescence intensity, fluorescence anisotropy and fluorescence lifetime are taken as output signals; and an ''inhibit '' gate, namely, a basic Boolean logic gate is constructed by taking berberine as a signal report unit and an Ag<+>-aptamer as a molecular recognition matrix and utilizing changes of fluorescence intensity, fluorescence anisotropy andfluorescence attenuation of the berberine in different microenvironments in the presence of the Ag<+>-aptamer, Cys and Ag<+>. The constructed molecular logic gate circuit is good in performance, highin sensitivity and easy to distinguish, and can solve the limitation caused by a single output signal.
Owner:SHANXI UNIV
A quad-stable rs flip-flop supporting multi-valued logic
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Logic gate having adjustable logic function and based on CoOx
ActiveCN108362816AStable electrocatalytic reductionChemical analysis using catalysisMaterial electrochemical variablesElectrochemical responseElectrochemistry
The invention relates to the technical fields of nanomaterials, catalysis, analytical chemistry and molecular computer, and in particular, relates to a new variable logic gate application of CoOx nanospheres based on a bovine serum protein template. The prepared CoOx nanospheres not only maintain a stable activity of electrocatalytic reduction of H2O2 in a wide pH range, but also have different influence on the activity under different pH by different metal ions. With use of the characteristic, and with metal ions as input signals, the electrochemical method is applied, the electrochemical response of the CoOx nanosphere activity of electrocatalytic reduction of H2O2 is used as an electrochemical signal, an electrochemical logic gate is constructed and the function of the logic gate is changed by adjusting pH.
Owner:QINGDAO AGRI UNIV
Micro flew controlling chip for DNA molecula computer
The invention is a microflow control chip for DNA molecular computer, characterized in that: it is integrated with DNA molecular operator and DNA molecular memory. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Micro flow controlling chip DNA molecular calculating device
The invention is a microflow control chip DNA molecular computer, comprising operation medium, reaction medium and microflow control chip, where the operation medium comprises special sequence-containing DNA calculating molecules, intermediate operating special sequence-containing DNA transfer molecules and DNA output molecules standing for calculated results; the reaction medium comprises various biochemical enzymes for endonuclease reaction and enzyme-link reaction; and the microflow control chip is provided at least with endonuclease reaction region, enzyme-link reaction region and result output region. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Synthesis, preparation and application of a fluorescent probe for recognizing cys, gsh and hocl based on molecular logic gates
ActiveCN109912612BLow detection limitSensitive highOrganic chemistryFluorescence/phosphorescenceFluoProbesStructural formula
The synthesis, preparation and application of a fluorescent probe that recognizes Cys, GSH and HOCl based on molecular logic gates belongs to the field of small molecule fluorescent probes and relates to the field of molecular computer technology. The multi-recognition fluorescent probe has the formula (I) The structural formula shown: Formula (I) The novel fluorescent probe based on the molecular logic gate of the present invention to identify Cys, GSH and HOCl is reported for the first time, has the advantages of low detection limit, high sensitivity and good selectivity, and can realize visual detection; The probe raw material of the invention is cheap and easy to obtain, the yield is high and the preparation cost is low, and is suitable for industrial production; GSH and HOCl are used as input signals, and the fluorescence intensities of the maximum fluorescence emission peaks at 514 nm and 412 nm are used as output signals to construct molecular logic gates. This is the first reported fluorescent probe based on molecular logic gates to identify Cys, GSH and HOCl. Limitations imposed by identifying fluorescent probes.
Owner:ZHENGZHOU UNIV
DNA molecular computer with microflow controlled chips
A DNA molecular computer of miniflow control chip consists of operation media formed by DNA molecule, DNA molecular operator using miniflow control chip as operating platform, DNA molecular storage using DNA molecule as storing media and using miniflow control chip as operating platform, controller using electronic computer and detector as core. It features that controller is connected separately to DNA molecular operator and to electrode on miniflow control chip of DNA molecular storage.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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