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307 results about "Carboxysome" patented technology
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Carboxysomes are bacterial compartments consisting of polyhedral protein shells filled with the enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) -the predominant enzyme in carbon fixation and the rate limiting enzyme in the Calvin Cycle-and a carbonic anhydrase. Carboxysomes are thought to have evolved as a consequence of the increase in oxygen concentration in the ancient atmosphere; this is because oxygen is a competing substrate to carbon dioxide in the RuBisCO reaction. To overcome the inefficiency of RuBisCO, carboxysomes concentrate carbon dioxide inside the shell by means of co-localized carbonic anhydrase activity, which produces carbon dioxide from the bicarbonate that diffuses into the carboxysome. The resulting production of carbon dioxide near RuBisCO decreases the proportion of ribulose-1,5-bisphosphate oxygenation and thereby avoids costly photorespiratory reactions. The surrounding shell provides a barrier to carbon dioxide loss, helping to increase its concentration around RuBisCO. The carboxysome is an essential part of the carbon dioxide-concentrating mechanism (CCM).
Acc inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:NIMBUS DISCOVERY INC +1
Simultaneous anaerobic production of isoamyl acetate and succinic acid
In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in order to maintain the proper redox balance between NADH and NAD+. The method is exemplified with null mutations in ldhA, adhE, ackA-pta and overexpression of pyruvate carboxylase and alcohol acetyltransferase. This strain produces higher levels of both isoamyl acetate and succinate.
Owner:RICE UNIV
Simultaneous anaerobic production of isoamyl acetate and succinic acid
InactiveUS20060141594A1Maximizing isoamyl acetate productionEasy to separateBacteriaTransferasesSuccinic acidPyruvate synthesis
In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in order to maintain the proper redox balance between NADH and NAD+. The method is exemplified with null mutations in ldhA, adhE, ackA-pta and overexpression of pyruvate carboxylase and alcohol acetyltransferase. This strain produces higher levels of both isoamyl acetate and succinate.
Owner:RICE UNIV
N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
Owner:PFIZER INC
Nucleic acid segments encoding wheat acetyl-CoA carboxylase
InactiveUS6306636B1Reduce the amount requiredAlter fatty acid biosynthesisSugar derivativesBacteriaCarboxysomePolynucleotide
The present invention provides isolated and purified polynucleotides that encode plant polypeptides that participate in the carboxylation of acetyl-CoA. Also provided are methods for identifying such nucleic acid segments and polypeptides. Processes for altering acetyl-CoA carboxylation, increasing herbicide resistance of plants and identifying herbicide resistant variants of acetyl-CoA carboxylase are also provided.
Owner:ARCH DEVMENT
High-yield fumaric acid Rhizopus delemar engineering bacterium and application thereof
InactiveCN103013843AExcess accumulation promotesOveraccumulation RealizedFungiMicroorganism based processesPyruvate synthesisBacterial strain
Owner:JIANGNAN UNIV
Methods for improving malic acid production in filamentous fungi
InactiveUS20110053233A1Reduce mitochondrial importImprove the level ofFungiPeptidesHeterologousNucleotide
The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants.
Owner:NOVOZYMES INC
Method of producing biologically active vitamin K dependent proteins by recombinant methods
InactiveUS20080045453A1Easy to producePeptide/protein ingredientsMammal material medical ingredientsGlutamyl carboxylaseEpoxide
The invention relates to commercially viable methods for producing biologically active vitamin K dependent proteins, particularly Factor IX. Factor IX is produced at a level of at least about 15 mg / L and is at least 25% biologically active. The method relies upon co-expression of one or more of paired basic amino acid converting enzyme (PACE), vitamin K dependent epoxide reductase (VKOR) and vitamin K dependent γ-glutamyl carboxylase (VKGC) at a preferred ratio so that the vitamin K dependent protein is efficiently produced and processed by a recombinant cell.
Owner:THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
Microorganism producing o-acetyl-homoserine and the method of producing o-acetyl-homoserine using the microorganism
Disclosed is a strain of Escherichia sp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing O-acetyl homoserine using the strain is provided.
