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79 results about "Avermectines" patented technology

Dermatological compositions comprising avermectin nanocapsules

Compositions and nanoemulsions containing lipid nanocapsules dispersed in a hydrophilic phase, such nanocapsules including at least one avermectin compound, are useful for the treatment of dermatological pathologies, e.g., rosacea.
Owner:GALDERMA HLDG SA

Avermectin nanometer microemulsion and preparation method thereof

The invention discloses an avermectin nanometer microemulsion and a preparation method and application thereof. The avermectin nanometer microemulsion comprises following constitutes according to percent by weight: 0.5 percent of avermectin, 1 percent of medicine carrier, 0.95 percent of cosolvent, 15 percent of solvent, 6 percent of surfactant A, 0.1 percent of surfactant B, 0.2 percent of stabilizer and 76.25 percent of water. The prepared avermectin nanometer microemulsion is basically of a spherical shape, is uniform in particle size, is singly dispersed, cannot be adhered, and has high dispersion performance and biological availability, and the technological blank of the avermectin nanometer microemulsion is filled.
Owner:SOUTH CHINA AGRI UNIV

Preparation of avermectin medicament sustained-release nano microsphere preparations and uses thereof

The invention relates to a process for preparing avermectin and derivant dimethylamino avermectin, ivermectin, and doramectin slow release nanometer micro-balloon preparation. The technical procedures comprise suspending the suspending solution of 1%-40% unequal avermectin-type medicine, 0%-4% divinylbenzene (cross linking agent), (metyl group) methyl acrylate of 1% BPO (initiating agent) or solvent of methacrylic acid glycidyl ester in an aqueous phase of 40 DEG C with 1% sodium dodecyl benzene sulfonate and 0.5% gelatine or 0.5% PVA (the size ratio of an oil phase and the aqueous phase is 1:3) in a three-mouth bottle with an agitator, a reflux condensing tube and a thermometer, adding numerous ml of 0.5% methylene blue, regulating ultrasonic homogenization power, heating-up to 61 DEG C at 5 DEG C/10mins after the grain size is even, aggregating for two hours, heating-up to 85 DEG C with the same speed, aggregating for 8 hours and preparing 50nm-100nm avermectin-type medicinal nanometer micro-balloon preparation with different medicine-loading amount, and the packaging and loading rate reaches more than 91%. The invention solves the problem of long-acting controlled release of biological medicament, reduces the toxic and side effect simultaneously, improves the biological availability, reduces the cost and is friendly to the environment.
Owner:INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI

Methylamino avermectin benzoate soluble granule and preparation method thereof

The invention discloses a methylamino avermectin benzoate soluble particle agent and preparing method in the pesticide product domain, which comprises the following parts: methylamino avermectin benzoate original-drug, beta-cyclodextrin, nonyl phenol polyoxyethylene ether NP40 surface activator, sodium dodecylbenzene sulfonate ABS-Na surface activator, sodium bicarbonate and anhydrous citrate according to certain weight percentage. The manufacturing method comprises the following steps: blending methylamino avermectin benzoate original-drug, beta-cyclodextrin and ABS-Na surface activator in the water, homogenizing under high-pressure, spraying, drying, preparing composite mother drug, dissolving NP40 surface activator to blend with sodium bicarbonate and anhydrous citrate, obtaining plastic agent, squeezing into column shaped particle, drying in the vacuum to produce the drug.
Owner:佳木斯兴宇生物技术开发有限公司

Broad-spectrum pesticide emulsion-in-water formula

The invention discloses a broad-spectrum pesticide emulsion-in-water formula. The broad-spectrum pesticide emulsion-in-water formula includes, by weight, 1-3% of avermectins, 20-35% of PHMG (polyhexamethylene guanidine), 0.5-1.5% of high-solubility polyvinyl alcohol, 20-40% of organic silicon, and 32-52% of seaweed extract. The problems of decreased pesticide quality, environmental pollution and the like due to excessive use of pesticides can be solved effectively, the broad-spectrum pesticide emulsion-in-water formula is stable in performance, simple, feasible, low-cost and convenient for large-area popularization and application, and agricultural substantial development can be promoted effectively.
Owner:青岛农特生物科技有限责任公司

