123 results about "Drug Abstinence" patented technology

The invention discloses an electrocerebral and near-infrared combined drug addiction assessment method. A PC host is responsible for operation of all module software programs, and an experimental paradigm module is composed of an Eprime experimental paradigm program, designed for patients abstained from drugs, induces activation of neurons in different brain regions of a brain through a specific stimulated picture presentation pattern to generate relevant brain activity information, and transmits the relevant brain activity information to an electrocerebral collection module and a near-infrared collection module; the electrocerebral collection module collects electrocerebral signals in the brain activity information under the effect of the Eprime experimental paradigm program through TCP / IP; the near-infrared collection module collects oxyhemoglobin signals and deoxyhemoglobin signals in the brain activity information under the effect of the Eprime experimental paradigm program; and anassessment algorithm module identifies and assesses the severity degree of drug addiction of the patients abstained from the drugs by adopting a support vector machine classifier through informationobtained by the electrocerebral collection module and the near-infrared collection module.

The invention belongs to the fields of biochemistry and molecular biology, relates to an alpha-conotoxin peptide, and a medical composition, a preparation method and a purpose thereof, also relates to a propeptide of the conotoxin peptide, a nucleic acid construct, an expression vector, a transformed cell and a fusion protein, and also relates to a method for blocking acetylcholine receptors and a pharmaceutical purpose of the conotoxin peptide. The alpha-conotoxin peptide can specifically block the acetylcholine receptors (nAChRs) (such as alpha3beta2 nAChR), has high analgesic activity and addiction withdrawal activity and has a good application prospect in the aspects of preparing analgesics, smoking cessation or drug treatment medicines and the like.

The invention discloses a cigarette for detoxification, wherein, tobacco shreds are composed of tobacco and lotus leaves absorbing ingredients of a detoxification drug, and the tobacco accounts for 10 to 50 percent of the total mass of the tobacco shreds. The invention further discloses a preparation method of the cigarette for detoxification. The cigarette for detoxification of the invention can allow drug aerosol to be absorbed by the human inner mucosa in the ionic state with the help of a smoking mode of the cigarette by the people, thus having significant efficacy, rapid effectiveness and facilitating the fine adjustment and control of the dose of the psychotropic drug; furthermore, the preparation method is simple and easy to realize, thus having broad market prospect.

The invention discloses an intelligent drug detoxification management method using rehabilitation training. The method comprises the following steps: the drug detoxification personnel identity information is inputted into a management platform; physical examination is performed on all the drug detoxification personnel and the examination report information is inputted into the management platform;the personnel are divided into the special group and the general group according to the physical examination result; the rehabilitation training courses for the corresponding diseases are allocated to the special group; the further physique test is performed on the normal patients; the management platform allocates regular group rehabilitation training courses and individual targeted rehabilitation training courses to the general group according to the physique test result; the drug detoxification personnel obtain the rehabilitation training courses; the bracelet collects exercise status datainformation; and alarming is performed if the amount of exercise exceeds the preset value of the bracelet. The management platform is applied to formulate the targeted training plan and the rehabilitation scheme for the drug detoxification personnel, and the exercise data and the physical condition data of the drug detoxification personnel are collected through the bracelet so as to achieve intelligent management.

The invention provides morphinone quaternary ammonium salt derivatives which are prepared through the following steps: obtaining morphinone derivatives from morphine as the starting material through demethylation, oxidation, reduction, condensation and other chemical reactions; and obtaining the morphinone quaternary ammonium salt derivatives from the morphinone derivative through the reaction with halocarbon. The preparation method of the invention has the characteristics of few technological steps, low production cost, simple operation, stable quality and the like. The compounds provided by the invention have obvious contraction effect on the morphine-dependent guinea pig ilea, thereby promoting the intestinal peristalsis, the compounds are applicable to the preparation of drugs for curing constipation and intestinal obstruction; and the compounds provided by the invention further have obvious inhibiting effect on the conditioned place preference (CPP) of morphine-induced rats to the drug-paired compartment, therefore, the compounds can be used for preparing anti-relapsing drugs and effectively reducing the relapse rate, and the invention is favorable for the all-round promotion of rehabilitation and anti-relapsing work.