Owner:CJ CHEILJEDANG CORP
Acc inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same. Specifically, bicyclic heteroaryl derivatives containing a imidazole, thiazole or oxazole fused to a pyridinone, pyrimidinone or pyrimidindione are provided. These compounds have therapeutic utility toward treating an ACC enzyme mediated disorder such as obesity in a subject, upon administration in an effective amount to said subject.
Owner:NIMBUS DISCOVERY INC
Acc inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:GILEAD APOLLO LLC
ACCase mutant protein enabling plant to have herbicide resistance, and application thereof
PendingCN108359646AHerbicide resistantMicrobiological testing/measurementLigasesAcetyl-coenzyme A carboxylaseQuizalofop-ethyl
The invention discloses a rice ACCase mutant protein. The amino acid sequence of the ACCase mutant protein has any one or more of mutations in the 1792th position, the 2015th position, the 2038th position, the 2052th position and the 2089th position of the amino acid sequence of the rice ACCase. The invention also discloses a nucleic acid or a gene for encoding the protein. A plant expressing themutant protein has resistance (tolerance) to an acetyl-CoA carboxylase herbicide. After 3 mL quizalofop-ethyl / L water (2 times recommended concentration) is applied to a rice three-leaf seedling of the rice ACCase protein, the plant can still normally grow and seed.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Foliar fertilizer used for enhancing photosynthesis of plants, and its preparation method
ActiveCN103819270AAvoid accumulationSolve the problem of poor color and low qualityFertilizer mixturesPhosphateSodium bisulfate
The invention relates to a foliar fertilizer used for enhancing the photosynthesis of plants, and its preparation method. The foliar fertilizer which is a composition comprises a part A and a part B, the part A comprises 1-3% of chitosan, 1-3% of ribulose-1,5-bisphosphate carboxylase, 5% of a surfactant, 1-5% of an antifreeze agent, 5-10% of acetic acid, 10% of ethanol, 0.1-0.2% of a stabilizer, and the balance water, and the pH value of the part A is 4-6; the part B comprises 5-5% of sodium bisulfate, 5-10% of biochemical fulvic acid, 1-5% of the antifreeze agent, 5% of the surfactant, 5-10% of potassium dihydrogen phosphate, 5-10% of urea, 1-3% of magnesium sulfate, 0.1-0.2% of a stabilizer, and the balance water, and the pH value of the part B is 7-8; a ratio of the part A to the part B is 1:1; and materials of the part A and materials of the part B are uniformly stirred and mixed at normal temperature to form the composition, and the composition is diluted to 1000-2000 times aqueous solution spray when the composition is used. The foliar fertilizer can effectively solve the problems of bad color and low quality caused by possible-meeting of bad natural environment after too late bag removal of bagged apples.
Owner:SHAANXI PUCHENG MEIERGUO AGROCHEM
Acc inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:NIMBUS DISCOVERY INC
Herbicide-tolerant plants
The present invention provides herbicide-tolerant plants. The present invention also provides methods for controlling the growth of weeds by applying an herbicide to which herbicide-tolerant plants of the invention are tolerant. Plants of the invention may express an acetyl-Coenzyme A carboxylase enzyme that is tolerant to the action of acetyl-Coenzyme A carboxylase enzyme inhibitors.
Owner:BASF AGROCHEMICAL PROD BV
Corynebacterium glutamicum strain for production of 5-aminolevulinic acid and construction and application of corynebacterium glutamicum strain
InactiveCN106047916AIncrease productionHigh yieldBacteriaMicroorganism based processesPhosphoenolpyruvate carboxylasePhosphoric acid
The invention discloses a corynebacterium glutamicum strain for production of 5-aminolevulinic acid and construction and application of corynebacterium glutamicum strain. A construction method includes: (1) deleting a lactic dehydrogenase coding gene 1dhA and acetic acid generation genes pta-ackA, pqo and cat in corynebacterium glutamicum to obtain a strain named CB4; inserting a strong sod promoter in front of a phosphoenolpyruvate carboxylase coding gene ppc in the strain CB4 to obtain a strain CB5; deleting a gene pck in the strain CB5 to obtain a strain CB6; (2) transferring plasmid pXA and plasmid pEP2<tuf>-rhtA into the strain CB6. The strain constructed according to the method is capable of generating 2.78g / L 5-aminolevulinic acid in a culture medium with 10g / L glucose serving as a carbon source, which lays a foundation for subsequent continuous feeding of a fermentation tank to increase yield of the 5-aminolevulinic acid.
