A vehicle fuel hose resistant to high pressure and low in permeability is sequentially composed of a chloroprene rubber layer, a framework material layer, a chlorinated polyethylene rubber layer and a composite coating. The framework material layer is made of polyester fibers and steel wires. The composite coating is made of triisobutyl aluminum, vinyl silicone oil, polyimide, bentonite and silicon dioxide particles. The raw material of the composite coating is composed of, by weight, the triisobutyl aluminum of 5-10 parts, the vinyl silicone oil of 3-6 parts, the polyimide of 1-4 parts, the bentonite of 3-5 parts and the silicon dioxide particles of 8-15 parts. According to the hose, the framework material layer effectively improves the flexibility and the torsion resistance of the vehicle fuel hose, and the hose can be restored in shape after being subjected to high pressure; the granularity of the nano-meter silicon dioxide particles is basically uniform, so that the hose is low in permeability to liquid. Thus, the vehicle fuel hose can be widely applied to the vehicle field and has high practical value and economic value.