105results about How to "Potent inhibition" patented technology

The present invention provides a system and apparatus for efficient and reliable, control and distribution of data files in large-scale distributed networks. The members of a group of servers in a multicast network elect a group leader whenever a new group leader is required, as when the prior group leader become unavailable, as detected by absence of a periodic heartbeat message published by the leader. The election is carried out by a system of voting by each candidate whereby each candidate has a priority calculated from its configuration, and the server with the highest priority is configured to claim the leadership faster than the other candidates. As part of the claim, each candidate multicasts its priority. Each candidate that receives a multicast claim for leadership from another candidate compares its own priority against the claimant and only votes for itself if its own priority is higher. After a preconfigured period of hearing no other claimants with higher priority, the candidate with the highest priority becomes the new leader.

A non-volatile semiconductor device has a memory cell array having electrically erasable programmable non-volatile memory cells, reprogramming and retrieval circuits that temporarily store data to be programmed in the memory cell array and sense data retrieved from the memory cell array. Each reprogramming and retrieval circuit has a first latch and a second latch that are selectively connected to the memory cell array and transfer data each other. A controller controls the reprogramming and retrieval circuits on data-reprogramming operation to and data-retrieval operation from the memory cell array. Each reprogramming and retrieval circuit has a multilevel logical operation mode and a caching operation mode. In the multilevel logical operation mode, re-programming and retrieval of upper and lower bits of two-bit four-level data is performed using the first and the second latches in storing the two-bit four-level data in one of the memory cells in a predetermined threshold level range. In the caching operation mode, data transfer between one of the memory cells selected in accordance with a first address and the first latch is performed while data transfer is performed between the second latch and input / output terminals in accordance with a second address with respect to one-bit two-level data to be stored in one of the memory cells.

A crosslink or connecting assembly is provided to secure multiple spinal rods in relation to each other. The connecting assembly is disposed transversely between two spinal rods and has moveable components for rotating, pivoting, and extending portions of the connecting device in order to accommodate the positioning of the spinal rods.

A flow management system comprising a first panel having a fluid pathway and a second panel having a fluid pathway for passing a second fluid. The fluid pathway of the first panel passes a first fluid. The first panel includes a first compartment to receive a volume of the first fluid. The second panel includes a second compartment to receive a volume of the second fluid. The first and second panels are aligned so that the first compartment overlays the second compartment. The flow management system may be placed within a gap defined by a first surface and a second surface. The first and second compartments are disposed within the gap so that the second compartment bears against the second surface as the second fluid fills the second compartment and forces the first fluid out from the first compartment as the first compartment bears against the first surface.

A method for distributing information to a plurality of servers is described. The information is transmitted from a control manager server to a first group leader server. The first group leader server transmits the information to a second group leader server. The second group leader server requests instructions from the control manager server. The second group leader server then transmits, in response to the instructions, the information to a further group leader server. The first group leader server transmits the information to back end servers belonging to a group of the first group leader server. The second group leader server transmits the information to back end servers belonging to a group of the second group leader server. The further group leader server transmits the information to back end servers belonging to a group of the further group leader server.

A semiconductor device having a normal function means is provided, in which the amplitude of an output signal is prevented from being decreased even when a digital circuit using transistors having one conductivity is employed. By turning OFF a diode-connected transistor 101, the gate terminal of a first transistor 102 is brought into a floating state. At this time, the first transistor 102 is ON and its gate-source voltage is stored in a capacitor. Then, when a potential at the source terminal of the first transistor 102 is increased, a potential at the gate terminal of the first transistor 102 is increased as well by bootstrap effect. As a result, the amplitude of an output signal is prevented from being decreased.

Vascular prostheses and methods of use are provided, wherein the vascular prosthesis includes a plurality of bistable unit cells configured to form a helical structure. A visualization catheter also is provided for use ensuring accurate measurement of a lesion and ensuring delivery and placement of the vascular prosthesis.

A hose-end sprayer has a selectively rotatable rotary valve received within the transverse bore of a housing which includes a carrier liquid inlet passage, a chemical liquid inlet passage and a discharge passage. The valve has a carrier liquid duct and a chemical liquid duct opening into the carrier duct for interconnecting the inlet passage in a first rotative position of the valve, and the valve is capable of closing the inlet passages in a second rotative position of the valve. The rotary valve is selectively rotatable in a third position for interconnecting the liquid passage only with the discharge passage in a rinse position of the valve. Container venting is isolated from a valve chamber in which the rotary valve operates to avoid entry of carrier liquid into the container through the open vent in the ON position of the valve upon its selective rotation.

The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and / or MDM4, or variants thereof, respectively, said compounds having the formula I,whereinR1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and / or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.