46 results about "Methoxystemofoline" patented technology

The invention relates to a synthetic technology of p-methoxystyrene, which comprises: using p-methoxyhypnone as a raw material, reducing to p-methoxy-alpha-methylbenzylalcohol by a reducing agent, adding a small quantity of weakly acidic catalyst to the p-methoxy-alpha-methylbenzylalcohol, agitating and reacting for a period of time, taking liquid, and flowing the liquid through a tubular reactor under negative pressure to generate the p-methoxystyrene, wherein the tubular reactor is used for replacing the reactor units such as traditional reaction kettles and the like, continuous production can be conveniently carried out and production cost is greatly decreased.

Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

The invention provides a synthesis method of resveratrol, and belongs to the technical field of natural product synthesis. The synthesis method comprises the following steps: with 3,5-dimethoxy benzoic acid as a raw material, generating 3,5-dimethoxy benzoyl chloride (12) through an acylating chlorination reaction; generating 3,5-dimethoxy benzamide (13) through an amidation reaction of the (12);generating 3,5-dimethoxyaniline (14) through a Hofmann degradation reaction of the (13); generating 3,5-dimethoxy iodobenzene (15) through a Sandmeyer reaction on the (14); generating 3,5,4'-trimethoxy diphenylethene (31) through a reaction between the (15) and p-methoxystyrene (23), and performing demethylation of the (31) to finally obtain resveratrol (1), wherein total yield is 23.3%. Accordingto the method, the adopted reagent is cheap and easily available, aftertreatment is simple, and two expensive intermediates for Heck reaction are synthesized by adopting cheap raw materials. A new synthesis method is provided for synthesizing resveratrol.

The present invention provides a method of treating behavioral disorders such as attention deficit hyperactivity disorder, comprising administering an effective amount of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methylxanthine or a pharmaceutically acceptable salt thereof to a patient in need thereof and the like.

A process for synthesizing 4-methoxy styrene includes reductive reaction of 4-methoxy acetophenone to obtain 4-(4'-methoxyphenyl) ethanol, esterifying reaction to obtain 1-(4'-methoxyphenyl) ethyl sulfonate, abate reaction to obtain 4-methoxy styrene, and vacuum rectifying.

Pharmaceutical compositions of (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone and pharmaceutically acceptable salts thereof are described as well as methods of their use.

The invention discloses 1,3-bis(2-bromo-5-methoxylstyryl)-2,4,6-trinitrobenzene and a preparation method thereof. The preparation method comprises the following steps: adding 1,3-bis(3-methoxylstyryl)-2,4,6-trinitrobenzene, liquid bromine, and a catalyst into a reactor, taking dichloromethane as the solvent, carrying out reactions at the room temperature, after reactions, filtering, neutralizing the filtrate by a saturated sodium carbonate solution, extracting the filtrate by dichloromethane, carrying out spinning evaporation, and finally drying to obtain 1,3-bis(2-bromo-5-methoxylstyryl)-2,4,6-trinitrobenzene. Each benzene ring on the periphery of 1,3-bis(2-bromo-5-methoxylstyryl)-2,4,6-trinitrobenzene contains a bromine atom, the symmetrical property is good, moreover, the central benzene ring is connected to two other benzene rings through two conjugated double bonds, and thus the stability of the compound is greatly improved. The provided compound can be used to produce functional materials used in the fields such as medicine, pesticide, heatproof materials, and the like.

The invention discloses a synthesis method of resveratrol. The synthesis method comprises the steps of a preparation technology of 3,5-dibromo-4-aminotoluene, a preparation technology of 3, 5-dibromotoluene, a preparation technology of (E)-1,3-dibromo-5-(4-methoxy-styrene)benzene, a preparation technology of (E)-1,3-dimethoxy-5-(4-methoxy-styrene)benzene and a preparation technology of resveratrol. The synthesis method has the advantages of being low in raw material price, less in step, high in yield and suitable for scale production.

The invention discloses a compound dimethoxystyryl-amino-benzimidazolyl-triazine and salt thereof as well as a preparation method and application. The compound 2-[(E)-3',4'-dimethoxystyryl]-4-amino-[1, 2]-benzimidazolyl-[1, 3, 5]-triazine has a good anti-tumor activity against a plurality of tumor cell lines, and obviously influencesan obvious influence on the tumor cell microtubules, wherein theeffect on the cell microtubules is in positive correlation with the time and the concentration, and the compound has a broad application prospect in the anti-tumor field; meanwhile, the preparation method of the compound 2-[(E)-3',4'-dimethoxystyryl]-4-amino-[1, 2]-benzimidazolyl-[1, 3, 5]-triazine has the advantages of simple technology and low equipment requirements and promotes large-scale production.

Pharmaceutical compositions of (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone and pharmaceutically acceptable salts thereof are described as well as methods of their use, and a dose regimen of (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone, sodium salt to reduce the incidence of urothelial toxicity.

The invention discloses a fluorescent probe molecule for pH (potential of hydrogen) detection, which is 2-(4-methoxystyrene) quinoline-6-phenol. The invention further discloses a preparation method ofthe fluorescent probe molecule. The invention further discloses a fluorescent thin-film sensor of the fluorescent probe molecule for pH detection and a preparation method of the fluorescent thin-filmsensor. A glass matrix of the sensor is coated with the fluorescent probe molecule. The preparation method comprises the steps of putting the fluorescent probe molecule in a Nafion solution for uniform mixing to form a film casting liquid, spin-coating the film casting liquid onto the glass matrix, putting the glass matrix in a solvent evaporation chamber, heating to 100-120 DEG C under a high vacuum condition, holding the temperature for 0.5-12h, removing a solvent and obtaining the fluorescent thin-film sensor. The invention further discloses the application of the fluorescent probe molecule and the fluorescent thin-film sensor in detecting the pH value of a solution. A ratio-type fluorescent probe has two fluorescent emission peaks, and can be calibrated by two signal peaks of the fluorescent probe, and the detection accuracy is improved.

This present invention relates to (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides of general formula A. The invention also provides the synthesis of (Z)-3,4,5-trimethoxystyrylbenzenesulfonamides useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof.

Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

The invention relates to a preparation method of Ramage linker and mainly solves problems of long processes, complex post-treatment, much waste water, waste gas and solid waste, and high cost in a conventional synthetic method. The preparation method includes following steps: (A) carrying out a reaction to 2-carboxybenzaldehyde and m-methoxyphenylacetic acid to obtain an intermediate 2-(3-methoxylstyryl)benzoic acid, dissolving the intermediate with a solvent, performing hydrogenation reduction, and performing post-treatment crystallization to obtain a compound R-1; (B) carrying out a reaction to the R-1 with SOCl2 or POCl3 to obtain 2-methoxyl-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-one, performing negative-pressure evaporation to remove the SOCl2 or the POCl3, dissolving the 2-methoxyl-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-one in benzene, methylbenzene or 1,2-dichloroethane, performing a catalytic reaction with anhydrous AlCl3 and performing post-treatment crystallization to obtain a compound R-2; (C) carrying out a reaction to the R-2 with benzyl bromoacetate in DMF or an acetone / K2CO3 solution to obtain a compound R-3; (D) performing hydrogenation reduction to the R-3 to obtain a compound R-4; and (E) adding a catalyic amount of PTS to the R-4 in DMF and carrying out a reaction to the R-4 with Fmoc-NH2 to obtain the Ramage linker, which is an effective C-terminal linker in solid-phase synthesis.