The invention discloses a spine-free zanthoxylum bungeanum cultivation method, which comprises land selecting and preparation, seedling raising, ear cutting and grafting, field planting, cultivation management, and seedling raising of spine-free zanthoxylum bungeanum, wherein a seed stirring agent is used during the seedling raising process, and during the ear cutting and grafting, the scion male parent is soaked with an essence liquid so as to improve the healing and scion survival rate of the joint part. According to the present invention, with the grafting of more than three generations, the spine-free or micro-spine characteristic can be stabilized, and the new grafted seedling has characteristics of high survival rate, strong branches, convenient transplanting and good quality.