The invention discloses a novel analog signal amplifier which comprises a microprocessor circuit, a power supply circuit, a man-machine interface circuit, a communication interface circuit, a digital IO interface circuit, a digital and analog conversion circuit, and an analog signal differential amplification circuit. According to the novel analog signal amplifier, a signal passband is wide, and the application of a high speed control response is satisfied. Output end analog signal can be collected in a high speed, analog acquisition equipment is saved, and the hardware cost is saved. A man-machine interface is convenient, a customer operation is simple, and information can be set and obtained visually. The execution of a sensor and analog signal amplifier calibration operation is simple and quick, and a calibration result is accurate and is not affected by user professionality and the precision of other testing instruments. Communication interfaces are rich. LAN communication can be formed by multiple analog signal amplifiers through a CAN bus, the wire layout is convenient, and the reliability is high. A digital IO interface is arranged, and back level control equipment can conveniently and timely obtain the state of an acquisition quantity to control the acquisition quantity. The energy utilization efficiency is high, and heat generation is small.