The invention provides a low-toxicity and high-efficiency insecticide for wheat, and relates to the technical field of pesticides. The low-toxicity and high-efficiency insecticide for wheat is prepared from the following raw materials in parts by weight: 80-90 parts of herba artemisiae scoparzae, 10-20 parts of achnatherum inebrians endophytes, 3-5 parts of sodium alkyl benzene sulfonate, 5-10 parts of fenpropathrin, 1-3 parts of cypermethrin, 18-45 parts of pyroligneous, 2-5 parts of captan, 8-10 parts of thiram, 3-5 parts of mancozeb, 20-30 parts of plant extract, 0.5-1 part of manganese sulfate, 15-20 parts of fructus gleditsiae powder, 10-20 parts of herba houttuyniae, 10-12 parts of matrine, 10-15 parts of oxymatrine, 8-10 parts of fructus cnidii extract and 2000-3000 parts of water.The low-toxicity and high-efficiency insecticide for wheat, provided by the invention, has better insecticidal, bactericidal and antibacterial functions, can inhibit reproduction of infectious microbes under low concentration, has anti-bacterial and anti-insect effects, has obvious effects on prevention and treatment of diseases and insect pests of wheat, and has low toxicity and high insecticidalefficiency.