32 results about "Microdosing" patented technology

A microdosing apparatus comprises a fluid conduit having a flexible tube with a first end for connecting to a fluid reservoir and a second end where an outlet opening is located. An actuating device with a displacer with adjustable hub is provided, by which the volume of a portion of the flexible hub can be changed to thereby dispense liquid as free flying droplets or as free flying jet at the outlet opening by moving the displacer between a first end position and a second end position, whereby the tube is partly compressed in the first or the second end position. In other words, a microdosing apparatus comprises fluid conduit having a portion along which a cross section of the fluid conduit is variable by an actuating device to effect a change of the volume of the fluid conduit. A ratio of a fluidic impedance between the position of the actuating device and the outlet opening to a fluidic impedance between a first end of the fluid conduit and the position of the actuating device is variable by changing the position of the actuating device, so that a dosing volume dispensed at the outlet opening is variable thereby by at least 10%.

The present disclosure provides methods and devices for delivering pilocarpine to the eye. In certain aspects, the disclosure provides method for delivering a composition comprising pilocarpine to an eye of a subject in need thereof as a micro-dose stream of droplets. In certain embodiments, the method treats or alleviates one or more symptoms of presbyopia, in particular presbyopia in adults 40 years of age or older, in the subject in need thereof. In certain embodiments, the present disclosure utilizes relatively high concentrations of pilocarpine in the solution to be administered and as a single active agent.

The invention relates to a method as well as a microdosing system for dosing an amount of fluid to be dispensed, wherein the microdosing system includes a micropump including an inlet and an outlet and configured to suck the fluid to be dispensed through the inlet and to dispense at least part of the fluid from the outlet. Further, the inventive microdosing system includes a first flow sensor arranged on the inlet side or the outlet side having an opening and a flow rate meter, wherein the flow rate meter is configured to determine the flow rate of the fluid passing through this opening. Additionally, the inventive microdosing system includes calibrators and / or fault detectors of the first flow sensor.

The invention provides a safety valve assembly suitable for micro-dose infusion, a micro-dose secretion pump and an insulin pump. The safety valve assembly comprises a valve body, a flexible body and a needle withdrawing unit. The valve body is connected with a medium output device, the flexible body is connected between the valve body and the medium output device, and the needle withdrawing unit is connected with the valve body; the medium output device is provided with a medium inlet and outlet and a flexible body driving port, a first pipeline is arranged in the valve body, the input end of the first pipeline is connected with the medium inlet and outlet, the output end of the first pipeline is located on one side of the flexible body, and the flexible body driving port is located on the other side of the flexible body; and the sectional area of the medium inlet and outlet is smaller than that of the flexible body driving port. The problem that the medium injection speed is too high in the output failure process of medium output device can be solved, and under certain application conditions such as insulin or medicament injection, excessive injection can cause life danger.

A fluid sample dispenser includes a microdosing device for outputting, during an activation state, a fluid sample at a fluid sample outlet to the environment, wherein the microdosing device is placeable adjacent to a person's nose so that a distance between the outlet of the microdosing device and a nostril of the person's nose is within a predefined range, and a microdosing driver unit for adjusting a dosing rate of the scent sample output at the scent sample outlet by selectively activating the microdosing device.

To detect pressure changes in the fluid flow path (2) of a micro-dosing unit, i.e. an insulin pump (1), an emitter (4) and a sensor (5) in the housing (20) register a bulge at the membrane (7) in a body (3), indicating a blockage in the flow path causing a shift in the pressure. The body can be changed once or a number of times while the sensor and emitter remain

Post-bariatric hypoglycemia (PBH) is an increasingly-recognized complication of gastric bypass surgery. Current therapeutic options have suboptimal efficacy. Small doses of stable liquid glucagon canbe used to treat or prevent post-bariatric hypoglycemia.

The invention discloses a tissue equivalent correction method for a micro-dose detector, which belongs to the technical field of radiation measurement and radiation protection. The average incident energy of particles entering the micro-dose detector under certain conditions; calculate the linear stopping power ratio of the biological tissue material and the micro-dose detector material under the current incident energy; normalize the deposition energy distribution; Transform the normalized distribution; calculate the expected value ratio of the normalized distribution and the transformed distribution; calculate the deposition energy distribution of the biological tissue material according to the transformed distribution and the expected value ratio 。 The invention can accurately convert the deposition energy distribution measured by the detector into the deposition energy distribution in the biological tissue under the same condition.