Owner:TIANJIN UNIV
Rice ACCase mutant gene and application thereof in herbicide resistance of plants
The invention discloses a rice ACCase mutant gene and an application thereof in herbicide resistance of plants. The amino acid sequence of the encoding protein of the ACCase mutant gene has the following mutation: the 1731st siteor / and 2276th site of the amino acid sequence corresponding to the wild type rice ACCase is subjected to mutation. The ACCase mutant gene is introduced into herbicide-sensitive rice genome by a transgenic method and is expressed; and receiver plants can have resistance to acetyl-CoA carboxylase inhibitor herbicide. The ACCase mutant gene can be widely applied to the breeding of plants with the herbicide resistance.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Coryneform bacterium transformant and process for producing dicarboxylic acids using the same
ActiveUS7368268B2Improve productivityHigh expressionBacteriaSugar derivativesPyruvate synthesisGenetic engineering
Owner:RES INST OF INNOVATIVE TECH FOR THE EARTH
Genetic engineering bacterium for producing succinic acid and method for producing succinic acid by fermentation of genetic engineering bacteria
InactiveCN102399738AImprove biosynthetic abilityIncrease productionBacteriaMicroorganism based processesPhosphoenolpyruvate carboxylaseEscherichia coli
The invention belongs to the technical field of bioengineering, and relates to a genetic engineering bacterium for producing succinic acid and a method for producing the succinic acid by fermentation, in particular to a recombinant strain which is grown by utilizing xylose efficiently and is used for producing the succinic acid and a method for producing the succinic acid by utilizing the fermentation of the strain. The genetic engineering strain for producing the succinic acid belongs to the class of Escherichia coli BA204, and the conservation register number is CCTCC No:M2011207. A construction process comprises the steps of: inactivating or removing phosphoenolpyruvate carboxylase, and over-expressing phosphoenolpyruvate carboxylation kinase, so that the recombinant Escherichia coli can be grown by utilizing xylose metabolism to improve the synthetic efficiency of the succinic acid is improved substantially. In the fermentation method, a two-stage fermentation mode is adopted, wherein in an aerobic stage, biomass is improved; and in an anaerobic stage, acid is produced by the fermentation.
Owner:NANJING UNIV OF TECH
Rice Rubisco large-subunit antigen epitope, large-subunit antibody and applications of antibody
InactiveCN103952389AHigh potencyHigh affinitySerum immunoglobulinsBiological material analysisEpitopeOxygenase
The invention rice photosynthesis key enzyme-ribulose-1,5-bisphosphate carboxylase / oxygenase (Rubisco) large-subunit antigen epitope, a polyclonal antibody resisting rice Rubisco large-subunit, and a preparation method and applications of the antibody. The amino acid sequence of the rice Rubisco large-subunit specific antigen epitope is as shown in SEQ ID NO:1. The preparation method comprises the following steps: synthesizing a polypeptide; coupling the polypeptide with carrier protein; preparing antiserum from an immune animal; and performing affinity chromatography for purification, thereby obtaining the polyclonal antibody resisting rice Rubisco large-subunit. The polyclonal antibody is high in titer, remarkable in affinity, excellent in specificity, low in preparation cost and high in yield, and can generate specific binding reaction with rice Rubisco large-subunit; an important tool is supplied for the fundamental research on the rice Rubisco large-subunit as well as the research on the relevant physiological functions of the rice Rubisco large-subunit.
Owner:HUAZHONG AGRI UNIV
Methods for producing gamma-carboxylated proteins
InactiveUS7842477B2Increased and decreased coagulationSugar derivativesPeptide/protein ingredientsCarboxysomeBiochemistry
The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and γ-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.