A Chinese medicine in the form of honeyed pill for dropping drug is prepared from 39 Chinese-medicinal materials including notoginseng, astragalus root, corydalis tuber, eagle wood, ginseng, etc through classifying, pulverizing, sieving, mixing, adding honey and distilled water, stirring and pilling. Its advantages are high and stable curative effect, short course of treatment, low recurrence rate and low toxic by-effect.

The present invention is asafetida extract and its pharmaceutical use, and aims at eliminating offensive odor of asafetida and providing one new use. The asafetida extract contains alpha-terpinene, 2-borneol, terpine tetraol, D-fenchol, pinocarveol, etc. and is extracted via conventional process. The asafetida extract is used in preparing drug addiction stopping medicine, and the medicine may be injection, capsule, tablet or granule.

The present invention relates to a tetrodotoxin preparation used for drugs abstinence and analgesia. The preparation comprises small dose of tetrodotoxin that is taken as active ingredient of medicine and cosolvent or allowable supportting agent in pharmacy. The cosolvent is amino acid. In the present invention, the amino acid is taken as the cosolvent, which not only can act as the cosolvent for increasing solubility of the tetrodotoxin in water, but also can form highly water-soluble salting liquid with the tetrodotoxin. The tetrodotoxin used in the present invention is prepared by adopting the specific method of the present invention. The purity of the prepared tetrodotoxin is as high as 98 percent with high yield. The preparation formed by the tetrodotoxin prepared by adopting the method provided in the present invention and amino acid is not only good in water solubility, but also good in stability, safe, reliable, stable in quality. The preparation does not need to be preserved in the refrigerator at specific temperature. The preparation can be preserved for more than 2 years at room temperature, thus greatly saving storage and transportation cost and providing convenience for use in medical treatment. The cure effect is evident, and in particular when applied to physiologic de-toxin, the tetrodotoxin preparation has a cure rate reaching 100 percent.

The present invention discloses a medicine composition for stopping pain and / or stopping drugs, it contains opium receptor complete excitant or opium receptor complete excitant with analgetic effective dose and rotundine with analgetic effective dose. Said medicine composition has strong analgetic effect and its addiction side effect is less.

The invention discloses a police conversation speech recognition method and system based on big data. The method comprises the steps of completing identity provisioning of a talker and a person to betalked and parameter setting of audio collecting equipment, completing control of the audio collecting equipment, and automatically generating a talking file catalogue; showing the recognition text contents of talking speech displayed in real time by a talking interface display window, and saving talking speech files and text files; analyzing the talking speech through big data, designing a mentalstate evaluation list, analyzing the mental state index of a talking target, and generating a big data analysis report; and enabling the talking speech files and the text files to be related to the inner part of a judicial system, and completing sharing of the talking speech files and the text files. According to the police conversation speech recognition method and system, the working strength of working police is alleviated, the working efficiency is improved, through the big data analysis method, the mental state of drug addicts under control to give up their habits is analyzed, and support can be provided for increment of the education level of the drug addicts under control to give up their habits.

A medicinal cigarette for dropping drug is prepared from 13 Chinese-medicinal materials including honeysuckle flower, red sage root, Chinese angelica root, astragalus root, etc. Its advantages are high curative effect, quickly taking its effect and no addiction.

The invention relates to a drug rehabilitation preparation and method for preparation, wherein the preparation comprises predetermined amount of tetrodontoxin monomer as the main effective composition, right amount of auxiliary material carrier, function modifier and tetrodontoxin derivative as the stabilizer, the acidic dissolvent carrier is selected from acetic acid / sodium acetate, or citric acid / sodium citrate, or citric acid / disodium hydrogen phosphate, the function modifier is at least one selected from trichlorbutanolum, benzoic alcohol and lignocaine hydrochloride.

