40results about How to "Less prone to tolerance" patented technology

The invention synthesizes four novel endomorphin-1 analogs, and belongs to the technical field of biochemistry. The endomorphin-1 analogs are prepared by performing N-end guanidyl formation at the first-position Tyr of endomorphin-1, replacing the second-position Pro by D-Ala, replacing the third-position Trp by Gly, and replacing the fourth-position Phe by Trp or performing para-position chlorination and fluorination modification or no modification on a benzene ring of Phe. The synthesized endomorphin-1 analogs are subjected to a series of physiological and pharmacological activity identification such as radio-ligand receptor binding assays, isolated organ bioactivity identification experiments, isolated enzymolysis stability experiments, analgesic tests with water bath and medicine tolerance experiments, show high affinity activity, high enzymolysis stability and high analgesic activity, and hardly cause tolerance. Therefore, the four novel endomorphin-1 analogs can be used for preparing clinical analgesic medicines.

The present invention relates to a cervical and lumbar treatment instrument and a preparation method, including an outer shell which contacts with the human body directly and a heating element which is arranged in the outer shell; the present invention is characterized in that the outer shell is made of bamboo which is scrapped off the outer layer, furthermore, the bamboo experiences the soaking and boiling process with two different traditional Chinese medicine liquid, wherein, a first traditional Chinese medicine liquid is prepared by the raw materials with the following mix ratio by weight: 50 parts of water, 0.8 to 1.2 parts of vitex negundo, 0.7 to 0.95 part of Indian stringbush root and 0.8 to 1.0 part of eucommia ulmoides oliver; a second traditional Chinese medicine liquid is prepared by the raw materials with the following mix ratio by weight: 50 parts of water, 0.8 to 1.2 parts of vitex negundo, 0.7 to 0.95 part of Indian stringbush root and 0.8 to 1.0 part of gardenia jasminoides ellis. The preparation method includes selection of bamboo blocks, soaking and boiling of the bamboo blocks, softening process, drying in the shade, soaking and boiling process of the first traditional Chinese medicine liquid, soaking and boiling process of the second traditional Chinese medicine liquid, assembly and other steps. The treatment instrument has significant alleviating effect of the short-term symptoms of cervical, lumbar and back diseases and pains, furthermore, the present invention can obtain the consolidated and sustained effect after a longer period of the treatment, at the same time, the present invention is also characterized in that the present invention is not easy to generate the tolerance. The preparation method is characterized by simple property, easy obtaining of the materials, low production cost and natural environmental protection.

The invention relates to an anti-aging composition, an anti-aging facial mask and a preparation method thereof. The anti-aging composition comprises hydrolyzed sclerotium gum, glycerol glucoside, alpha-arbutin, oligopeptide-1 and cannabidiol. The anti-aging composition has a relatively strong anti-aging effect and can deeply improve skin and enhance the skin elasticity.

The invention discloses drug composition for treating cancers, a preparation method and applications. The drug composition comprises the components in parts by weight as follows: 1-20 parts of astragaloside and 5-20 parts of pachymaran. The drug composition is formed by combination of effective constituents of natural medicinal materials, can be taken without boiling and has the advantages that the drug composition is good in curative effect, free from toxic and side effects, not prone to tolerance, capable of being prepared into pills, tablets, effervescent tablets, capsules, powder, granules, syrup, oral liquids, freeze-dried injections, injections and the like, convenient to take and carry and the like, each medicinal material is non-toxic and harmless before and after composition extraction, no side effect is found when the normal dose is taken, and the composition is generally applicable to cancer patients.

The invention discloses toothpaste for relieving tooth sensitivity. The toothpaste is prepared from the following raw materials in parts by weight: 70-80 parts of calcium hydrogen phosphate, 30-35 parts of sorbitol, 18-22 parts of glycerol, 2-5 parts of sodium laurylsulfate, 1-2 parts of hydroxypropyl methylcellulose, 3-6 parts of guar gum, 0.5-1.0 part of potassium sorbate, 1.2-1.7 parts of stevioside, 12-16 parts of hawthorn leaf extract, 3-7 parts of edible tulip extract and 6-10 parts of allium macrostemon extract. The invention also discloses a preparation method of the toothpaste for relieving tooth sensitivity. The toothpaste prepared by the preparation method disclosed by the invention can relieve tooth sensitivity, has an obvious effect, adopts Chinese herbal medicinal ingredients, and does not contain fluoride, so that the toothpaste is easier to accept by masses of consumers, and has a broad market prospect.

