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Miniature needle array for medicine transmission and its making process

A technology for microneedle arrays and manufacturing methods, which is applied in the direction of microneedles, techniques for producing decorative surface effects, separation methods, etc., which can solve the problems of needles without sharp ends, complexity, and high requirements for the production process of microneedle arrays, and achieve production costs. Low, good drug delivery effect

Active Publication Date: 2007-06-27
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, polymers can only be fabricated into heteroplanar microneedles using a combination of micromolds and photolithographic patterning
In 2003, Moon et al. used inclined LIGA technology (including X-ray deep technology, micro-electroforming and micro-forming technology) to produce different-plane hollow PMMA microneedles, which can be used for painless injection and blood sample extraction. However, the fabrication process of the microneedle array is very demanding.
Tsinghua University Ran Liu et al. (Liu R, Wang X H, Zhou Z Y, et al. Microneedles array for fluid extraction and drug delivery, 2003 International symposium on microchatronics and humanscience, NewYork, USA, 2003, 239-244) used UV-LIGA technology ( Including ultraviolet light exposure technology, micro-electroforming and micro-forming technology) successfully produced hollow SU-8 microneedles on glass substrates, which can be bonded to glass sheets and polymers to form microfluidic devices. Drug delivery, but the needles of this microneedle do not have a tip, so they cannot pierce the skin of living animals smoothly, making it difficult to achieve transdermal therapy or drug delivery
Korean Park and Yoon et al. (Park J H, Davis S, Yoon Y K, et al.Micromachined Biodegradable Microstructures, Proc IEEE Conf.MEMS, Kyoto, Japan, 2003, 371-374) made heteroplanar solid polymer microneedles by micromold method , the microneedle tip has an obvious inclination angle, can pierce the epidermis multiple times without breaking, and can transport drugs or proteins by diffusion or degradation, but the microneedle tip manufacturing process requires deep reactive plasma etching, which is relatively complicated

Method used

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  • Miniature needle array for medicine transmission and its making process
  • Miniature needle array for medicine transmission and its making process
  • Miniature needle array for medicine transmission and its making process

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Embodiment 10

[0054] The making of embodiment 10×10 microneedle array

[0055] The following parameters are considered when designing the microneedle array: the size of the main structure, the three-dimensional structure size of the microneedle structure, the thickness of the surface modification material, and so on. The designed pattern is made into a mask (as shown in Figure 2), which can be used as a mask for oxide layer etching and SU-8 photolithography at the same time, so as to be transferred to silicon wafers containing oxide layers and SU-8 photolithography. -8 on substrate. When making the layout, you can change the base area of ​​the microneedle array, the number of microneedles, the three-dimensional structure of the needle, the distance between the needle tips and the height of the needle tip according to the actual application needs: change the unit area of ​​the microneedle array on the mask according to the toughness and thickness of the skin that need to be penetrated , so ...

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Abstract

The present invention relates to a kind of miniature needle array for medicine transmission, and features that the miniature needle in the array is non-planar solid miniature needle comprising a needle tip for piercing live animal skin, a needle body for increasing the pierced depth, and a base for stabilizing the array and preventing breaking and residue in the skin of miniature needle. The miniature needle array is changeable in the base number, the miniature needle number, the 3D structure of the needles, needle tip interval, needle tip height and the needle tip inclination for practical requirement. The miniature needle array is made through MEMS and polymer-MEMS combining process, in which only one mask is used for twice photo etching to form the needle tips and the needle bodies of the miniature needles. The present invention is used for vaccine and medicine transmission through micropores formed with the solidified hydrogel.

Description

technical field [0001] The invention relates to a microneedle array and a manufacturing method thereof, in particular to a microneedle array that can be used for transdermal treatment or drug delivery, and a manufacturing method of the microneedle array. Background technique [0002] Nowadays, microelectronics technology is widely used in biomedical engineering. In order to efficiently and non-destructively deliver drug solutions to living organisms, microneedle technology has emerged as the times require. It is very difficult to manufacture needles with a diameter of less than 300 μm by traditional mechanical manufacturing methods, but micro-electromechanical process technology (MEMS) can manufacture micron-scale microneedles with complex structures. The microneedle structure is similar to the needle of a traditional syringe. The needle tip is symmetrically conical or asymmetrically inclined. From the internal structure, it can be divided into hollow and solid microneedles...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/32A61M5/158A61B5/15H01L21/00B81B7/00B81B1/00B81C1/00
CPCA61M37/0015A61M2037/0053
Inventor 许宝建金庆辉赵建龙
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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