The invention discloses a device and a method for nervous system data acquisition of drug addicts. The device comprises a flexible pressure sensor module, a gait information acquisition module, a display module, a voice module, a drug addiction induction module, a drug abstinence person information management system, a gait test system and a gait analysis system; the output of a flexible pressuresensor and the output of the gait information acquisition module are connected with the gait test system, the gait test system, the control voice module, the display module and the drug addiction induction module are used for executing corresponding instructions, collecting relevant data for preprocessing, and acquired data is obtained.

The invention relates to the technical field of traditional Chinese medicine formulas and preparation methods thereof, and particularly relates to a traditional Chinese medicine formula for stopping novel drug addiction and carrying out rehabilitation treatment on sequelae and a preparation method thereof. The traditional Chinese medicine formula comprises the following components in parts by weight: 20-45 parts of carambola flowers, 30-35 parts of salvia miltiorrhiza, 20-35 parts of polygala amflra, 30-45 parts of rhizoma acori graminei, 9-18 parts of gardenia jasminoides, 15-30 parts of fructus schizandrae, 25-50 parts of dried tangerine or orange peel, 40-50 parts of herba violae, 30-35 parts of radix semiaquilegiae, 40-50 parts of dandelion roots, 30-35 parts of Chinese milkwort, 20-30 parts of semen ziziphi spinosae, 20-30 parts of feather cockscomb seeds, 25-30 parts of mother-of-pearl, 30-35 parts of snakegourd seeds, 20-30 parts of pinellia ternate, and 10-20 parts of fritillaria cirrhosa. The traditional Chinese medicine formula disclosed by the invention is good in curative effect, and fills up a gap in stopping domestic novel drug addiction and carrying out rehabilitation treatment on sequelae.

The present invention provides a novel α-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The α-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as α3β2 nAChRs, α6 / α3β2β3 nAChR or α3β4 nAChR or α6 / α3β4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

The invention belongs to the field of biochemistry and molecular biology, and relates to an alpha-conotoxin peptide TxIC / Txd1 and a medicinal composition and application thereof. The alpha-conotoxin peptide can specifically block an acetyl choline receptor (nAChRs, such as alpha3beta4 nAChR (nicotinic acetylcholine receptor)), has curative activity to habituation, neuralgia, Parkinsonism, dementia, schizophrenia, depression, cancers, fear and the like, and has a good application prospect on the aspect of preparation of smoking cessation, drug treatment and pain relieving medicaments, medicaments relevant to the treatment of mental diseases and cancers, neuroscience tool medicaments and the like.

The invention discloses a quick-acting drug abstinence de-addiction pure Chinese medicinal preparation and a preparation method thereof. The quick-acting drug abstinence de-addiction pure Chinese medicinal preparation consists of two parts, namely a drug abstinence, toxin expulsion and detoxication Chinese medicinal preparation A and a drug abstinence, body resistance strengthening and mind tranquilizing Chinese medicinal preparation B, and belongs to the field of traditional Chinese medicines. The quick-acting drug abstinence de-addiction pure Chinese medicinal preparation is preferably prepared by refining raw materials such as cordyceps sinensis, American ginseng, astragalus, Chinese angelica, Japanese milkwort herb, liquoric root, baical skullcap root, golden thread, yanhusuo, medicinal evodia fruit, Chinese date, honeysuckle flower, spina date seed, thinleaf milkwort root-bark and the like. The quick-acting drug abstinence de-addiction pure Chinese medicinal preparation has the effects of supporting healthy energy, expelling drug toxicity, abstaining drugs, promoting flow of Qi and blood circulation, dispersing cold to ease pain, calming the heart, tranquilizing the mind and the like. The preparation has reasonable compatibility of the medicines, has a simple preparation process, is convenient to take, has quick response and has no adverse side effect or addiction, the patient is quickly recovered and does not need injection, transfusion or care, and the preparation is one of the most effective medicines for drug abstinence at present.