The invention relates to an efficient compound medicine resisting skin aging and a preparation method thereof. The efficient compound medicine resisting skin aging is prepared from the following various ingredients in proportion by mass: 0.01-0.1% of retinoic acid, 1-5% of glucosamine hydrochloride or N-acetyl glucosamine and the balance of a cream matrix. The preparation method comprises the following steps: adequately dissolving retinoic acid and glucosamine hydrochloride or N-acetyl glucosamine with the proportions in a corresponding amount of polyethylene glycol and mixing by a container; then mixing the mixture with the cream matrix, and stirring for 30 seconds by a superfine homogenizer to obtain the product. According to the preparation method disclosed by the invention, the dosage of retinoic acid is reduced by virtue of the synergistic effect between retinoic acid and glucosamine hydrochloride or N-acetyl glucosamine, and the functions of moisturizing and improving skin elasticity of retinoic acid are improved while skin irritation and adverse reactions are reduced. The efficient compound medicine resisting skin aging disclosed by the invention is simple in formula and convenient to use, and has the good effects of resisting skin aging, resisting wrinkles, resisting inflammation and fading spots.

The invention relates to an apparatus for treating cervical vertebra and lumbar vertebra and a preparation method thereof. The apparatus comprises a housing in direct contact with human body and a heating unit arranged inside the housing, and the apparatus is characterized in that the housing is made of Mao bamboo of which the external green peel is removed and which is subject to digestion treatment of a Chinese traditional medicine liquid made from the following raw materials by weight: 1g of negundo chastetree bud, 0.75kg of Indian stringbush root and 50kg of water. The preparation method comprises steps of selecting bamboo blocks, digestion and softening treatment of the bamboo blocks, drying in the shade, digestion treatment by the Chinese traditional medicine liquid, assembling and the like. The apparatus has significant short-term remission effects on pains of cervical vertebra, lumbar vertebra and back, and solidified and durative treatment effect can be obtained by a longer period of treatment, and at the same time the apparatus is characterized by being not easy to cause tolerance. The preparation method is characterized by simpleness, easy materials, low manufacturing cost, and natural environment protection.

The invention synthesizes four novel endomorphin-1 analogs, and belongs to the technical field of biochemistry. The endomorphin-1 analogs are prepared by performing N-end guanidyl formation at the first-position Tyr of endomorphin-1, replacing the second-position Pro by D-Ala, replacing the third-position Trp by Gly, and replacing the fourth-position Phe by Trp or performing para-position chlorination and fluorination modification or no modification on a benzene ring of Phe. The synthesized endomorphin-1 analogs are subjected to a series of physiological and pharmacological activity identification such as radio-ligand receptor binding assays, isolated organ bioactivity identification experiments, isolated enzymolysis stability experiments, analgesic tests with water bath and medicine tolerance experiments, show high affinity activity, high enzymolysis stability and high analgesic activity, and hardly cause tolerance. Therefore, the four novel endomorphin-1 analogs can be used for preparing clinical analgesic medicines.

The invention discloses a dysmenorrhea patch, belonging to the technical field of traditional Chinese medicine formula. Dysmenorrhea patch of the invention is composed of the following raw material inparts by weight: angelica sinensis 6-10 part, szechwan lovage rhizome of 10-20 parts, rhizoma Cyperi 10-15 parts, rhizoma corydalis 15-30 parts, trogopterus 10-20 parts, folium Artemisiae Argyi 10-15parts, folium Artemisiae Argyi 10-15 part, ramulus Cinnamomi 10-15 part, evodia rutaecarpa 10-15 part, aconite root 10-15 parts, fennel 10-15 part, eucommia ulmoides 10-15 parts,eucommia ulmoides 10-15 part; a Chinese medicinal preparation is prepared by weighing Chinese-medicinal material according to corresponding proportions, pulverize, sieving with 200 mesh sieve, and uniformly mixing; then,the mixture of the mixed Chinese herbal powders was mixed with vaseline and made into 10g pills, which were sealed and stored. The dysmenorrhea patch of the invention has obvious therapeutic effect, small side effect of medicine on human body, is not easy to produce tolerance and has long curative effect.