Compositions comprising at least one aqueous phase and at least one fatty phase which comprises avermectin compounds

Pharmaceutical / dermatological emulsions containing at least one avermectin compound, notably ivermectin, include at least one fatty phase and at least one aqueous phase, the at least one avermectin compound being solubilized in the fatty phase, which emulsions are useful for the treatment of a variety of dermatological conditions / afflictions, in particular rosacea.
Owner:GALDERMA HLDG SA

Method for increasing yield of avermectin by using regulatory protein gene

The invention discloses use of a regulatory protein gene in streptomyces avermitilis. The inactivation of the gene can obviously change the ability of the streptomyces avermitilis to generate an avermectin. The regulatory protein gene comprises an avaL2 gene, an avaR1 gene or an avaR2 gene, wherein the gene replaced mutation strains of the avaL2 gene and the avaR1 gene can obviously improve avermectin generating ability and the gene replaced mutation strain of the avaR2 gene can obviously reduce the avermectin generating ability. The invention also discloses a method for generating the streptomyces avermitilis mutation strain by using the genes, and the application of the streptomyces avermitilis mutation strain, wherein the streptomyces avermitilis mutation strain is increased in the yield. Compared with the yield of the avermectin obtained from an unmodified strain, the yield of the avermectin obtained by fermenting the corresponding mutation strain is greatly increased.
Owner:SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI

Water emulsion containing avermectin and carbosulfan and its preparation method

The invention discloses a water emulsion containing avermectin and carbosulfan and its preparation method. The water emulsion uses avermectin and carbosulfan as basic components and water as dispersion medium, to be formed into uniform and flowable water emulsion through adding adjuvants and high shear dispersion of a homogenizer. In the invention, the effective components and auxiliary carriers comprises (by wt%) avermectin and carbosulfan composite 5-30, emulsifying agent 1-15, cosolvent 1-15, stabilizer 1-5, dispersant 1-15, antifreezing agent 2-10, antifoaming agent 0.1-1, and water as balance.
Owner:JIXI NONGHUA BIOTECH +2

Novel reaction kettle for producing methylamino avermectin benzoate

The invention discloses a reaction kettle which comprises a vertical cylindrical kettle body, wherein the kettle body is provided with a kettle cover, a viewing mirror, a liquid longitudinal circulation system, a material port, a temperature probe and the like; a cooling jacket is arranged on the outer wall of the kettle body; a stirring device is arranged in the kettle body and penetrates through the kettle top to be connected with a power device; an air-pressure sealing device is arranged outside the rotatable connection part between the stirring device and the kettle top; the stirring is divided into three layers, wherein the three-vane propulsive stirring is performed at the bottom layer, and two-vane inclined-paddle type stirrers are arranged on the two layers above; annular pipes are arranged in the kettle body and connected by fin pipes; the kettle body, the kettle cover, the annular pipes and the fins are all made from 304 steel; and the outer layer is provided with the cooling jacket made from carbon steel. Compared with the existing reaction kettle, the reaction kettle disclosed by the invention has novel design, can mix the materials more sufficiently, improves the heat exchange efficiency, reduces the manufacturing cost, and particularly obviously improves the product conversion efficiency and reaction effect in the production of emamectin benzoate and improves the product quality.
Owner:DAQING JEFENE BIO CHEM

Coated coccid killing medicinal liquid used for plant shooting and leaf surface and mixing preparation method thereof

The invention relates to a dressing coccidology killing solution used in steam, wherein the invention is characterized in that: it is formed by avermectin, imidacloprid, shelf element and nitrogen ketone, while their ratio is 0.3-0.5:1.4-1.8:8-12:0.4-0.6. The invention can absorb and kill, to form at the surface of plant, to kill the pest in two hours. And it can kill the pest inside the tree in 4-7 days more than 95%. The dressing agent and drug form micro capsules covering the plant while its effective period is more than one month.
Owner:周弘