Owner:MEDIMMUNE LTD
Method for knocking out pckA to promote synthesis of acetylglucosamine through bacillus subtilis
ActiveCN105238724AEasy to buildEasy to useBacteriaMicroorganism based processesPhosphoenolpyruvate carboxylaseTricarboxylic acid
The invention discloses a method for knocking out pckA to promote synthesis of acetylglucosamine through bacillus subtilis and belongs to the field of genetic engineering. The method comprises the steps that BSGNK-PxylA-glmS-P43-GNA1 serves as original strains, phosphoenolpyruvate carboxylase (pckA) genes are knocked out through homologous recombination, the reaction that enolphosphopyruvate is converted into oxaloacetic acid in host bacterium cells is blocked, the carbon flux flowing to a tricarboxylic acid cycle is reduced, and accumulation of acetylglucosamine is promoted. In the process that a composite culture medium is used for fermentation, the acetylglucosamine yield of recombination bacillus subtilis with pckA knocked out reaches 29.27 g / L and is increased by 28.1% compared with that of control strains. The method lays a foundation for transforming bacillus subtilis to produce acetylglucosamine in metabolic engineering.
Owner:JIANGSU HEVI BIOTECH CO LTD
Construction and applications of corynebacterium glutamicum mutant strain for producing L-homoserine
The invention discloses construction and applications of a corynebacterium glutamicum mutant strain for producing L-homoserine, and belongs to the technical field of fermentation engineering. Corynebacterium glutamicum ATCC 13032 is taken as a starting strain to knock out regulatory protein McbR, homoserine kinase, transport protein MetD, phosphoenolpyruvate carboxykinase; the expression of isocitrate dehydrogenase is down regulated; transport protein BrnFE, aspartic semialdehyde dehydrogenase and homoserine dehydrogenase are overexpressed; and the expression of aspartate kinase, pyruvate carboxylase and the aspartate kinase I derived from escherichia coli are enhanced. Shake flask culture can be performed on the mutant strain for 48 h, and the yield of L-homoserine can reach 8.8 g / L.
Owner:JIANGNAN UNIV
Fragmentation chytrid mutagenesis method and variant produced by fragmentation chytrid mutagenesis method
The invention relates to a new fragmentation chytrid variant. Especially, the invention relates to a fragmentation chytrid variant with improved DHA (docosahexaenoic acid) content and / or rapid growth speed and a method for producing DHA by utilizing the variant. Besides, the invention also relates to a method for producing the variant, comprising the steps of carrying out mutagenesis on fragmentation chytrid by adopting ultraviolet rays and screening a strain with rapid growth speed and high DHA content under selective pressure of an inhibitor (such as quizalofop) for fat synthesis key enzyme (acetyl coenzyme A carboxylase).
Owner:法国罗凯特兄弟公司
Insecticidal and acaricidal composition containing acetyl coenzyme A inhibitor insecticide
ActiveCN104663668ASynergistic effect is obviousImprove the effect of prevention and controlBiocideAnimal repellantsChemical compositionActive component
The invention belongs to the field of insecticides, and relates to an insecticidal and acaricidal composition containing an acetyl coenzyme A inhibitor insecticide. The composition contains an active component A and an active component B, a weight part ratio of the component A to the component B is 1:99-99:1, the active component A is a compound I represented by a structural formula shown in the invention, and the active component B is selected from acetyl coenzyme A carboxylase inhibitor insecticides / acaricides. The composition has the advantages of obvious synergy and resistance delaying, and can be used for controlling various insects.
Owner:SHENYANG SINOCHEM AGROCHEMICALS R&D CO LTD
Acetyl co-enzyme a carboxylase herbicide resistant plants
ActiveUS20140250543A1Reduce and eliminate activityDecrease in levelBiocideAnimal repellantsAcetyl-coenzyme A carboxylaseWheat plant
The present invention provides for compositions and methods for producing crop plants that are resistant to herbicides. In particular, the present invention provides for wheat plants, plant tissues and plant seeds that contain altered acetyl-CoA carboxylase (ACCase) genes and proteins that are resistant to inhibition by herbicides that normally inhibit the activity of the ACCase protein.