The present invention discloses a fragrant and crisp Chinese yam slice and a processing method thereof, and relates to the field of food processing. The fragrant and crisp Chinese yam slice comprisesChinese yams, fingerleaf rodgersflower rhizome and citric acid. A layer of fingerleaf rodgersflower rhizome micro-powder is evenly spread on the surfaces of the Chinese yam slice to prevent the browning of the Chinese yam slice. Secondly, the Chinese yams and fingerleaf rodgersflower rhizome are combined; and the fragrant and crisp Chinese yam slice removes greasiness, relieves toxins by frying and roasting, improves digestion, and reduces or even eliminates dyspepsia symptoms possibly happening after eating the oil-fried Chinese yam slice.

The invention discloses a medicine composition for treating a digestive system disease, and a preparation method and use of the medicine composition. The medicine composition is prepared from the following ingredients in parts by weight: 5-20 parts of attractylone, and 5-20 parts of magnolol. The medicine composition disclosed by the invention is prepared from the effective parts of natural medicine raw materials in combination; the medicine composition does not need to be decocted for taking, is good in curative effect, free from toxic and side effects, not easy to produce tolerance, can be prepared into a tablet, a capsule, a pill, a granule, an oral liquid and the like, and has the advantages of portability, easy taking and the like; all the medicines are nontoxic and harmless before and after the extraction; when the medicine composition is taken at normal dosage, no toxic effect and no side effect are found; and the medicine composition is widely applicable to the patients suffering from digestive system diseases.

The invention discloses a jatropha extracting method and antifungal application. The extracting method comprises the following steps: ultrasonically extracting a jatropha medicinal material by taking 10 times volume of methanol as an extracting solvent for three times, wherein each time lasts for 30min, combining extracting liquid, decompressing and concentrating, making a concentrated solution undergo column chromatography on silica gel, eluting in a gradient manner with ethanol differing in concentration, monitoring flavonoid active ingredients by virtue of thin layer chromatography, combining eluent containing the flavonoid active ingredients, decompressing and concentrating, and reserving a concentrated solution for later use. The jatropha extract disclosed by the invention has a significant effect of improving external fungal infection and is applicable to the treatment of skin fungal infection; the extract can be prepared into various dosage forms as required; and used for treating the fungal infection, the jatropha extract has the advantages of being low in side effect, not easy to cause tolerance and the like.

The invention discloses a preparing method of a breathable and cool type non-woven fabric for a vehicle seat cushion, and belongs to the technical field of non-woven fabrics. The problems that an existing non-woven fabric drying device is high in energy consumption and not uniform in heating, so deformation happens to the surface of the non-woven fabric are solved. The method includes the following steps of weighing raw materials required for producing the non-woven fabric, putting the raw materials in a mixer to be stirred and mixed for 3 h, discharging the materials to obtain a first mixture, adding ten folds of water to the first mixture, adding vinyl distearamide to be stirred and mixed to obtain a second mixture, and drying the second mixture at the drying temperature of 120 DEG C. The prepared non-woven fabric is high in breathability, has the advantages of being high in safety, small in toxic and side effect and not prone to tolerance, is more easily accepted by vast consumers and has wide market prospects.

The invention provides a bacteriostatic agent and a preparation method thereof. The bacteriostatic agent is prepared from the following raw materials in parts by weight: 10 to 20 parts of radix ophiopogonis extract, 6 to 10 parts of radix rubiae extract, 4 to 8 parts of radix polygoni multiflori extract, 10 to 20 parts of flos chrysanthemi extract and 5 to 7 parts of rhizoma polygoni cuspidati extract. Compared with the prior art, a composition provided by the invention can be dissolved as required by using water or ethanol to be used in a cleaning product, a bactericidal washing agent and thelike. The bacteriostatic agent has a good sterilization effect, and does not have a side effect; a bacterium and a fungus difficultly generate tolerance. Moreover, the preparation method is simple; ause level is small. A bacteriostatic rate to multiple bacterial virus reaches 99 percent or above, and the bacteriostatic effect is obvious.

The invention discloses a medicine composition for treating acne and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The medicine for treating acne adopts a fermented product which takes traditional Chinese medicine water extract of a traditional Chinese medicine raw material medicine mixture as a culture medium of tremella mother culture, and thetraditional Chinese medicine raw material medicine mixture is prepared from, by weight, 30-50 parts of cocklebur fruit, 10-30 parts of rhizoma imperata, 10-30 parts of radix aconiti, 5-15 parts of cassia, 5-15 parts of tribulus terrestris, 5-15 parts of bile arisaema, 10-30 parts of plantago seeds, 30-50 parts of cicada slough, 10-30 parts of atractylodes, 5-15 parts of rhizoma zingiberis, 5-15 parts of radix sanguisorbae and 10-30 parts of fructus kochiae. The medicine for treating the acne has good curative effect, quick effect and no side effect.

