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47results about How to "Slow proliferation" patented technology

Aptamer-mediated regulation of gene expression

This invention provides methods of regulating gene expression. An aptamer is positioned in a nucleic acid molecule along with a sequence encoding a transcriptional regulatory polypeptide. The aptamer disrupts translation of the transcriptional regulatory polypeptide when contacted with an aptamer-binding ligand. Gene expression levels can be either increased or decreased by the disclosed methods, depending on whether the transcriptional regulatory polypeptide is a repressor or activator, and the degree of the effect is dependent upon the dose of the ligand. Nucleic acid molecules, expression cassettes, expression vectors and cells useful in the gene regulation methods are also provided.
Owner:CANJI

Cancer stem cell-targeted cancer therapy

InactiveUS20080118518A1Stabilizing and reducing and cell populationPromote growthBiocideAntibody ingredientsRegimenCancer cell
The present invention provides methods for stabilizing, reducing or eliminating cancer cells. In particular, the present invention provides prophylactically and / or therapeutically effective regimens for the prevention, treatment and / or management of cancer, the regimens comprising administering one or more cancer therapies to a subject to reduce a cancer cell population. The therapy(ies) in the prophylactically and / or therapeutically effective regimen can be administered at a lower dose than currently used or known to one of skill in the art and / or for a longer period of time and / or more frequently than currently administered or known to one of skill in the art.
Owner:STEMLINE THERAPEUTICS

Starting method for rapid and efficient short-cut nitrification

The invention discloses a starting method for rapid and efficient short-cut nitrification. The method comprises the following steps: guiding inoculated sludge which is rich in nitrobacteria into an SBR (Sequencing Batch Reactor) reactor; guiding sewage into the SBR reactor in order that the concentration of the sludge in the reactor becomes 2,500-3,500mg/L, and controlling the temperature of the sewage at 30+/-1 DEG C and the pH of the sewage at 7.9-8.2; starting an aeration facility in the reactor in order that the concentration of dissolved oxygen becomes 0.8-1.2mg/L; performing aeration for 1.5-2.5 hours; stopping aeration, and starting to stir for 0.5-1.5 hours to uniformly mix the sludge and the sewage; repeatedly aerating and stirring operation for 1-5 times; standing the mixture for separating a solid from a liquid; and draining supernatant. By performing the short-cut nitrification in an intermittent aeration way, the growth of AOB (Ammonia Oxidizing Bacteria) can be better facilitated, a nitrification reaction is restrained, the energy consumption of a reaction device can be lowered effectively, and the starting of the short-cut nitrification of domestic sewage with low ammonia nitrogen content can be realized in comparison to the conventional continuous aeration.
Owner:GUANGZHOU MUNICIPAL ENG DESIGN & RES INST CO LTD

Methods for enhancing survival and/or proliferation of neural stem cells and neurite extension enhancers therefor pharmaceutical compostions containing neural stem cells assay methods and screening methods

Problems to be Solved Methods for enhancing survival and / or proliferation of neural stem cells and pharmaceutical compositions containing neural stem cells prepared by such methods, together with methods for assaying factors enhancing survival and / or proliferation of neural stem cells and methods for screening for such factors. Means for Solving the Problem Either Galectin-1 is overexpressed in neural stem cells or neural stem cells are cultured in a liquid medium containing Galectin-1. Pharmaceutical compositions containing Galectin-1-overexpressing neural stem cells and pharmaceutical composition containing Galectin-1, prepared by the aforementioned methods, improve higher cerebral functions damaged by cerebral ischemia. Further, by seeding neural stem cells at clonal concentrations and determining whether the seeded neural stem cells are capable of proliferating in an assay medium to be assayed, whether the factor enhances survival and / or proliferation of neural stem cells is assayed and a factor enhancing survival and / or proliferation of neural stem cells are identified using this assay method.
Owner:KEIO UNIV
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