The invention discloses a traditional Chinese medicine compound for drug addiction treatment. The ingredients of the traditional Chinese medicine compound are selected from natural medicinal materials, and the traditional Chinese medicine compound belongs to the field of medicines. The traditional Chinese medicine compound is prepared from 15 traditional Chinese medicines, including coptis chinensis, scutellaria baicalensis, jasmine, radix curcumae, corydalis tuber, angelica sinensis, bezoar, radix paeoniae alba, polygala tenuifolia, spina date seeds, ginseng, astragalus membranaceus, poria cocos, radix aconiti carmichaeli and liquorice. The traditional Chinese medicine compound for drug addiction treatment, disclosed by the invention, is wider in application scope, lower in toxicity and better in curative effect; the traditional Chinese medicine compound can thoroughly eliminate vivotoxin, is free from toxic or side effect and can not cause physiological or psychological dependence; and after a patient takes the traditional Chinese medicine compound for treating drug addiction, the patient has a strong disgusting feel if the patient contacts with the drug again, so that the relapsing phenomenon can be overcome.

The invention relates to the field of medicines and in particular relates to a drug addiction treatment pure traditional Chinese medicine preparation and a preparation method thereof. The method comprises the following steps: preparing the following materials in parts by weight: 150 parts of American ginseng, 100 parts of white paeony root, 200 parts of fructus cormi, 100 parts of herba cistanche, 100 parts of angelica sinensis, 150 parts of fructus psoraleae, 200 parts of prepared rehmannia root, 150 parts of gorgon fruit, 80 parts of cornu cervi degelatinatum, 100 parts of eucommia ulmoides, 5 parts of venenum bufonis, 100 parts of immature bitter orange, 100 parts of scutellaria baicalensis, 150 parts of lophatherum gracile, 100 parts of rheum officinale, 5 parts of calculus bovis factitius, 100 parts of aconite, 50 parts of henbane, 100 parts of glabrous sarcandra herb, 30 parts of rhizoma corydalis, 90 parts of corydalis tuber, 200 parts of liquorice and 150 parts of hindu datura flower. The preparation method comprises the following steps: extracting the raw materials, wherein an extraction solvent is ethanol; and granulating the extract. The drug addiction treatment pure traditional Chinese medicine preparation has the effects of treating drug addiction and easing pain, is a traditional Chinese medicine preparation and is small in toxic and side effects.

The invention provides a pharmaceutical composition for stopping drug addiction, its formulation, preparing process, use and quality standard, wherein the composition is prepared from 16 kinds of traditional Chinese medicinal herbs including musk and panax ginseng. The composition has the advantages of quick effect in drug rehabilitation.

Systems and methods of an electronic cessation system. The system can include a mobile platform and a hand-held inhalation device including a flow sensor, aerosol sensing density and temperature sensors, a first, second, and third aerosolizer drivers, a rescue button, a power source, and a controller circuit comprising a hardware controller coupled to the power source, the sensors, the first, second, and third aerosolizer drivers, and the rescue button. The hardware controller is configured to perform a smoking cessation program that includes receiving input signals from the sensors, and the rescue button, and individually controlling the three aerosolizer drivers to provide aerosolizer generation signals to control a first, second and third aerosolizers of the aerosolizer pod to dynamically generate individually tailored aerosol mixtures from three substances in the aerosolizer pod based at least on the received input signals and the smoking cessation program information.

The invention discloses a Chinese medicinal drug addiction stopping and three-hyper lowering capsule, which is prepared by cleaning, drying, smashing, uniformly mixing and loading 39 types of Chinese medicines such as pseudo-ginseng root, astragalus, corydalis tuber, Chinese eaglewood, and ginseng into a capsule. The Chinese medicinal drug addiction stopping and three-hyper lowering capsule has the advantages of stable curative effect, short treatment course, small toxic and side effects and low relapse rate. The capsule also has an immunity enhancing function on a patient suffering from 'three-hyper (hypertension, hyperlipemia and hyperglycemia)' in cardiovascular system diseases, and a rehabilitation effect is achieved.