The invention discloses drug composition for treating cancers, a preparation method and applications. The drug composition comprises the components in parts by weight as follows: 1-20 parts of astragaloside and 5-20 parts of pachymaran. The drug composition is formed by combination of effective constituents of natural medicinal materials, can be taken without boiling and has the advantages that the drug composition is good in curative effect, free from toxic and side effects, not prone to tolerance, capable of being prepared into pills, tablets, effervescent tablets, capsules, powder, granules, syrup, oral liquids, freeze-dried injections, injections and the like, convenient to take and carry and the like, each medicinal material is non-toxic and harmless before and after composition extraction, no side effect is found when the normal dose is taken, and the composition is generally applicable to cancer patients.

The invention provides a medicinal composition containing bilobalide B. The medicinal composition contains bilobalide B and a vitamin K antagonist. The invention further provides a preparation method and an application of the medicinal composition. The experiment proves that bilobalide B can obviously promote the anti-platelet aggregation function of warfarin, also can eliminate / reduce the natural drug resistance of a patient generated due to only use of warfarin, and enhance the affinity between the liver receptor of a patient and warfarin, and bilobalide B and warfarin have the synergistic interaction. The medicinal composition is novel in formula, simple in components, definite in action mechanism and obvious in curative effect, tolerance is difficultly generated, and industrial production can be realized.

The invention discloses a medicine composition for treating depression and a preparation method thereof. The medicine composition comprises the following ingredients in parts by weight: 1-2 parts of saikosaponin, 1-2 parts of radix curcumae volatile oil and 1-3 parts of pachymaran. The preparation method of the medicine composition for treating depression comprises four steps of raw material preparation, raw material weighing, raw material inclusion and medicine mixing and forming. The medicine composition is prepared by combining active ingredients of natural medicinal raw materials or extracts of the active ingredients of the medicinal raw materials, and has the advantages that the medicine composition has good curative effects and no toxic or side effects, is not easy to generate tolerance, is universally suitable for depression patients, etc. Being prepared from the extracts of the active ingredients, the medicine composition is taken without decoction, can be applied to the patients by oral administration, suction or parenteral administration, can be prepared into tablets, capsules, powder, granules, syrup or oral liquid and the like, and is convenient to carry and take.

The invention discloses a medicine composition used for preventing and / or treating neurodegenerative diseases. The medicine composition is prepared from, by weight, 1-10 parts of chlorogenic acid and1-10 parts of evodiamine. The experiment result shows that compatibility of the chlorogenic acid and evodiamine has a synergistic interaction effect.

The invention discloses a medicine composition for treating a digestive system disease, and a preparation method and use of the medicine composition. The medicine composition is prepared from the following ingredients in parts by weight: 5-20 parts of attractylone, and 5-20 parts of magnolol. The medicine composition disclosed by the invention is prepared from the effective parts of natural medicine raw materials in combination; the medicine composition does not need to be decocted for taking, is good in curative effect, free from toxic and side effects, not easy to produce tolerance, can be prepared into a tablet, a capsule, a pill, a granule, an oral liquid and the like, and has the advantages of portability, easy taking and the like; all the medicines are nontoxic and harmless before and after the extraction; when the medicine composition is taken at normal dosage, no toxic effect and no side effect are found; and the medicine composition is widely applicable to the patients suffering from digestive system diseases.

The invention discloses a medicinal composition for treating inflammatory bowel disease, a preparation method and application thereof. The medicinal composition comprises the following components in parts by weight: 1-10 parts of pachymaran and 1-10 parts of atractylenolide and is an combination of effective components of natural medicinal raw materials or extracts of effective components of medicinal raw materials. Experiments prove that the medicinal composition has a good treatment effect on ulcerative colitis and crohn disease. The medicinal composition can be taken without being decocted, can be prepared into tablets, capsules, pills, granules and oral solutions, is convenient to carry and take; each medicine is non-toxic and harmless before and after component compatibility, and side effects cannot be found after a normal dose is taken. The medicinal composition is clear in component, exact in curative effect and controllable in impurity, and is suitable for industrial production.

The invention provides a pharmaceutical composition containing ginkgolide B. The pharmaceutical composition comprises the ginkgolide B and pseudo-peptide thrombin inhibitor. The invention further provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages that the ginkgolide B and the pseudo-peptide thrombin inhibitor are combined to achieve a synergic effect, and the pharmaceutical composition is excellent in anticoagulation effect, low in side effect and promising in clinical application prospect; the pharmaceutical composition is novel in prescription, simple in component, clear in action mechanism, evident in curative effect, less prone to tolerance generating and capable of achieving large-scale industrial production.