Owner:COLORADO WHEAT RES FOUND
Genetically engineered bacterium for producing L-aspartic acid through fermentation
ActiveCN106434510AGet Rid of Reliance on Petroleum-Based Fumaric AcidCarbon-nitrogen lyasesBacteriaEscherichia coliDry weight
The invention discloses a genetically engineered bacterium for directly producing L-aspartic acid through fermentation. The classification naming of the genetically engineered bacterium is Escherichia coli CM-AS-115, and the preservation number of the genetically engineered bacterium is CCTCC NO: M 2016457. The bacterial strain relates to inactivation of multiple genes, evolution, metabolism and domestication are simultaneously carried out on the bacterial strain which knockouts the multiple genes, and a mutant strain, namely, CM-AS-105, which has a lower respiratory quotient under the aerobic condition and of which the highest dry cell weight is 60-70% of dry weight of an original strain W1485 is obtained; meanwhile, the bacterial strain further relates to over expressions of two genes, wherein the two genes comprise an enol phosphate type pyruvate carboxylase encoding gene (ppc) and an aspartase encoding gene (aspA), and the obtained bacterial strain is CM-AS-115. The genetically engineered bacterium for directly producing L-aspartic acid through fermentation achieves a way of completely adopting renewable biomass resources such as starch and cellulose as raw materials to ferment and prepare the L-aspartic acid, and the way is green and environmentally friendly.
Owner:CHANGMAO BIOCHEMICAL ENG CO LTD
Plant expression vector of arabidopsis thaliana cytosolic malate dehydrogenase gene and application thereof
InactiveCN101586116ADetoxifyImprove the ability to resist aluminum poisoningFermentationVector-based foreign material introductionNicotiana tabacumWild type
The invention in particular relates to a plant expression vector pH2-35S-PrbcS-AMDH for improving the aluminum toxicity resistance of plants, a construction method and application thereof, which belong to the field of plant gene engineering. The special vector pH2-35S-PrbcS-AMDH for improving the aluminum toxicity resistance of the plants is the plant expression vector containing a photoinducible promoter (PrbcS) of a rubulose-1, 5-bisphosphate carboxylase (RubIsco) small subunit gene and an arabidopsis thaliana cytosolic malate dehydrogenase gene (AMDH). The AMDH gene is cloned from arabidopsis thaliana, the photoinducible promoter is used to control the overexpression of the AMDH gene in tobacco, malic acid is synthesized, and the malic acid is secreted out of cells so as to strengthen the resistance of the plants on aluminum toxicity in acid soil. Experimental results show that the activity of malate dehydrogenase of trans-AMDH genic tobacco leaves is 1.4 times of that of wild tobacco. Under the stress of 30 mu M of aluminum toxicity, trans-AMDH genic tobacco can secrete more organic acid, and has better root system growth; and the growth condition under the stress of the aluminum toxicity shows that the plant height and the green leaf number of the trans-AMDH genic tobacco are higher than those of the wild tobacco.
Owner:KUNMING UNIV OF SCI & TECH
Herbicide-tolerant plants
Owner:BASF SE
Crynebacterium glutamicum engineering strain for producing 5-aminolevulinic acid and construction method thereof+
The invention discloses a crynebacterium glutamicum engineering strain for producing 5-aminolevulinic acid and a construction method thereof. The construction method comprises the steps of 1, knocking out lactic dehydrogenase encoding gene idhA, and acetic acid generation genes pta-ackA, pqo and cat in the corynebacterium glutamicum, inserting a strong sod promoter in front of a phosphoenolpyruvate carboxylase encoding gene ppc, knocking out a phosphoenolpyruvate carboxykinase pck, thus acquiring the strain CB6; 2, knocking out a penicillin-binding protein encoding gene pbpla in the strain CB6, thus acquiring the strain CB7; transferring the plasmid pXA of a built over-expressed 5-aminolevulinic acid synthase gene into the strain CB7, thus acquiring the engineering strain L2. According to the engineering strain provided by the invention, the 5-aminolevulinic acid is produced in a medium in which 10g / L glucose is added as a carbon source; compared with reference strains, the engineering strain is respectively improved by 13.53% and above.
Owner:TIANJIN UNIV
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