The invention discloses a drug addiction degree detection method, a computer system is used for drug addiction degree detection, and an adopted detection system is composed of a behavioristics module,a drug addiction stimulation module, a data acquisition module, a CNN model establishment module, a CNN classification module and a result evaluation module. The method comprises the following operation steps: 1) collecting behavioral indexes; 2) stimulating the response of drug addicts to drugs; 3) collecting near-infrared data; and 4) establishing a CNN model. 5) performing CNN classification;and 6) evaluating a result. The method solves the problem that the addiction degree of the drug addiction personnel can only be defined according to artificial subjective factors. According to the method, the artificial intelligence method is used for classifying physiological data of mild, moderate and severe drug addiction personnel, and the average accuracy is 75%. According to the method, drugaddiction degree definition is more objective and standardized, and drug rehabilitation and rehabilitation trend is more scientific, reasonable and humanized.

The invention relates to the technical field of big data analysis, in particular to a risk assessment method and a system for forcibly isolating drug addicts. The method comprises the steps of forminga forced isolation drug addiction treatment personnel risk assessment label by drug addiction treatment management personnel for the sample data of the forced isolation drug addiction treatment personnel and the risk assessment data screened by the user portrait label; inputting the user portrait label of each forced isolation drug abstinence person in the training set and the user portrait labelof each forced isolation drug abstinence person in the test set into a LightGBM classification model; and when the classification accuracy and the recall rate meet set values, obtaining a standard LightGBM classification model, and obtaining a risk assessment result of the to-be-assessed forced isolation drug abstinence person through the standard LightGBM classification model. The method can effectively predict and prevent the occurrence of abnormal behaviors of forced isolation drug addicts, and provides decision support for the implementation of supervision in the later period.

The invention relates to an external-use Chinese medicament for fighting drugs, which comprises a main medicine and an adjuvant; the raw materials of the main medicine comprise the following crude medicines according to parts by weight: 1pbw to 15pbw of scorpion, 8pbw to 40pbw of radix aconiti agrestis, 20pbw to 50pbw of aconitum Chinese paxton, 25pbw to 40pbw of gecko, 15pbw to 30pbw of nux vomica, 40pbw to 80pbw of bloodsuckers, 35pbw to 90pbw of Chinese gall, 35pbw to 90pbw of radices euphorbiae kansui liou, 8pbw to 30pbw of brimstone, 3pbw to 25pbw of cantharis, 2pbw to 8pbw of borneol (borneolum syntheticum), 1pbw to 5pbw of camphor, 10pbw to 90pbw of dung beetles, 4pbw to 28pbw of musk and 250pbw to 500pbw of Sailong bone; the raw materials of the adjuvant comprise 15pbw to 20pbw of flos daturae, 8pbw to 12pbw of liquorice, 15pbw to 20pbw of safflower and 300pbw to 800pbw of Shanxi mature vinegar. The invention also relates to a preparation method of the external-use Chinese medicament. The external-use Chinese medicament is applied to the projection position of encephalic conarium inside in the occipital skin of a patient, utilizes the principles of using poison as an antidote to poison and removing toxin by normalizing meridian to help the patient withdraw addicting to narcotic drugs, such as heroin, methamphetamine, marijuana or dancing outreach, and the like.

