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Parasiticidal composition

一种组合物、抗寄生物的技术，应用在杀灭寄生物的组合物领域

Inactive Publication Date: 2006-08-23
NORBROOK LABORATORIES LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time the publication also provides test results for agents which, as described in the comparative examples below, have shown limited success in delivering the active ingredient to the blood system of the treated animal.

Method used

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  • Parasiticidal composition

Examples

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preparation example

[0044] In order to prepare a dual combination product for suspension delivery, the total amount of the active ingredients provided is cyliosamide and ivermectin, which is 10% (w / v) cyliosamide in the delivery solution And 0.5% (w / v) ivermectin. The drug delivery system used includes solvents PEG 200, ethanol and isopropanol, together with a permeability enhancer, the solvent is to facilitate the supply of effective active solution. Examples of formulations of several compositions are as follows:

[0045] Formulation 1

[0046] Ivermectin 0.25%w / v

[0047] Cyliosamide 5.0%w / v

[0048] Ethanol 30%v / v

[0049] Isopropanol is supplemented to 100% v / v

[0050] Formulation 2

[0051] Ivermectin 0.5%w / v

[0052] Clorisamide (in the form of sodium salt) 10.0%w / v

[0053] PVP 15.0%w / v

[0054] Ethanol 20%v / v

[0055] PEG200 20%v / v

[0056] Isopropanol is supplemented to 100% v / v

[0057] Formulation 3

[0058] Ivermectin 0.5%w / v

[0059] Cyhalosalamide 10.0%w / v

[0060] PVP 6.0%w / v

[0061...

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Abstract

An anti-parasitic pour-on composition for treating animals comprises a salicylanilide, especially closantel, alone or together with at least one other anti-parasitic compound of the avermectin or milbemycin type and offers enhanced bioavailability of the salicylanilide by provision of a delivery system comprising at least 20%(v / v) of one or more alcohols. The composition optionally includes a polymeric moiety selected from polyvinylpyrrolidone (PVP), polyoxypropylene / polyoxyethylene block copolymers (poloxamer), and polyethylene glycols (PEG), thereby improving the bioavailability of e.g. closantel (as assessed with respect to blood plasma levels of closantel).

Description

Technical field [0001] The present invention relates to a composition for killing parasites, especially a veterinary compound product based on the combination of salicylanilide and another agent for killing parasites, such as avermectin or double maixin (Milbemycin), this compound product is more effective against a broad spectrum of parasites than using a single parasite-killing agent alone. Background technique [0002] Warm-blooded animals are easily bitten by parasites. People have long sought to fight against these parasites that afflict domestic pets, farm animals and wild animals in order to alleviate the suffering caused by parasites and obtain commercial benefits. The way the parasite bites and the identification of the sensitive stage in its life cycle have a great influence on the choice of parasite killer. Therefore, the typical extradermal treatment of ectoparasites is usually to use lotions, poultices, creams, colloids, release agents, suspensions (pour-ons) or disi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P33/14A61K31/609A61K31/365A01N37/40A61K31/045A61K45/06A61P33/00
CPCA61K45/06A01N37/40A61K31/045A61K31/609A61P33/00A61P33/10A61P33/14A01N43/90A01N31/02A01N25/10A01N2300/00A61K2300/00
Inventor 威廉·布莱克利莉莲·克罗米
Owner NORBROOK LABORATORIES LIMITED
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