Dehydroandrographolide succinate eye drops and preparation method and application thereof

Abstract

The invention discloses dehydroandrographolide succinate eye drops. Every 100ml of the eye drops consists of the following components: 100-1000mg of dehydroandrographolide succinate, 100-500mg of sodium chloride, 10-50mg of methylparaben, 5-30mg of propylparaben, 100-500mg of EDTA-2Na and the balance of buffer solution. Meanwhile, the invention also discloses a specific preparation method of the eye drops. The eye drops have the advantages of good curative effect, zero toxic or side effect, small possibility of generating tolerance, convenience in use and universal applicability for patients suffering from infectious keratopathy. The experiment proves that due to the formula, the quality guarantee period of the eye drops in the invention can be obviously prolonged by selecting a specific dose of water-soluble medicinal auxiliary materials such as the sodium chloride, methylparaben, propylparaben, EDTA-2Na and buffer solution, and the stability of the product is improved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an eye drop, in particular to a Yanhuning eye drop, its preparation method and application. Background technique [0002] Eye drops are one of the most commonly used drug dosage forms for ophthalmic diseases, and have direct and quick therapeutic effects on many eye diseases. Although eye drops are external preparations, their quality requirements are similar to those of injections, and they have certain requirements on pH value, osmotic pressure, sterility, visible foreign matter, viscosity, etc. Among them, the pH value has an important impact on eye drops. Improper pH value can cause irritation, increase tear secretion, lead to rapid loss of drugs, and even damage the cornea. The tolerable pH range of normal eyes is 5.0-9.0, and the osmotic pressure should be consistent with tear fluid. [0003] Yanhuning is a modified product of andrographolide, and its ch...

AI Technical Summary

Problems solved by technology

At present, the main drug of Yanhuning’s preparations on the market is mainly powder injections, and eye drops only appear in some hospital preparations. Due to the different excipients and preparation processes used, the curative effect varies greatly and the stability is poor.

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