The application relates to the technical field of cosmetics, in particular to an anti-dandruff and anti-itch shampoo and a preparation method thereof. The anti-dandruff and anti-itch shampoo is composed of the following components in weight percentage: main surfactant 5-25%, co-surfactant 1-5%, mild surfactant 2-10%, water-soluble oil 0.1-5% %, conditioner 0.5-4%, sodium chloride 0.2-3%, citric acid 0.1-3%, sodium citrate 0.2-3%, anti-dandruff antipruritic composition 1-4%, and the balance is deionized water. The anti-dandruff and anti-itch shampoo is made of main raw materials such as main surfactant, co-surfactant, mild surfactant and the like. Through the synergistic compounding of five anti-dandruff and anti-itch ingredients, it achieves a comprehensive, long-lasting, mild anti-dandruff and anti-itch effect without hurting the scalp. The shampoo product of the present application has good cleaning and caring effects, and has the functions of long-acting anti-dandruff, oil control, anti-itching, soothing scalp, etc., and reduces the irritation of the shampoo while ensuring the anti-dandruff effect.