A kind of device and medium used in boron neutron capture therapy biological dose calculation method

Abstract

The invention relates to a biological dose calculation method for boron neutron capture therapy (BNCT). The method of the present invention is based on neutron autoradiography technology to realize accurate measurement of tumor cell scale and tumor / normal tissue vascular boron concentration distribution; according to the distribution characteristics of different boron drugs, neutron energy spectrum and tissue material characteristics, through Monte Carlo simulation and The microdosimetry biological model constructs the corresponding relationship between boron distribution and neutron energy and the relative biological effect (RBE) or composite biological effect (CBE) of each BNCT ray component; constructs a patient's individualized radiation simulation human body model based on medical image data, and then The three-dimensional dose distribution is obtained; according to the contours of the tumor target area and normal organs, and combined with the three-dimensional physical dose distribution and biological effect factors to obtain the equivalent biological dose, the dose-volume histogram (DVH map) of the tumor and normal tissues and organs is calculated, which is The theoretical basis is provided for the design of new targeted drugs and the biological transformation of precise BNCT clinical treatment plans.

Description

technical field [0001] The present invention relates to the technical field of radiation therapy, in particular to a method for calculating biological dose of boron neutron capture therapy. Background technique [0002] According to China's latest cancer data "China Cancer Report" released by the National Cancer Center, about 10,000 people are diagnosed with cancer every day, and cancer has become the number one killer threatening the health of our people. As one of the three main methods of cancer treatment, radiotherapy has always pursued the goal of increasing the radiation dose to the tumor area during radiotherapy to kill the tumor, and at the same time reducing the radiation dose to normal tissues to reduce damage to normal tissues . An ideal precision radiotherapy technology should kill tumor cells with high selectivity and high lethality at the micron scale, and BNCT is a radiotherapy technology with this characteristic. It injects a boron-containing compound into t...

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Problems solved by technology

In addition, some researchers proposed to use the MKM model, the accuracy of which is controversial and lacks wide applicability

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