Method for prevention and control of vegetable root-knot nematodiasis with mixed Sr18 biological nematocide

The invention discloses a method for prevention and control of vegetable root-knot nematodiasis with mixed Sr18 biological nematocide. The method includes: preparing the mixed Sr18 biological nematocide from 8-time concentrated aqueous solution of Sr18 and avermectin emulsion according to a weight part ratio of 7.5:2; subjecting soil to rotary tillage before use of the mixed Sr18 biological nematocide, dividing plots according to areas of test plots, ridging, taking corresponding Sr18 agent and avermectin emulsion according to the preparation ratio at the step (1), uniformly mixing, adding clean water for diluting by 10-20 times, adopting spraying equipment for soil spraying, transplanting in 3-5 days after application of the mixed Sr18 biological nematocide, and additionally applying the nematocide for 1-2 times to long-season vegetables in the middle period of planting by irrigating the nematocide along with water and keeping the dosage and proportion unchanged; detecting conditions of vegetable root-knot nematodiasis. Experiment results show that root-knot nematodiasis can be effectively controlled by the method, consumption and utilization frequency of avermectins are greatly reduced, the picking period of cucumbers is greatly prolonged by about 3 months, and fruit setting rate of tomatoes is increased by 30%.
Owner:TIANJIN NORMAL UNIVERSITY

Method used for increasing industrial avermectin B<1a> yield via optimization of fermentation medium

The invention relates to a method used for increasing industrial avermectin B<1a> yield via optimization of fermentation medium. It is found via large scale of screening that adding of an appropriate concentration of calcium chloride into streptomyces avermitilis fermentation medium is capable of increasing B<1a> yield obviously. The invention also provides a medium used for the method.
Owner:上海国佳生化工程技术研究中心有限公司 +1

CAPS marking method for detecting avermectin resistance related gene mutation of spider mites

The invention discloses a CAPS marking method for detecting avermectin resistance related gene mutation of spider mites. Spider mite population GluCl3 gene to be detected which contains a gene fragment with G326E mutation is amplified, and enzyme sites are analyzed, wherein a Hinf I enzyme site exists in the amplified fragments of the sensitive population, and the site does not exist in the resistance homozygosis population, amplified fragments containing the Hinf I enzyme site exist in the resistance heterozygosis population, and amplified fragments without the site exist in the resistance heterozygosis population. The method can be used for replacing traditional biological assay methods, and has the advantages of little manpower and few sample amounts, large detection quantity, high sensitivity, good specificity, rapid and simplicity, and accuracy and reliability; the method is suitable for rapid diagnosis of avermectin resistance of Tetranychus urticae field population, and is usedfor carrying out real time monitoring and early warning forecast of avermectin resistance of field spider mites at the same time; the method has important meaning for avermectin resistance monitoringof field spider mites, and application prospect is wide.
Owner:INST OF VEGETABLE & FLOWERS CHINESE ACAD OF AGRI SCI

Quick analysis method for reaction process of emamectin benzoate

The invention discloses a quick analysis method for a reaction process of emamectin benzoate and relates to an analysis method for a chemical reaction intermediate process. By utilizing the method, the problems that the time for high performance liquid chromatograph is long, the operation steps are minute and complicated, the detection is time-consuming, a large number of samples need to be measured, the provided experimental data often lags behind the production process, the monitoring of the production process is incomplete and problems can not be found in time are solved. The method comprises the following steps: 1) establishing a sample library; 2) establishing a sample spectral pattern library; 3) selecting a sample; 4) carrying out pretreatment on the sample; 5) establishing a standard sample model; 6) establishing a quantitative analysis model, and getting an optimal quantitative analysis model; and 7) collecting spectral information of the sample to be tested, and predicting the contents of residual avermectin B1a and double-protection matter in the sample to be tested through the optimal quantitative analysis model. The analysis of the sample can be completed within 1 minute by the method, thus the method is time-saving, labor-saving and cost-saving and is easy for operation.
Owner:HARBIN INST OF TECH
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