369 results about "Live animal" patented technology

A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

A highly automated method and system for providing individual animal electronic identification, measurement and value based management of cattle in a large cattle feedlot. Through the use of (1) a computer system integrated with (2) automatic individual animal identification (3) multiple measurement and remeasurement systems with automatic data input and (4) a cattle handling and sorting system, animals are individually (a) identified and (b) measured by weight, external dimensions and characteristics of internal body tissue. With this information together with animal physiological characteristics and historical data, the computer system calculates the optimum (c) slaughter weight, (d) economic end point and (e) marketing date for shipment to a packing plant. After measurement, individual animals are (f) sorted by direction of the computer in response to calculations from the measurements. The computer system also calculates from individual animal data and other data (g) each animal's pro rata share of total feed intake for the animal's feed group. The computer system (h) stores individual animal measurement, performance and location data, which is used by management to (i) select animals for shipment from the feedlot for slaughter at the optimum time. Following an animal's shipment to a slaughter facility, its identification in the computer system is used to (j) correlate the live animal physical characteristics and performance data to the measured and evaluated carcass characteristics data obtained during the slaughter process and (k) build a data base to more accurately identify and measure value-based characteristics in subsequent animals produced and fed for more effective value-based selection and management of those animals.

Disclosed herein are synthetic anatomical models that are designed to enable simulated use testing by medical device compam'es, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of complexity that allows them to be substituted for either a live animal, an animal cadaver, or a human cadaver in the testing of these devices. These models are further characterized by a similarity of geometry, individual component physical properties, and component-to-component interfacial properties with the appropriate target tissue and anatomy.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and / or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and / or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and / or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

The present invention provides one kind of reagent for simultaneously detecting several kinds of small molecular compounds and its preparation process and usage. The preparation process includes the following steps: preparing coded microsphere reagent, and preparing one of the small molecular compound detecting antibody probes, including fluorescent quantum dot antibody probes, fluorescent quantum dot secondary antibody probes, fluorescent dye antibody probes and fluorescent dye secondary antibody probes. The method of detecting small molecular compounds with the antibody probe may be a direct antibody probe method or a indirect antibody probe method. The present invention may be used in detecting residual veterinary medicine, pesticide, banned drug, misused medicine and other small molecular compounds in food, agricultural product, living animal body and human body, and has the advantages of high sensitivity, high repeatability, etc.

The present invention relates to a kind of miniature needle array for medicine transmission, and features that the miniature needle in the array is non-planar solid miniature needle comprising a needle tip for piercing live animal skin, a needle body for increasing the pierced depth, and a base for stabilizing the array and preventing breaking and residue in the skin of miniature needle. The miniature needle array is changeable in the base number, the miniature needle number, the 3D structure of the needles, needle tip interval, needle tip height and the needle tip inclination for practical requirement. The miniature needle array is made through MEMS and polymer-MEMS combining process, in which only one mask is used for twice photo etching to form the needle tips and the needle bodies of the miniature needles. The present invention is used for vaccine and medicine transmission through micropores formed with the solidified hydrogel.

The invention belongs to the field of application of near-infrared laser, nuclear irradiation, electron and image rebuild in systematic biology and medicine. It is characterized in that high-specificity nuclear species and fluorescent probe are implanted in live animal to realize double mark of muscle deep layer or internal organ tumor cell. The emission signal of nuclear species is checked by sensitive electron-multiplier phototube in array copulation position of scintillation crystal; feeble fluorescent signal generated by visible light or infrared agitation is checked by high quantum yield CCD camera. The two checking systems are orthogonally arranged in the same surface, the live nuclear species and fluorescent signal can be checked simultaneously through rotary image cavity, and double module three dimensional tomography image of small animal can be rebuilt with software algorism. The invention is characterized by multi-image forming modules, abundant information and simple operation.