This application is directed to a method of microdosing by dissolving drug in water and permitting a human or animal to consume the drug during waking hours. Metering for an animal is the amount of water they drink, in the pattern as consumed. By setting drug concentration so that a target dose will be consumed in a typical amount of daily drinking water, the dose is spread out into a series of smaller doses over time. For a human, this can be metered more specifically and thoughtfully. A mechanism to make this convenient for humans is provided. A model of blood levels is described. The clinical benefits are greater than predicted from extrapolating from a daily dose to dosing twice a day to a projected 6-12 times a day with the microdosing method.

The invention provides a dose-controllable medium conveying structure, a medium conveying method and a micro-dose secretion pump. The dose-controllable medium conveying structure comprises a dose output assembly, the dose output assembly comprises a first multi-way valve, a second multi-way valve and a cavity, a sealing piece is connected in the cavity, a first cavity space on one side of the sealing piece and a second cavity space on the other side of the sealing piece are independent of each other through the sealing piece, and the size of the first cavity space and the size of the second cavity change along with movement or deformation of the sealing piece. The direction of an external medium entering the dose output assembly is controlled by controlling the conduction directions of thefirst multi-way valve and the second multi-way valve; and through the pressure of the medium entering the first cavity space / the second cavity space, the sealing piece moves or deforms, the second cavity space / the first cavity space is extruded, and the medium in the second cavity space / the first cavity space is discharged. According to the invention, the effect of one-time dose delivery can be accurate, and the dose delivered for one time cannot be changed due to the influence of external factors.

The invention discloses a high-flux medicine decoction and collection device and method. The device comprises a plurality of decoction units, wherein the decoction units are arranged in an array mode;each decoction unit comprises a pressurizing chamber, a decoction, a heater and a collection capillary pipeline; air resistors are arranged on the walls of the pressurizing chambers; the air resistors are connected with the walls of the pressurizing chambers through return springs; the decoction chambers are connected with the pressurizing chambers through the air resistors; filtering membranes are arranged on the walls of the decoction chambers; the heaters are used for heating the decoction chambers; one end of each collection capillary pipeline is connected with the filtering membrane of each decoction chamber through a switch part. As multiple decoction units of an identical structure are arranged in the array mode, traditional Chinese medicines of micro dosages can be simultaneouslydecocted in a large-scale mode, and a decoction function of high fluxes and micro reactions can be achieved; and in addition, a decoction collection mode of pressurization and filtering membranes ensures that a decoction can be sufficiently collected even in case of a micro dosage, and the problem that the decoction cannot be sufficiently separated from medicine residues can be solved.

A nozzle is provided herein for ophthalmic dispensers which is configured to accommodate microdosing. The nozzle includes a converging pathway. Preferably, the pathway converges so as to impart momentum to liquid passing therethrough through an increase of velocity. A tapered portion may be provided flared openly from the inlet to best accept liquid flow thereinto and provide a funneling effect into the flowpath. Preferably, the flowpath terminates at an outlet which is internally un-radiused and circumscribed by a chamfered surface.

A dosing system for transferring an aseptic fluid in dosages into a container, comprising a peristaltic pump configured such that the filling accuracy for fill volumes of the aseptic fluid <100 μL is ±3 μL.

The invention relates to a biological dose calculation method for boron neutron capture therapy (BNCT). The method of the present invention is based on neutron autoradiography technology to realize accurate measurement of tumor cell scale and tumor / normal tissue vascular boron concentration distribution; according to the distribution characteristics of different boron drugs, neutron energy spectrum and tissue material characteristics, through Monte Carlo simulation and The microdosimetry biological model constructs the corresponding relationship between boron distribution and neutron energy and the relative biological effect (RBE) or composite biological effect (CBE) of each BNCT ray component; constructs a patient's individualized radiation simulation human body model based on medical image data, and then The three-dimensional dose distribution is obtained; according to the contours of the tumor target area and normal organs, and combined with the three-dimensional physical dose distribution and biological effect factors to obtain the equivalent biological dose, the dose-volume histogram (DVH map) of the tumor and normal tissues and organs is calculated, which is The theoretical basis is provided for the design of new targeted drugs and the biological transformation of precise BNCT clinical treatment plans.