The invention relates to a drug addiction treatment medicine supply and recovery device, which comprises an alcohol detection system, a medicine supply system and a drinking utensil recovery system. The alcohol detection system performs alcohol detection on a medicine user through an alcohol detection sensor. The medicine supply system comprises a cup lifting control module, a cup falling controlmodule and a straw control module. The drinking utensil recovery system comprises a cup body recovery module and a straw recovery module. The medicine supply system sends a drinking utensil to a liquid medicine and drinking water supply port, the alcohol detection system detects alcohol of a person entering the range of the device, the liquid medicine and the drinking water are sequentially addedinto the drinking utensil after the person passes alcohol detection, and the drinking utensil recovery system recovers the used drinking utensil through the drinking utensil recovery system after thedrug user finishes drug taking. According to the device, the steps for providing a drug addiction treatment medicine are greatly simplified, a large amount of medicine supply cost is saved, and the device is high in practicability and safety performance and suitable for wide popularization.

The present invention provides a use of a lannaconitine compound to treat psychological dependence of addictive substances. Particularly, the disclosed lannaconitine compound or pharmaceutically acceptable salts thereof are used for (a) prevention and / or treatment of psychological dependence of addictive substances; (b) reduce psychological dependence drug addiction of addictive drugs; and / or (c)reduce probability of relapse (or reuse) of the addictive substances in subjects who have successfully detoxified. Experiments show that the lannaconitine compound can effectively treat the psychological dependence of morphine, alcohol and other addictive substances, reduce chance of the relapse of the addictive substances by the detoxified subjects and help the detoxified subjects completely getrid of addiction.

The invention discloses application of a GCS inhibitor in preparation of a medicine for treating cocaine addiction, and belongs to the field of drug rehabilitation medicines. Experiments prove that the GCS inhibitor can specifically reduce the content of glucosylceramide sphingolipid in the nucleus-isolated brain region, reduce the dendritic branch number and the dendritic spine density, and effectively inhibit the behavioral effects (behavioral sensitization, reward effect and autonomous administration behavioral effect) of cocaine on mice. The GCS inhibitor is used for preparing the medicine for treating cocaine addiction, and has a good application prospect.

The invention discloses a non-contact drug addict monitoring method and system based on IPPG. The non-contact drug addict monitoring method based on IPPG comprises a method for systematically detecting drug addiction persons in the supervision process from drug abstinence starting to dynamic management and control release and a method for evaluating the heart addiction of detoxified persons in therehabilitation stage, and multiple persons can be detected and evaluated at the same time. The invention further provides a non-contact drug addict monitoring system based on the IPPG. The system mainly comprises a video image acquisition module, a face recognition module, an IPPG signal extraction module, a physiological data acquisition module, an analysis and judgment module, a data model construction module, a relaxation training module, a video playing module, an archiving query module and a drug addict management module. The method and system disclosed by the invention have the characteristics of economy, convenience, high detection efficiency and the like. The system is simple in structure and convenient to use, infection hidden danger caused by contact type sampling or detection can be effectively avoided, the system is suitable for the whole-link drug addict supervision process from drug abstinence starting to dynamic management and control relieving, effective reference bases are provided for whole-link drug addict supervision, meanwhile, a systematic drug addict physiological data file can be established, and a data model is continuously and automatically perfected.

The invention discloses an LED (light emitting diode) multi-path irradiating drug detoxification apparatus, and belongs to the field of optical medical equipment. The LED multi-path irradiating drug detoxification apparatus transfers the comprehensive therapy effect of the present mature technology on the human body to a detoxification manner, adopts a high-brightness LED light source to carry out multi acupuncture point irradiation simulation to cause polypeptide substance 'endorphin' similar to morphine inherent in the brain to be weakened and enhance the self drug resistance, combines LED capillary external irradiation to replace or partially replace the pure drug detoxification, has the obvious advantages that drug abstainers are easy to accept, the detoxification is convenient, no side effects is caused, and the cost is low, not only stably detoxicates, but also enhances the immunity, reduces and prevent the relapse. Compared with a traditional therapeutic apparatus adopting a laser light source, the drug detoxification apparatus has a simple structure, is rich in therapy wave band, adjustable in irradiation power, wider in application range as compared with a traditional laser therapy method, is higher in flexibility, and lower in cost.