The invention discloses a formula of a honey refined gum for treating chloasma and a preparation method thereof. The medicinal composition comprises the following crude medicaments in part by weight: 50 to 60 parts of sealwort, 30 to 40 parts of Chinese wolfberry, 10 to 20 parts of donkey-hide gelatin, 5 to 8 parts of cinnamon, 10 to 15 parts of peach blossom, 10 to 15 parts of flower of puncturevine caltrop, 10 to 15 parts of Anhui chrysanthemum flower, 10 to 15 parts of honey suckle, 10 to 15 parts of rose, 10 to 15 parts of dandelion, 10 to 15 parts of gardenia, 20 to 25 parts of mulberry, 15 to 20 parts of dahurian angelica root, 15 to 20 parts of white almond, 20 to 30 parts of white poria, 20 to 30 parts of Chinese yam rhizome, 20 to 30 parts of lily, 10 to 15 parts of dried tangerine peel, 15 to 20 parts of papaya, 15 to 20 parts of citron peel, 10 to 15 parts of folium mori, 15 to 20 parts of peach kernel, 15 to 20 parts of bunge cherry seed and 15 to 20 parts of spina date seed. The honey refined gum has the characteristics of conditioning Yin and Yang, benefiting the spleen and kidney, soothing the liver and regulating Qi, clearing heat and releasing toxin, and invigorating the circulation of blood and relaxing the bowels, can effectively regulate the female endocrine, and has good treatment effect on the chloasma, blackish facial patch, baldness, white hair, insomnia, anxiety and constipation.