The invention discloses a novel multi-chamber continuous UHPC box girder bridge superstructure construction method, including UHPC prefabricated longitudinal block beam, UHPC prefabricated longitudinal block side beam, cast-in-place UHPC joint, prefabricated steel connector, shear force Nails, pre-embedded steel backing plates, pre-embedded bolts, temporary supports, permanent supports, stiffened beams, cast-in-place UHPC bottom plates, cast-in-place UHPC webs, cast-in-place UHPC roofs and thickened areas, simply supported system girders, stiffeners Beam floor, main beam web. The beneficial effect of the present invention is: the multi-chamber UHPC box girder is prefabricated in longitudinal blocks, assembled and connected on site through special connectors, and several multi-chamber simply supported box girders are first formed, and then passed on the pier by special The pouring method makes the box girder structure change from simply supported to continuous. The structural quality is excellent, the splicing is reliable, the mechanical performance and durability are good, the construction is convenient, the construction period can be greatly shortened, and the space under the bridge can be saved, which is very suitable for the needs of construction and development.