96results about How to "Reduce the risk of drug resistance" patented technology

The invention discloses an application of a compound pulchinenoside B4 shown as a formula I or pharmaceutically acceptable salt thereof in the preparation of drugs for treating viral and / or bacterialdiseases. The pulchinenoside B4 is a natural effective component extracted and separated from a traditional Chinese medicinal material Chinese pulsatilla root, and is non-toxic and non-drug resistant.The compound pulchinenoside B4 has strong biological activity and excellent treating effects on cow mastitis, and the abandonment of milk is not needed during treatment and at the end of treatment, so that the economic loss of farmers can be reduced, and risks of drug resistance generation can be reduced as well. In addition, the pulchinenoside B4 has excellent treating effects on clinic mastitisand also on long-term cure and recessive mastitis. A pulchinenoside injection has the characteristics of being safe and efficient and has no residues, no drug resistance and no toxic side effects when being applied to the treatment of cow mastitis.

The invention relates to hygienic insecticidal granules and a preparation method thereof. The hygienic insecticidal granules are prepared from the following components in parts by weight: 0.1 to 10% of an active component A, 0.1 to 40% of an active component B, 0.2 to 20% of a solvent, 0.1 to 5.0% of an emulsifier, 0.1 to 5.0% of a dispersant, 0.1 to 5.0% of a slow-release film forming agent, 0.1 to 5.0% of a fast-release film forming agent, 0.1 to 10% of an adsorbent, and the balance of a porous carrier. The active component A is a slow-acting reagent, namely Bacillus thuringrensis israelesis Bti or pyriproxyfen; the active component B is selected from the group of fast-acting type neurotoxic reagents, namely fenthion, temephos, chlorpyrifos, pirimiphos-methyl, abamectin, ivermectin, and emamectin benzoate; the active component A is used for being adsorbed into the porous carrier which is wrapped with the active component B; the slow-release film forming agent is a hydrophobic high molecular polymer; the fast-release film forming agent is a water-soluble high-molecular polymer. The specific slow-release film forming agent and the fast-release film forming agent are selected, especially, the composite slow-release film forming agent, the composite fast-release film forming agent and corresponding insecticidal active components which are further compounded in a specific ratio are good in compatibility and have better fast-release and slow-release effects.