Preparations of novel molecular transporter compositions and their use for transporting bioactive substances into cells in living animals are disclosed. To afford in vivo delivery, the composition is covalently linked to the bioactive substance and the resultant composite structure is introduced into the subject. The transporter composition includes multiple guanidine moieties on a dendrimeric scaffold having a triazine core.

The devices and methods generally relate to vibratable sensors for measuring ambient fluid pressure, in particular implantable sensors. The devices and methods are particularly well-suited to implantation within the body of a living animal or human to monitor physiological conditions, such as portal and / or hepatic venous blood pressure, and allow frequent, remote interrogation of venous pressure using the resonance frequency of an implanted sensor. The sensor devices are relatively small compared to conventional devices for measuring fluid pressure and can be implanted in the porto-hepatic venous system, whereas conventional devices are too large. The small size of the device is accomplished by using a thick sensor membrane, compared to conventional devices, and by limiting the size of additional elements of the device relative to the size of the sensor membrane. The thicker sensor member also obviates the need for multiple sensor arrays and maintains the accuracy and robustness of the sensor device. A data capture, processing, and display system provides a pressure measurement reading, and is particularly well-suited for detecting portal hypertension in patients with liver disorders.

The invention provides a method for predicting growth efficiency of an animal by using infrared thermography by generating a predictive model, comprising selecting a sample population from a group of animals; scanning each animal to obtain a thermographic image represented as an array of pixels providing temperature data; calculating a value of a statistical measure of the temperature data (input variable); calculating a value of a measure of growth efficiency (output variable); and determining a relationship between the input and output variables to generate a predictive model. The predictive model is then used to predict growth efficiency in an animal from the same group but not in the sample population by scanning the animal to obtain a thermographic image; calculating a value of a statistical measure of the temperature data (input variable); and solving the predictive model to provide the value of the growth efficiency of the animal.

A travel carrier suitable for use in transporting a live animal via a mode of transportation, comprises an enclosure of suitable size and shape for a live animal; a power source; a video camera connected to the power source and arranged in the enclosure for capturing a video image of the animal in the enclosure; and an RF transmitter. The transmitter, which is operatively connected to the video camera, transmits a signal representing a video image of the animal to a remote receiver. The carrier may also comprise a GPS unit disposed on or in the enclosure, which is operatively connected to a transmitter, for transmitting a signal representing the location of the carrier to the remote receiver.

The present invention relates generally to a method and devices for the detection of target objects, such as landmines, using the odor characteristics which may be associated with the target objects as a way of detecting their presence. The invention includes devices used to carry out a method of training live animals, such as rats, to seek out the target objects in the field, or to localize, unearth, and mark the location thereof.

A device includes light sources, electromagnetic field generators, and vibration components to apply a variety of treatment regimens to a living animal organism, including a human person or a body part of a person. The light and electromagnetic therapy are applied at frequencies which have physiological effects, and which can be combined to induce lipolysis, stimulate muscle, and achieve other effects. Feedback is used to dynamically adjust the intensity, duration, and other parameters of the light, electromagnetic, and vibration treatment modalities.

A device and a method are described for finding the location of a bone surface in patients or living animals by using a thin probe equipped with bone contacting detection functionality for a minimally invasive procedure.

The present invention relates the use photosensitizers to inactivate bacterial spores of bacterial species including Bacillus anthracis. Methods of the present invention are useful in the decontamination and treatment of living animals and in the decontamination of inanimate objects and substances.

The invention relates to a multi-mode non-linear optical microscopy imaging method and device. The multi-mode non-linear optical microscopy imaging device mainly comprises a laser system, an optical scanning microscope and a non-linear optical signal detecting and acquiring system. The multi-mode non-linear optical microscopy imaging device can work in a single-laser-beam mode and a dual-laser-beam mode and can realize multi-mode non-linear optical microscopy imaging such as two-photon excited Fluorescence (TPEF) imaging, multiphoton high-order harmonic (such as second harmonic generation SHG, and third harmonic generation THG) scattering imaging, coherent Raman scattering (such as anti-Stokes CARS) microscopy imaging) on isolated biological tissues and living cells, so that various non-linear specific optical signals of biological tissue samples can be obtained in situ, so that the important basis is provided for the optical diagnosis and deep analysis of the samples. Besides, a reflection measurement manner disclosed by the invention can be further directly applied to the acquiring of various non-linear specific optical signals of live animals and the microscopy imaging.

