96results about How to "Eliminate contamination" patented technology

An image sensor array and method of fabrication wherein the sensor includes Copper (Cu) metallization levels allowing for incorporation of a thinner interlevel dielectric stack with improved thickness uniformity to result in a pixel array exhibiting increased light sensitivity. In the sensor array, each Cu metallization level includes a Cu metal wire structure formed at locations between each array pixel and, a barrier material layer is formed on top each Cu metal wire structure that traverses the pixel optical path. By implementing a single mask or self-aligned mask methodology, a single etch is conducted to completely remove the interlevel dielectric and barrier layers that traverse the optical path. The etched opening is then refilled with dielectric material. Prior to depositing the refill dielectric, a layer of either reflective or absorptive material is formed along the sidewalls of the etched opening to improve sensitivity of the pixels by either reflecting light to the underlying photodiode or by eliminating light reflections.

An apparatus providing a fluidic cartridge including a first and second substrate and an intermediate interlayer is disclosed. The intermediate interlayer is sealedly interfaced between the first and second substrates to form therein a plurality of channels of capillary dimensions. The apparatus further includes an open reservoir, a pump chamber and a reaction chamber. The open reservoir and reaction chamber are each connected to the pump chamber through the channels. The open reservoir and reaction chamber are in fluid communication with each other via the channels. The apparatus further provides a fluid flow controlling structure, formed in the fluidic cartridge, which restricts a flow of a fluid through the reaction chamber to one direction. The apparatus further provides a linear actuator for providing a pumping action in the pump chamber to pump the fluid to recirculate from the reaction chamber to the open reservior via the channels and pump chamber.

Systems and methods for supporting a replacement heart valve are presented herein. A bioprosthesis may be stored in a storage container by suspending the bioprosthesis from a support structure. The volume of storage solution may be reduced by using a lid with a boss extending therefrom to displace some of the volume of the storage container. The support structure may rest on the base of the storage container. Additionally, there may be a holder attached to the bioprosthesis above the support structure. The holder-bioprosthesis-support structure may be constrained between the lid and base of the storage container.

A piercing station for piercing sample container caps or thick stoppers. The piercing station has a structural frame with two vertical guide rods. A carriage assembly is slidably mounted on the guide rods and is further driven to move up and down along the guide rods. The carriage assembly carries a blade holder, which in turn holds a piercing blade assembly. The blade assembly includes a center blade and two cross blades interlocked together, such that the blade assembly has a generally modified "H"-shaped cross section for piercing a cap on the sample container. Lubricant left in or on the sample container cap by the piercing station reduces the force required by the sample probe to penetrate thick stoppers for sample aspiration and level sensing. The "H"-shaped cut helps to equalize the pressure in the sample container during sampling, so that clot detection is more effective.

This is a self-contained disposable thermal cycler device in which target sequence is amplified as the samples passes over a grid of alternating temperature and then at the completion of the reaction, the amplified material is captured by probes complementary to the targeted sequence. Since the device can be sealed and is disposable, it reduces the occurrence of cross contamination or specimen carry-over.

An apparatus and method for generating ions from an aerosol and transferring the ions into a mass analyzer. In the apparatus and method, an aerosol beam is generated, the aerosol beam is directed to a spatial volume outside the mass analyzer, particles in the aerosol beam are ionized to produce the ions, and the ions are collected into the mass analyzer. As such the apparatus includes respectively an aerosol beam generator, an ion source generator, and an ion collector.

A removable secondary liquid dispensing module for use with an existing, automated liquid handling system that defines a work area having a plurality of discrete work stations. Each of the work stations of the automated liquid handling system includes a lab ware site and alignment structure enabling the removable securing standardized microtiter-plates at respective lab ware site. A plate positioning mechanism is configured to move and position the microtiter plates to and from the lab ware sites of the respective work stations thereof and into engagement with the respective carrier alignment structure thereof. Further, a primary liquid dispensing device is configured for selective contact-type dispensing of discrete quantities of fluid, in the range of about one (1) microliter to about ten (10) milliliters, into the test sites of the microtiter plates secured in the respective alignment structure of the respective work station. The removable secondary liquid dispensing module includes a base member dimensioned to fit substantially within a footprint of a work station, and mounting hardware adapted to removably secure the base member in the work station. A support platform is affixed to the base member, and is configured to support a microtiter-plate. An alignment mechanism is configured to removably receive and secure the a microtiter-plate therein by the plate positioning mechanism of the automated liquid handling system. The support platform and alignment mechanism cooperate to form and provide a lab ware site suitable for secured receipt of a microtiter-plate. The secondary liquid dispensing module further includes a secondary liquid dispensing device which is self-contained and operationally independent from the primary liquid dispensing device. The secondary dispensing device is further adapted for selective non-contact-type dispensing of discrete quantities of fluid, in the range of about one (1) nanoliter to about ten (10) microliters, into the test sites of the microtiter-plate.

The present invention provides uracil-DNA glycosylase (UDG) gene originating from Psychrobacter sp. HJ147, and amino acid sequences deduced from the gene; expression and purification of Psp HJ147 UDG gene in Escherichia coli; and characterization of UDG obtained therefrom, and the use thereof in a polymerase chain reaction (PCR). The UDG according to the present invention has a specific activity of excising uracil bases in a uracil-containing DNA substrates at a low temperature, and is easily heat-inactivated. It thus can effectively eliminate cross contamination and carry-over contamination of PCR templates often occurring after a PCR process using dUTP. Therefore, it is useful for increasing preciseness (elimination of false positives), purity and amplification efficiency of PCR.

The copper cladding normally applied to the surfaces of a submerged arc welding wire for preventing weld gun contact tip abrasive wear is replaced with a solid lubricant. This eliminates copper contamination of the weld from the copper cladding while preserving the useful life of the contact tip.