The invention discloses a manganese nickel aluminum cobalt base NTC thermistor material and a preparation method thereof, and belongs to the technical field of electronic information functional materials and devices. The manganese nickel aluminum cobalt base NTC thermistor material is prepared from the main components of oxide of manganese, nickel, aluminum and cobalt, and semi-conducting doping elements of copper and antimony, a solid reaction process is adopted to prepare, and preparation is conducted through processes such as ball-milling, drying, pre-sintering, secondary ball-milling, drying, and crushing and filtering. According to the manganese nickel aluminum cobalt base NTC thermistor material and the preparation method thereof, the thermistor material has the characteristics thatthe stability is good, the sintering temperature is low, and electrical characteristics such as resistance values, material constant and resistance temperature coefficient are controllable; and the preparation method can be used for manufacturing NTC thermistors and temperature sensors in the modern electronic communication technology, and applied to occasions such as temperature measuring, temperature controlling, compensating, voltage stabilization, remote control, flow rate measuring and time delay.