An intelligent automatic peritoneal dialysis device injects a dialysate accommodated in a dialysate container into a live animal via an input duct, elicits a waste liquid from the animal via an output duct, and concentrates the waste liquid in a waste liquid container. A flow direction control valve controls the flow direction of the dialysate and the waste liquid during the overall peritoneal dialysis treatment process.

A system of accurately predicting birth of large-sized livestock such as cows sufficiently before the time of making delivery preparations and attending delivery is provided. Vaginal temperatures of livestock such as cows measured by temperature sensor / transmission modules 100 inserted in the vagina of the livestock are transmitted wirelessly, received by a reception module 200, and sent to a monitor center 350 from a station 310 connected to the Internet 300 via a wireless LAN or a wired LAN. The monitoring center 350 is capable of storing the transmitted vaginal temperature data of each livestock, predicting birth timings from the stored vaginal temperature data, and reporting the birth timings by email or the like to a feeder's cellular phone 320 or a cellular phone 340 of an affiliated veterinarian.

The invention relates to a method and a device for weighting a living animal. The method for weighting the living animal comprises the following steps: sampling weight information of the living animal by use of an electronic scale according to a preset sampling frequency; acquiring weight information sampled within a preset time interval by use of the electronic scale; taking the weight information sampled within a preset time interval as a set of basic data for counting the weight under the condition that the electronic scale confirms that the stability of the weight information sampled within a preset time interval meets the demand on the preset stability; and calculating the weight of the living animal by use of the electronic scale according to preset sets of basic data. The technicalscheme of the invention can be used for ensuring the weighting error of the living animal to be no more than 0.1%. Compared with the weighting error, namely 1%, of the living animal in the prior art,the weighting error of the living animal is increased by an order of magnitude, so that the method for weighting the living animal can be used for efficiently improving the accuracy of weighting the living animal.

A system that compares, ranks, sorts and grades animals or carcasses into groups of like kinds according to previously determined predicted maximum values. For live animals, the system uses magnetic resonance imaging (MRI) on a single occasion to evaluate the animal and determine a number of days the animal must be fed to reach a maximum value. For carcasses, the system evaluates the carcass to grade the quality and quantity of meat the carcass will provide. The system also combines MRI imaging with a three-dimensional system to refine the number of days remaining for the animal to reach a maximum value, and the system, when used in a feedlot, will direct the animal to a feed pen based on the number of days remaining for the animal to reach maximum value.

In vivo imaging may be used to assess a condition (e.g., a state of glaucoma or a state of ocular hypertension) of an eye of a living animal. A dye may be intravenously injected into the living animal. The dye may bind to amyloid in the nervous system of the animal. Images may be taken of a retina, an optic nerve head, an optic nerve, the lateral geniculate nucleus, and / or the visual cortex. Images may be taken using methods such as fluorescent angiography, magnetic resonance imaging, computed tomography, positron emission tomography, and / or single photon emission computed tomography. The condition of the eye and / or retinal ganglion cells in the eye may be assessed from one or more of the images. The condition of the eye may be assessed based on the presence of amyloid in one or more of the images.

Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and / or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and / or in vivo testing.

Disclosed herein are synthetic anatomical models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of complexity that allows them to be substituted for either a live animal, an animal cadaver, or a human cadaver in the testing of these devices. These models are further characterized by a similarity of geometry, individual component physical properties, and component-to-component interfacial properties with the appropriate target tissue and anatomy.