The invention provides a pharmaceutical composition containing ginkgolide B. The pharmaceutical composition comprises the ginkgolide B and pseudo-peptide thrombin inhibitor. The invention further provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages that the ginkgolide B and the pseudo-peptide thrombin inhibitor are combined to achieve a synergic effect, and the pharmaceutical composition is excellent in anticoagulation effect, low in side effect and promising in clinical application prospect; the pharmaceutical composition is novel in prescription, simple in component, clear in action mechanism, evident in curative effect, less prone to tolerance generating and capable of achieving large-scale industrial production.

The invention discloses a traditional Chinese medicine composition for treating deficiency of kidney essence after radiotherapy and chemotherapy, a preparation method and application thereof. The traditional Chinese medicine composition is composed of the following raw materials and weight ratios: Rehmannia glutinosa 10-50 parts by weight, Lycium barbarum 5-30 parts by weight. Parts by weight, Ganoderma lucidum 5-30 parts by weight, Angelica sinensis 5-20 parts by weight. The present invention is composed of natural medicinal raw materials. Experiments have proved that the traditional Chinese medicine composition of the present invention has definite curative effect, no toxic and side effects, and is not easy to produce tolerance. It can be prepared into decoctions, pills, tablets, capsules, powders, and granules. , syrup, oral liquid, freeze-dried powder injection or injection, etc., have the advantages of being easy to carry and take. After the combination and dosage compatibility of the present invention, the various medicines have a relatively good effect on patients with kidney essence deficiency syndrome after tumor radiotherapy and chemotherapy. Good clinical curative effect is worthy of popularization and use.

The invention discloses dehydroandrographolide succinate eye drops. Every 100ml of the eye drops consists of the following components: 100-1000mg of dehydroandrographolide succinate, 100-500mg of sodium chloride, 10-50mg of methylparaben, 5-30mg of propylparaben, 100-500mg of EDTA-2Na and the balance of buffer solution. Meanwhile, the invention also discloses a specific preparation method of the eye drops. The eye drops have the advantages of good curative effect, zero toxic or side effect, small possibility of generating tolerance, convenience in use and universal applicability for patients suffering from infectious keratopathy. The experiment proves that due to the formula, the quality guarantee period of the eye drops in the invention can be obviously prolonged by selecting a specific dose of water-soluble medicinal auxiliary materials such as the sodium chloride, methylparaben, propylparaben, EDTA-2Na and buffer solution, and the stability of the product is improved.

The invention provides a pharmaceutical composition containing ginkgolide B. The pharmaceutical composition comprises the ginkgolide B and phosphodiesterase inhibitor. The invention further provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages that the ginkgolide B and the phosphodiesterase inhibitor are combined to achieve a synergic effect, and the pharmaceutical composition is excellent in platelet aggregation inhibiting effect, low in side effect and promising in clinical application prospect; the pharmaceutical composition is novel in prescription, simple in component, clear in action mechanism, evident in curative effect, less prone to tolerance generating and capable of achieving large-scale industrial production.

The invention provides a medicinal composition containing bilobalide B. The medicinal composition contains bilobalide B and a vitamin K antagonist. The invention further provides a preparation method and an application of the medicinal composition. The experiment proves that bilobalide B can obviously promote the anti-platelet aggregation function of warfarin, also can eliminate / reduce the natural drug resistance of a patient generated due to only use of warfarin, and enhance the affinity between the liver receptor of a patient and warfarin, and bilobalide B and warfarin have the synergistic interaction. The medicinal composition is novel in formula, simple in components, definite in action mechanism and obvious in curative effect, tolerance is difficultly generated, and industrial production can be realized.

The invention particularly relates to an antibacterial and anti-loosening coating for a titanium and titanium alloy implant material. A preparation method of the antibacterial and anti-loosening coating comprises the following steps: 1) preparing polyethyleneimine azodiol enonium salt (BPEI-NONOates) as an NO donor material by taking branched chain polyethyleneimine (BPEI) and nitric oxide (NO) as raw materials; according to the method, gelatin and NO donor substances are used for modifying a titanium metal material, the material is endowed with the continuous antibacterial effect by prolonging the release time of NO, and the problems that titanium and titanium alloy implants are prone to infection and looseness in vivo are solved.